Details for: IFNW1

Gene ID: 3467

Symbol: IFNW1

Ensembl ID: ENSG00000177047

Description: interferon omega 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.55
    Marker Score: 103700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.71
    Marker Score: 30334
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6824
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3174
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.62
    Marker Score: 899
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.43
    Marker Score: 1770
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.16
    Marker Score: 677
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48010
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1526
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1742
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1549
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.79
    Marker Score: 720
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.77
    Marker Score: 444
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 545
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 212
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.6
    Marker Score: 576
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 350
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8417
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.5
    Marker Score: 286
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.37
    Marker Score: 517
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.34
    Marker Score: 547
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.29
    Marker Score: 345
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.29
    Marker Score: 1763
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 152
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.26
    Marker Score: 69
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 117
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 96
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.21
    Marker Score: 76
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 119
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 75.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 73.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.13
    Marker Score: 76
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 56
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 93
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.1
    Marker Score: 76
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 76
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 137
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 345
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 150
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.05
    Marker Score: 551
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.05
    Marker Score: 58
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.05
    Marker Score: 73
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 42.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 115
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.03
    Marker Score: 65
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 88
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 56.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.02
    Marker Score: 58
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 75
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.01
    Marker Score: 76
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 434
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.01
    Marker Score: 72
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.01
    Marker Score: 73
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 57
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 60
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 353
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 76
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.01
    Marker Score: 76
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 76
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 65
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 117
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 50
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 44

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Other Information

**Key characteristics:** * IFNW1 is a glycoprotein that is produced by a variety of cell types. * It is a member of the interferon family of proteins. * It is expressed in high levels in cells that are activated by the immune system, such as immune cells, macrophages, and dendritic cells. * It is a key regulator of the adaptive immune response by promoting the differentiation and proliferation of B cells. * It also plays a role in the regulation of cell cycle, response to virus, and humoral immune response. **Pathways and functions:** * **Adaptive immune response:** IFNW1 is a key regulator of the adaptive immune response. It is expressed in high levels in cells that are activated by the immune system, such as immune cells, macrophages, and dendritic cells. IFNW1 helps to promote the differentiation and proliferation of B cells, and it also plays a role in the regulation of the activation of T cells. * **Regulation of cell cycle:** IFNW1 is also involved in the regulation of cell cycle. It is expressed in cells that are in G1 phase of the cell cycle, and it promotes the transition of cells from G1 to S phase. * **Response to virus:** IFNW1 is a key regulator of the response to virus. It is produced by infected cells and acts on neighboring cells to promote their activation and proliferation. IFNW1 also plays a role in the regulation of the production of cytokines and chemokines, which are proteins that attract immune cells to the site of infection. * **Humoral immune response:** IFNW1 is also involved in the humoral immune response. It is expressed in cells that are infected with viruses, and it helps to regulate the production of antibodies. **Clinical significance:** IFNW1 is a promising target for the treatment of cancer and autoimmune diseases. It is a potent activator of the immune system, and it has been shown to be effective in promoting the growth and survival of cancer cells. IFNW1 is also a target for autoimmune diseases, such as rheumatoid arthritis and lupus. Treatment with IFNW1 inhibitors can slow the progression of these diseases and improve the quality of life for patients.

Genular Protein ID: 3861877011

Symbol: IFNW1_HUMAN

Name: Interferon omega-1

UniProtKB Accession Codes:

P05000 Q13168 Q5U802 Q5VWD0 Q7M4P5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2985969

Title: Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

PubMed ID: 2985969

DOI: 10.1128/mcb.5.4.768-779.1985

PubMed ID: 1647209

Title: Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein.

PubMed ID: 1647209

DOI: 10.1016/0167-4781(91)90004-6

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3895159

Title: A novel class of human type I interferons.

PubMed ID: 3895159

DOI: 10.1093/nar/13.13.4739

PubMed ID: 8142025

Title: Cloning, sequencing and expression in E. coli of interferon-omega 1 gene.

PubMed ID: 8142025

PubMed ID: 7765487

Title: Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes.

PubMed ID: 7765487

DOI: 10.1271/bbb.58.1714

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1693148

Title: Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase.

PubMed ID: 1693148

DOI: 10.1016/s0021-9258(19)38846-5

PubMed ID: 21854986

Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

PubMed ID: 21854986

DOI: 10.1016/j.cell.2011.06.048

Sequence Information:

  • Length: 195
  • Mass: 22319
  • Checksum: 1E4306F3487987FA
  • Sequence:
    • MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR 
FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE 
TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN 
MQERLRSKDR DLGSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.