Gene IL5 - ENSG00000113525 | NCBI Gene ID: 3567

Details for: IL5

Gene ID: 3567

Symbol: IL5

Ensembl ID: ENSG00000113525

Description: interleukin 5

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Cytokine activity
(GO:0005125)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-5 receptor binding
(GO:0005137)
Interleukin-5-mediated signaling pathway
(GO:0038043)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of eosinophil differentiation
(GO:0045645)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of podosome assembly
(GO:0071803)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 5.37
Marker Score: 15654
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 4.12
Marker Score: 12224.5
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 3.1
Marker Score: 2970.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.8
Marker Score: 1472
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.01
Marker Score: 2000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.69
Marker Score: 3207
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1174
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.44
Marker Score: 601
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.31
Marker Score: 2708
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 859
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 490
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7692
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4820
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.14
Marker Score: 2319
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 506
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71833
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.99
Marker Score: 15483
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 329
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.9
Marker Score: 2578.5
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.89
Marker Score: 536
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5289
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.84
Marker Score: 837.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 465
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.66
Marker Score: 435.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.61
Marker Score: 291
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 480
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.58
Marker Score: 457
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.49
Marker Score: 320
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.48
Marker Score: 6419
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.46
Marker Score: 204
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.42
Marker Score: 322
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.38
Marker Score: 893
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.37
Marker Score: 136
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.26
Marker Score: 147
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.25
Marker Score: 80
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.24
Marker Score: 74
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.22
Marker Score: 1342
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.22
Marker Score: 57
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.2
Marker Score: 120
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.19
Marker Score: 148
Cell Name: melanocyte (CL0000148)
Fold Change: 0.18
Marker Score: 72
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.17
Marker Score: 72.5
Cell Name: astrocyte (CL0000127)
Fold Change: 0.16
Marker Score: 140
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.16
Marker Score: 72
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.15
Marker Score: 69
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.15
Marker Score: 230.5
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.14
Marker Score: 144.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.13
Marker Score: 561
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.13
Marker Score: 513
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.13
Marker Score: 46
Cell Name: glial cell (CL0000125)
Fold Change: 0.13
Marker Score: 141
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.13
Marker Score: 71
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.12
Marker Score: 147
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.11
Marker Score: 142
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.11
Marker Score: 65.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.11
Marker Score: 101
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.11
Marker Score: 718
Cell Name: podocyte (CL0000653)
Fold Change: 0.11
Marker Score: 41
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.11
Marker Score: 44
Cell Name: plasma cell (CL0000786)
Fold Change: 0.11
Marker Score: 118
Cell Name: granulocyte (CL0000094)
Fold Change: 0.1
Marker Score: 47
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.1
Marker Score: 1078
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.1
Marker Score: 139.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.1
Marker Score: 58
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.1
Marker Score: 828
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.1
Marker Score: 94
Cell Name: mast cell (CL0000097)
Fold Change: 0.09
Marker Score: 55
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.09
Marker Score: 19
Cell Name: neuron (CL0000540)
Fold Change: 0.09
Marker Score: 370
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.09
Marker Score: 44
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.09
Marker Score: 59
Cell Name: leukocyte (CL0000738)
Fold Change: 0.09
Marker Score: 51
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.09
Marker Score: 140
Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 80
Cell Name: fibroblast (CL0000057)
Fold Change: 0.08
Marker Score: 77
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.08
Marker Score: 113
Cell Name: germ cell (CL0000586)
Fold Change: 0.08
Marker Score: 134
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.08
Marker Score: 55
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.08
Marker Score: 40.5
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.07
Marker Score: 169
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.07
Marker Score: 35
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.07
Marker Score: 4321
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.07
Marker Score: 41
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.07
Marker Score: 18
Cell Name: interneuron (CL0000099)
Fold Change: 0.07
Marker Score: 31

Hover over a box to see details here...

**Key characteristics:** * IL5 is a cytokine of the interleukin-5 family. * It is produced by a variety of cell types, including B cells, T cells, and macrophages. * IL5 is a potent activator of the JAK/STAT signaling pathway. * It is involved in the regulation of B cell proliferation, differentiation, and activation. * It is also involved in the regulation of eosinophil differentiation, immunoglobulin production, and inflammation. **Pathways and functions:** * IL5 binds to the IL5 receptor on immune cells, triggering the JAK/STAT signaling pathway. * This pathway leads to the phosphorylation of STAT3, which then dimerizes with STAT5 and translocates to the nucleus. * STAT3/STAT5 signaling is involved in a variety of cellular processes, including cell growth, differentiation, and survival. * IL5 also binds to the IL5 receptor on B cells, activating them to proliferate and differentiate into plasma cells. * In addition, IL5 plays a role in the regulation of eosinophil differentiation and activation. **Clinical significance:** * IL5 is a key cytokine in the regulation of inflammation. * Dysregulation of IL5 signaling has been linked to various inflammatory diseases, including asthma, rheumatoid arthritis, and psoriasis. * Therefore, IL5 is a potential target for the treatment of these diseases. **Additional notes:** * IL5 is a pleiotropic cytokine that can have both pro-inflammatory and anti-inflammatory effects. * Its effects on immune cells are context-dependent and can vary depending on the cell type and the specific stimulus. * IL5 is a highly conserved cytokine that is expressed in many organisms.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-5

Genular Protein ID: 1928563482

Symbol: IL5_HUMAN

Name: Interleukin-5

UniProtKB Accession Codes:

P05113 Q13840

Database IDs:

Citations:

PubMed ID: 3024129

Title: Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue.

PubMed ID: 3024129

DOI: 10.1093/nar/14.22.9149

PubMed ID: 2824500

Title: Molecular cloning and structure of the human interleukin-5 gene.

PubMed ID: 2824500

DOI: 10.1016/s0021-9258(18)49295-2

PubMed ID: 3498940

Title: Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

PubMed ID: 3498940

DOI: 10.1073/pnas.84.19.6629

PubMed ID: 2823259

Title: Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

PubMed ID: 2823259

DOI: 10.1073/pnas.84.21.7388

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2653458

Title: Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF.

PubMed ID: 2653458

PubMed ID: 2361960

Title: Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells.

PubMed ID: 2361960

DOI: 10.1093/oxfordjournals.jbchem.a123041

PubMed ID: 2037074

Title: Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein.

PubMed ID: 2037074

DOI: 10.1016/0014-5793(91)80553-f

PubMed ID: 1495999

Title: Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

PubMed ID: 1495999

DOI: 10.1073/pnas.89.15.7041

PubMed ID: 7613138

Title: The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils.

PubMed ID: 7613138

DOI: 10.1159/000236985

PubMed ID: 9010276

Title: IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression.

PubMed ID: 9010276

DOI: 10.1046/j.1365-2249.1997.d01-884.x

PubMed ID: 8483502

Title: A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5.

PubMed ID: 8483502

DOI: 10.1038/363172a0

PubMed ID: 22153509

Title: Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.

PubMed ID: 22153509

DOI: 10.1016/j.str.2011.08.015

PubMed ID: 22528658

Title: Structural basis of interleukin-5 dimer recognition by its alpha receptor.

PubMed ID: 22528658

DOI: 10.1002/pro.2072

Sequence Information:

Length: 134
Mass: 15238
Checksum: DC984467179556A3
Sequence:

MRMLLHLSLL ALGAAYVYAI PTEIPTSALV KETLALLSTH RTLLIANETL RIPVPVHKNH 
QLCTEEIFQG IGTLESQTVQ GGTVERLFKN LSLIKKYIDG QKKKCGEERR RVNQFLDYLQ 
EFLGVMNTEW IIES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL5

Associated with

Cells (max top 100)

Other Information

Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue. PubMed ID: 3024129

Molecular cloning and structure of the human interleukin-5 gene. PubMed ID: 2824500

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). PubMed ID: 3498940

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5. PubMed ID: 2823259

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF. PubMed ID: 2653458

Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells. PubMed ID: 2361960

Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein. PubMed ID: 2037074

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. PubMed ID: 1495999

The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils. PubMed ID: 7613138

IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression. PubMed ID: 9010276

A novel dimer configuration revealed by the crystal structure at 2.4-A resolution of human interleukin-5. PubMed ID: 8483502

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha. PubMed ID: 22153509

Structural basis of interleukin-5 dimer recognition by its alpha receptor. PubMed ID: 22528658