Details for: IGHEP1

Gene ID: 3498

Symbol: IGHEP1

Ensembl ID: ENSG00000253692

Description: immunoglobulin heavy constant epsilon P1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 7.9323
    Cell Significance Index: 155.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3458
    Cell Significance Index: 32.6000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6317
    Cell Significance Index: 4.7700
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.5814
    Cell Significance Index: 3.5900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4165
    Cell Significance Index: 6.0700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0344
    Cell Significance Index: 0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0175
    Cell Significance Index: -0.8200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0195
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0234
    Cell Significance Index: -0.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0286
    Cell Significance Index: -1.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0309
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0315
    Cell Significance Index: -0.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0327
    Cell Significance Index: -0.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0350
    Cell Significance Index: -0.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0389
    Cell Significance Index: -1.0400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0429
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0471
    Cell Significance Index: -1.2000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0511
    Cell Significance Index: -0.6700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0530
    Cell Significance Index: -0.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0584
    Cell Significance Index: -0.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0603
    Cell Significance Index: -0.7800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0604
    Cell Significance Index: -0.5800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0619
    Cell Significance Index: -0.6400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0623
    Cell Significance Index: -0.8000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0626
    Cell Significance Index: -0.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0648
    Cell Significance Index: -0.7300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0660
    Cell Significance Index: -0.7800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0695
    Cell Significance Index: -0.6600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0718
    Cell Significance Index: -0.8000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0721
    Cell Significance Index: -0.8300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0729
    Cell Significance Index: -1.0000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0732
    Cell Significance Index: -0.8700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0752
    Cell Significance Index: -0.8000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0772
    Cell Significance Index: -1.0100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0787
    Cell Significance Index: -0.7200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0800
    Cell Significance Index: -1.0000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0825
    Cell Significance Index: -1.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0841
    Cell Significance Index: -0.9400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0843
    Cell Significance Index: -1.1100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0871
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0871
    Cell Significance Index: -1.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0882
    Cell Significance Index: -1.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0890
    Cell Significance Index: -1.1400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0914
    Cell Significance Index: -1.1600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0915
    Cell Significance Index: -1.3900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0930
    Cell Significance Index: -1.0800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0933
    Cell Significance Index: -1.0600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0934
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0938
    Cell Significance Index: -1.0900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0939
    Cell Significance Index: -1.0400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0967
    Cell Significance Index: -1.1600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0969
    Cell Significance Index: -1.0200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0976
    Cell Significance Index: -0.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0984
    Cell Significance Index: -2.4600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0986
    Cell Significance Index: -1.0600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0986
    Cell Significance Index: -1.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1009
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1012
    Cell Significance Index: -1.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1025
    Cell Significance Index: -1.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1043
    Cell Significance Index: -1.1000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1044
    Cell Significance Index: -1.0300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1052
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1055
    Cell Significance Index: -1.0700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1075
    Cell Significance Index: -1.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1078
    Cell Significance Index: -1.2500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1079
    Cell Significance Index: -1.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1106
    Cell Significance Index: -1.0300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1123
    Cell Significance Index: -1.1600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1142
    Cell Significance Index: -1.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1157
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1164
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1165
    Cell Significance Index: -1.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1171
    Cell Significance Index: -1.1100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1195
    Cell Significance Index: -1.0100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1196
    Cell Significance Index: -1.0800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1197
    Cell Significance Index: -1.0100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1199
    Cell Significance Index: -1.2800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1231
    Cell Significance Index: -0.8200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1234
    Cell Significance Index: -1.1700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1235
    Cell Significance Index: -1.2600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1239
    Cell Significance Index: -1.1500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1243
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1246
    Cell Significance Index: -1.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1263
    Cell Significance Index: -1.3100
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1268
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1294
    Cell Significance Index: -1.2100
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.1341
    Cell Significance Index: -0.8100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1356
    Cell Significance Index: -1.1700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1357
    Cell Significance Index: -0.8800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1365
    Cell Significance Index: -1.2100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1383
    Cell Significance Index: -1.2100
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1396
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1396
    Cell Significance Index: -1.7000
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1400
    Cell Significance Index: -1.2200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1420
    Cell Significance Index: -1.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1423
    Cell Significance Index: -1.1600
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1434
    Cell Significance Index: -1.2600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1446
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHEP1 is a pseudogene, meaning it has undergone extensive mutations and deletions, rendering it non-functional in protein synthesis. However, its expression is maintained across multiple cell types, indicating the presence of alternative mechanisms of regulation or the involvement of non-coding RNA functions. Notably, IGHEP1 is primarily expressed in cells of the immune system, including those involved in antigen presentation and recognition, such as macrophages and dendritic cells. Its expression is also observed in germ cells, suggesting potential roles in reproductive development. **Pathways and Functions:** The mechanisms underlying IGHEP1 expression and function are not yet fully understood. However, several key pathways are implicated: 1. **Immune cell development and function:** IGHEP1 may play a role in regulating the development and maturation of immune cells, particularly those involved in antigen presentation, such as macrophages and dendritic cells. 2. **Antigen recognition:** IGHEP1 may influence the recognition of antigens by immune cells, potentially modulating the immune response. 3. **Germ cell development:** IGHEP1's expression in germ cells suggests a role in reproductive development and potentially in the regulation of gene expression in these cells. **Clinical Significance:** While IGHEP1 is not a functional gene, its expression in various cell types has significant implications for our understanding of immune system development and function. Future studies should aim to elucidate the mechanisms underlying IGHEP1 expression and its potential roles in disease. Some potential areas of investigation include: 1. **Immunological disorders:** IGHEP1's expression in immune cells suggests that alterations in its expression or function may contribute to immunological disorders, such as autoimmune diseases or impaired immune responses. 2. **Cancer:** IGHEP1's expression in hematopoietic progenitor cells raises the possibility that it may play a role in the development or progression of certain cancers. 3. **Reproductive health:** IGHEP1's expression in germ cells highlights the potential importance of its regulation in reproductive development and health. In conclusion, IGHEP1 is a fascinating pseudogene with significant implications for our understanding of immune system development and function. Further research is necessary to elucidate the mechanisms underlying its expression and function, as well as its potential roles in disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.