Gene IL18 - ENSG00000150782 | NCBI Gene ID: 3606

Details for: IL18

Gene ID: 3606

Symbol: IL18

Ensembl ID: ENSG00000150782

Description: interleukin 18

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 processing
(R-HSA-448706)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-18 signaling
(R-HSA-9012546)
Leishmania infection
(R-HSA-9658195)
Parasitic infection pathways
(R-HSA-9824443)
Programmed cell death
(R-HSA-5357801)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Signaling by interleukins
(R-HSA-449147)
Angiogenesis
(GO:0001525)
Cell-cell signaling
(GO:0007267)
Cell population proliferation
(GO:0008283)
Cholesterol homeostasis
(GO:0042632)
Cytokine activity
(GO:0005125)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Establishment of skin barrier
(GO:0061436)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Interleukin-18 receptor binding
(GO:0045515)
Interleukin-18-mediated signaling pathway
(GO:0035655)
Natural killer cell activation
(GO:0030101)
Natural killer cell mediated cytotoxicity
(GO:0042267)
Negative regulation of myoblast differentiation
(GO:0045662)
Neutrophil activation
(GO:0042119)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of natural killer cell proliferation
(GO:0032819)
Positive regulation of neuroinflammatory response
(GO:0150078)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nk t cell proliferation
(GO:0051142)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of t-helper 1 cell cytokine production
(GO:2000556)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Positive regulation of tissue remodeling
(GO:0034105)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Regulation of cell adhesion
(GO:0030155)
Sleep
(GO:0030431)
T-helper 1 type immune response
(GO:0042088)
Triglyceride homeostasis
(GO:0070328)
Type 2 immune response
(GO:0042092)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.89
Marker Score: 4796
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.73
Marker Score: 1437
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.3
Marker Score: 1228
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.14
Marker Score: 1065.5
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.97
Marker Score: 712
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.94
Marker Score: 2141
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.93
Marker Score: 16607
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.92
Marker Score: 2022
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.78
Marker Score: 5593
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.73
Marker Score: 2550
Cell Name: basal cell (CL0000646)
Fold Change: 1.69
Marker Score: 2179
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.64
Marker Score: 1191
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.59
Marker Score: 40681.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.56
Marker Score: 494
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168256
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.44
Marker Score: 1642
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.41
Marker Score: 1694
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.38
Marker Score: 941
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.37
Marker Score: 10204
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.35
Marker Score: 3500
Cell Name: enterocyte (CL0000584)
Fold Change: 1.34
Marker Score: 6420
Cell Name: microglial cell (CL0000129)
Fold Change: 1.32
Marker Score: 2407
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.3
Marker Score: 418
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.27
Marker Score: 429
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.25
Marker Score: 9760
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.16
Marker Score: 1155
Cell Name: basophil (CL0000767)
Fold Change: 1.15
Marker Score: 544
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.14
Marker Score: 897
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.14
Marker Score: 365
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.11
Marker Score: 2257
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.1
Marker Score: 479
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.07
Marker Score: 376
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.03
Marker Score: 6229.5
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.02
Marker Score: 292
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.01
Marker Score: 35028
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1
Marker Score: 1002
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71781
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48005.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30403
Cell Name: lactocyte (CL0002325)
Fold Change: 0.98
Marker Score: 15746
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.95
Marker Score: 499
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2408
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.93
Marker Score: 2103
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.91
Marker Score: 1102
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.91
Marker Score: 1032
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2728
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5190
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.88
Marker Score: 3615
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5274
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.84
Marker Score: 858
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.84
Marker Score: 5359
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.83
Marker Score: 2948
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.82
Marker Score: 330
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.82
Marker Score: 2052
Cell Name: stem cell (CL0000034)
Fold Change: 0.82
Marker Score: 1944
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 625
Cell Name: macrophage (CL0000235)
Fold Change: 0.8
Marker Score: 895
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.8
Marker Score: 6942.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8
Marker Score: 44506.5
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.79
Marker Score: 5155
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.79
Marker Score: 228
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.77
Marker Score: 309
Cell Name: secretory cell (CL0000151)
Fold Change: 0.76
Marker Score: 1386
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.76
Marker Score: 1479
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.75
Marker Score: 1431
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.75
Marker Score: 311
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3093.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.74
Marker Score: 364
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: club cell (CL0000158)
Fold Change: 0.73
Marker Score: 854
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 662
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.72
Marker Score: 1145
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.7
Marker Score: 588
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7
Marker Score: 209
Cell Name: pneumocyte (CL0000322)
Fold Change: 0.69
Marker Score: 1114
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.67
Marker Score: 201
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.67
Marker Score: 460
Cell Name: mast cell (CL0000097)
Fold Change: 0.67
Marker Score: 387
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.66
Marker Score: 1256
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.66
Marker Score: 294
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.65
Marker Score: 10107
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.64
Marker Score: 393.5
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.64
Marker Score: 1764
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.64
Marker Score: 440
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.62
Marker Score: 1563
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.62
Marker Score: 1516
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.61
Marker Score: 585
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.61
Marker Score: 151
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.61
Marker Score: 975
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.6
Marker Score: 146
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.59
Marker Score: 916
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.59
Marker Score: 183
Cell Name: leukocyte (CL0000738)
Fold Change: 0.59
Marker Score: 338
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.59
Marker Score: 392

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**Key characteristics:** - IL-18 is a cytokine of the interleukin-1 family. - It is produced in response to various stimuli, including infection, injury, and inflammation. - IL-18 is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory effects depending on the context. - It is involved in the regulation of inflammation, immune responses, and tissue repair. **Pathways and functions:** - IL-18 signaling pathway is activated by the binding of its ligand, IL-18, to its receptor, IL-18R1. - This binding triggers a cascade of intracellular events that lead to the activation of downstream targets, including the transcription factor STAT3. - STAT3 signaling promotes the expression of inflammatory genes and the recruitment of immune cells to sites of inflammation. - IL-18 also modulates the activity of immune cells, including macrophages and dendritic cells, promoting their migration and activation. **Clinical significance:** - IL-18 plays a significant role in various human diseases, including autoimmune disorders, infections, and cancer. - Dysregulation of IL-18 signaling has been implicated in the pathogenesis of these diseases. - Inhibition of IL-18 signaling has been shown to be effective in reducing inflammation and disease activity. - Therefore, IL-18 is a potential therapeutic target for the treatment of inflammatory diseases. **Additional notes:** - IL-18 is a highly conserved cytokine with homologs in other species. - It is produced by various cell types in both healthy and pathological conditions. - IL-18 signaling is a complex and multifaceted process that involves multiple signaling pathways.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Iboctadekin

Genular Protein ID: 2166001397

Symbol: IL18_HUMAN

Name: Iboctadekin

UniProtKB Accession Codes:

Q14116 O75599 Q6FGY3 Q6WWJ7

Database IDs:

Citations:

PubMed ID: 8666798

Title: Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.

PubMed ID: 8666798

PubMed ID: 15326478

Title: A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.

PubMed ID: 15326478

DOI: 10.1038/sj.onc.1208036

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 14528293

Title: The structure and binding mode of interleukin-18.

PubMed ID: 14528293

DOI: 10.1038/nsb993

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 33883744

Title: Gasdermin D pore structure reveals preferential release of mature interleukin-1.

PubMed ID: 33883744

DOI: 10.1038/s41586-021-03478-3

PubMed ID: 25261253

Title: Structural basis for the specific recognition of IL-18 by its alpha receptor.

PubMed ID: 25261253

DOI: 10.1016/j.febslet.2014.09.019

PubMed ID: 25500532

Title: The structural basis for receptor recognition of human interleukin-18.

PubMed ID: 25500532

DOI: 10.1038/ncomms6340

Sequence Information:

Length: 193
Mass: 22326
Checksum: 323C62C203788D55
Sequence:

MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ 
GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK 
EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL 
GDRSIMFTVQ NED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL18

Associated with

Cells (max top 100)

Other Information

Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. PubMed ID: 8666798

A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing. PubMed ID: 15326478

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. PubMed ID: 10653850

Initial characterization of the human central proteome. PubMed ID: 21269460

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

The structure and binding mode of interleukin-18. PubMed ID: 14528293

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059

Gasdermin D pore structure reveals preferential release of mature interleukin-1. PubMed ID: 33883744

Structural basis for the specific recognition of IL-18 by its alpha receptor. PubMed ID: 25261253

The structural basis for receptor recognition of human interleukin-18. PubMed ID: 25500532