Details for: IFNW1

Gene ID: 3467

Symbol: IFNW1

Ensembl ID: ENSG00000177047

Description: interferon omega 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.7088
    Cell Significance Index: 11.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3446
    Cell Significance Index: 5.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2024
    Cell Significance Index: 2.7800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1751
    Cell Significance Index: 1.8600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0564
    Cell Significance Index: 0.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0021
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0038
    Cell Significance Index: -1.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0048
    Cell Significance Index: -1.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0051
    Cell Significance Index: -0.1300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0067
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0068
    Cell Significance Index: -1.3700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0078
    Cell Significance Index: -0.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0122
    Cell Significance Index: -0.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0250
    Cell Significance Index: -1.6800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0282
    Cell Significance Index: -0.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0289
    Cell Significance Index: -0.3800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0301
    Cell Significance Index: -0.3000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0326
    Cell Significance Index: -0.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0331
    Cell Significance Index: -1.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0345
    Cell Significance Index: -1.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0384
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0390
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0408
    Cell Significance Index: -0.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0414
    Cell Significance Index: -1.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0428
    Cell Significance Index: -0.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0436
    Cell Significance Index: -1.6500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0471
    Cell Significance Index: -0.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0483
    Cell Significance Index: -1.2900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0493
    Cell Significance Index: -0.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0500
    Cell Significance Index: -0.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0506
    Cell Significance Index: -0.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0506
    Cell Significance Index: -1.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0510
    Cell Significance Index: -0.7300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0524
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0526
    Cell Significance Index: -0.6100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0541
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0562
    Cell Significance Index: -0.5700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0564
    Cell Significance Index: -0.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0590
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0594
    Cell Significance Index: -0.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0611
    Cell Significance Index: -1.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0659
    Cell Significance Index: -1.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0665
    Cell Significance Index: -1.6100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0669
    Cell Significance Index: -0.7900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0686
    Cell Significance Index: -0.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0694
    Cell Significance Index: -1.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0695
    Cell Significance Index: -0.6000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0723
    Cell Significance Index: -0.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0737
    Cell Significance Index: -1.4400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0740
    Cell Significance Index: -0.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0749
    Cell Significance Index: -1.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0750
    Cell Significance Index: -1.6200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0757
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0777
    Cell Significance Index: -1.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0817
    Cell Significance Index: -1.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0817
    Cell Significance Index: -1.9600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0820
    Cell Significance Index: -1.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0823
    Cell Significance Index: -1.6200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0823
    Cell Significance Index: -0.5300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0847
    Cell Significance Index: -1.0300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0868
    Cell Significance Index: -1.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0946
    Cell Significance Index: -1.6400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0950
    Cell Significance Index: -0.9700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0960
    Cell Significance Index: -1.2600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0993
    Cell Significance Index: -1.0000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0999
    Cell Significance Index: -1.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1019
    Cell Significance Index: -1.3300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1031
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1037
    Cell Significance Index: -1.3000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1053
    Cell Significance Index: -1.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1077
    Cell Significance Index: -1.5900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1079
    Cell Significance Index: -1.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1140
    Cell Significance Index: -1.2000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1149
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1155
    Cell Significance Index: -1.4200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1156
    Cell Significance Index: -1.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1175
    Cell Significance Index: -1.9800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1182
    Cell Significance Index: -0.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1188
    Cell Significance Index: -1.5000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1194
    Cell Significance Index: -1.7000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1194
    Cell Significance Index: -1.6100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1211
    Cell Significance Index: -1.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1217
    Cell Significance Index: -1.5600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1218
    Cell Significance Index: -1.5900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1260
    Cell Significance Index: -1.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1270
    Cell Significance Index: -1.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1275
    Cell Significance Index: -1.7400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1283
    Cell Significance Index: -1.6000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1303
    Cell Significance Index: -1.6900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1307
    Cell Significance Index: -1.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNW1 exhibits several key characteristics that enable it to function as an antiviral cytokine. These include: * **Antiviral activity:** IFNW1 is capable of inducing an antiviral state in cells, thereby inhibiting viral replication and spread. * **Type I interferon receptor binding:** IFNW1 binds to the type I interferon receptor, triggering a signaling cascade that activates various downstream pathways. * **Cytokine-mediated signaling pathway:** IFNW1 interacts with other cytokines and growth factors to modulate immune responses and cell proliferation. * **Regulation of cell cycle:** IFNW1 influences cell cycle progression, potentially inhibiting the proliferation of virus-infected cells. **Pathways and Functions:** The expression of IFNW1 is associated with various signaling pathways that regulate immune responses and cell proliferation. These include: * **Adaptive immune response:** IFNW1 plays a role in the adaptive immune response, particularly in the activation of T cells and natural killer cells. * **B cell differentiation and proliferation:** IFNW1 influences the differentiation and proliferation of B cells, contributing to the humoral immune response. * **Cytokine-mediated signaling pathway:** IFNW1 interacts with other cytokines and growth factors to modulate immune responses and cell proliferation. * **Regulation of cell cycle:** IFNW1 regulates cell cycle progression, potentially inhibiting the proliferation of virus-infected cells. **Clinical Significance:** The clinical significance of IFNW1 lies in its potential role in the treatment of viral infections and other diseases associated with immune dysfunction. As an antiviral cytokine, IFNW1 may: * **Inhibit viral replication:** IFNW1 may be used to develop novel antiviral therapies that target viral replication. * **Enhance immune response:** IFNW1 may be used to enhance the immune response in patients with compromised immune systems. * **Regulate cell proliferation:** IFNW1 may be used to regulate cell proliferation in cancer therapy. In conclusion, IFNW1 is a critical component of the immune response against viral infections, and its antiviral and immunomodulatory properties make it an attractive target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of action of IFNW1 and its potential applications in the treatment of viral infections and other diseases.

Genular Protein ID: 3861877011

Symbol: IFNW1_HUMAN

Name: Interferon omega-1

UniProtKB Accession Codes:

P05000 Q13168 Q5U802 Q5VWD0 Q7M4P5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2985969

Title: Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

PubMed ID: 2985969

DOI: 10.1128/mcb.5.4.768-779.1985

PubMed ID: 1647209

Title: Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein.

PubMed ID: 1647209

DOI: 10.1016/0167-4781(91)90004-6

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3895159

Title: A novel class of human type I interferons.

PubMed ID: 3895159

DOI: 10.1093/nar/13.13.4739

PubMed ID: 8142025

Title: Cloning, sequencing and expression in E. coli of interferon-omega 1 gene.

PubMed ID: 8142025

PubMed ID: 7765487

Title: Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes.

PubMed ID: 7765487

DOI: 10.1271/bbb.58.1714

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1693148

Title: Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase.

PubMed ID: 1693148

DOI: 10.1016/s0021-9258(19)38846-5

PubMed ID: 21854986

Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

PubMed ID: 21854986

DOI: 10.1016/j.cell.2011.06.048

Sequence Information:

  • Length: 195
  • Mass: 22319
  • Checksum: 1E4306F3487987FA
  • Sequence:
    • MALLFPLLAA LVMTSYSPVG SLGCDLPQNH GLLSRNTLVL LHQMRRISPF LCLKDRRDFR 
FPQEMVKGSQ LQKAHVMSVL HEMLQQIFSL FHTERSSAAW NMTLLDQLHT GLHQQLQHLE 
TCLLQVVGEG ESAGAISSPA LTLRRYFQGI RVYLKEKKYS DCAWEVVRME IMKSLFLSTN 
MQERLRSKDR DLGSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.