Details for: LALBA

Gene ID: 3906

Symbol: LALBA

Ensembl ID: ENSG00000167531

Description: lactalbumin alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 91.7249
    Cell Significance Index: 394.4400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 5.0244
    Cell Significance Index: 62.7700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.0110
    Cell Significance Index: 127.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.2390
    Cell Significance Index: 14.9600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.1561
    Cell Significance Index: 34.9200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.2852
    Cell Significance Index: 14.6000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.2388
    Cell Significance Index: 16.0300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.1984
    Cell Significance Index: 7.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1267
    Cell Significance Index: 19.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.4819
    Cell Significance Index: 4.9200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.4584
    Cell Significance Index: 4.8700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.3454
    Cell Significance Index: 2.9800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.3256
    Cell Significance Index: 4.3400
  • Cell Name: Tc1 cell (CL0000917)
    Fold Change: 0.2899
    Cell Significance Index: 0.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2578
    Cell Significance Index: 33.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1172
    Cell Significance Index: 5.5100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0884
    Cell Significance Index: 1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0342
    Cell Significance Index: 0.4900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0296
    Cell Significance Index: 0.4300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0004
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0022
    Cell Significance Index: -0.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0022
    Cell Significance Index: -1.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0084
    Cell Significance Index: -0.1400
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0108
    Cell Significance Index: -0.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0113
    Cell Significance Index: -0.7600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0126
    Cell Significance Index: -0.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0143
    Cell Significance Index: -0.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0154
    Cell Significance Index: -0.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0173
    Cell Significance Index: -0.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0177
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0179
    Cell Significance Index: -0.2200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0186
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0210
    Cell Significance Index: -0.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0224
    Cell Significance Index: -0.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0228
    Cell Significance Index: -0.2400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0238
    Cell Significance Index: -0.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0273
    Cell Significance Index: -0.6800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0303
    Cell Significance Index: -0.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0316
    Cell Significance Index: -0.4200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0321
    Cell Significance Index: -0.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0338
    Cell Significance Index: -0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0367
    Cell Significance Index: -0.5000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0371
    Cell Significance Index: -0.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0373
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0373
    Cell Significance Index: -1.0700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0397
    Cell Significance Index: -0.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0410
    Cell Significance Index: -0.8700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0412
    Cell Significance Index: -0.7000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0418
    Cell Significance Index: -0.4500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0430
    Cell Significance Index: -0.3300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0433
    Cell Significance Index: -0.4600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0439
    Cell Significance Index: -0.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0472
    Cell Significance Index: -1.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0480
    Cell Significance Index: -0.9500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0484
    Cell Significance Index: -0.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0493
    Cell Significance Index: -0.9900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0510
    Cell Significance Index: -0.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0515
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0522
    Cell Significance Index: -0.4900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0529
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0542
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0545
    Cell Significance Index: -1.0700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0547
    Cell Significance Index: -0.7200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0552
    Cell Significance Index: -1.1000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0556
    Cell Significance Index: -0.7500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0559
    Cell Significance Index: -1.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0585
    Cell Significance Index: -0.7500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0601
    Cell Significance Index: -1.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0617
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0619
    Cell Significance Index: -1.0700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0624
    Cell Significance Index: -0.7600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0654
    Cell Significance Index: -0.7500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0674
    Cell Significance Index: -0.5700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0705
    Cell Significance Index: -0.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0706
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0707
    Cell Significance Index: -0.7500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0724
    Cell Significance Index: -0.8400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0797
    Cell Significance Index: -0.9700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0797
    Cell Significance Index: -0.6200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0812
    Cell Significance Index: -0.9600
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.0842
    Cell Significance Index: -0.4200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0869
    Cell Significance Index: -1.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0882
    Cell Significance Index: -0.9900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0889
    Cell Significance Index: -1.1200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0896
    Cell Significance Index: -1.0200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0907
    Cell Significance Index: -0.9600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0908
    Cell Significance Index: -1.0500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0927
    Cell Significance Index: -1.1200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0939
    Cell Significance Index: -1.0200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0953
    Cell Significance Index: -0.4400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0955
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Alpha-lactalbumin is a 14-kDa protein composed of two identical subunits, each with a molecular weight of 7 kDa. It is a member of the 14-3-3 family of proteins, which are known for their regulatory roles in various cellular processes. Alpha-lactalbumin is highly conserved across species, suggesting its importance in maintaining cellular homeostasis. **Pathways and Functions:** Alpha-lactalbumin is involved in multiple signaling pathways, including: 1. **Lactose biosynthetic process:** Alpha-lactalbumin is a key regulator of lactose synthesis, which is essential for the production of milk in mammals. 2. **Calcium ion binding:** Alpha-lactalbumin binds to calcium ions, which is crucial for maintaining calcium homeostasis in cells. 3. **Cell-cell signaling:** Alpha-lactalbumin interacts with other proteins to regulate cell-cell communication, including the regulation of cell adhesion and migration. 4. **Apoptotic process:** Alpha-lactalbumin has been shown to regulate apoptosis (programmed cell death) in certain cell types. 5. **Defense response to bacterium:** Alpha-lactalbumin has antimicrobial properties, which help protect cells against bacterial infections. **Clinical Significance:** Dysregulation of alpha-lactalbumin expression has been implicated in various diseases, including: 1. **Gastrointestinal disorders:** Alterations in lactose synthesis due to alpha-lactalbumin dysfunction can lead to gastrointestinal disorders, such as lactose intolerance. 2. **Neurological disorders:** Abnormal expression of alpha-lactalbumin has been linked to neurological disorders, including Alzheimer's disease and multiple sclerosis. 3. **Cancer:** Alpha-lactalbumin has been shown to regulate cell growth and apoptosis in certain cancer types, suggesting its potential as a biomarker or therapeutic target. 4. **Infectious diseases:** Alpha-lactalbumin's antimicrobial properties make it a potential target for the development of novel antimicrobial therapies. In conclusion, the LALBA gene and its product, alpha-lactalbumin, play a complex and multifaceted role in human biology. Further research is needed to fully elucidate the functions and clinical significance of alpha-lactalbumin, but its importance in maintaining cellular homeostasis and regulating various biological processes is clear.

Genular Protein ID: 1888545955

Symbol: LALBA_HUMAN

Name: Alpha-lactalbumin

UniProtKB Accession Codes:

P00709 Q6FGX0 Q9UDK4

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6285305

Title: Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene.

PubMed ID: 6285305

DOI: 10.1093/nar/10.11.3503

PubMed ID: 2954544

Title: Organization and sequence of the human alpha-lactalbumin gene.

PubMed ID: 2954544

DOI: 10.1042/bj2420735

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 5049057

Title: The complete amino-acid sequence of human alpha-lactalbumin.

PubMed ID: 5049057

DOI: 10.1111/j.1432-1033.1972.tb01812.x

PubMed ID: 1401360

Title: Identification of a new molecular form of human alpha-lactalbumin.

PubMed ID: 1401360

DOI: 10.1017/s0022029900030697

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 1920433

Title: Crystal structure of human alpha-lactalbumin at 1.7-A resolution.

PubMed ID: 1920433

DOI: 10.1016/0022-2836(91)80073-4

PubMed ID: 8366079

Title: Alpha-lactalbumin possesses a distinct zinc binding site.

PubMed ID: 8366079

DOI: 10.1016/s0021-9258(19)36512-3

PubMed ID: 9537992

Title: Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin.

PubMed ID: 9537992

DOI: 10.1021/bi973000t

PubMed ID: 10080897

Title: Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method.

PubMed ID: 10080897

DOI: 10.1006/jmbi.1999.2598

PubMed ID: 15866226

Title: Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins.

PubMed ID: 15866226

DOI: 10.1016/j.jnutbio.2004.12.010

Sequence Information:

  • Length: 142
  • Mass: 16225
  • Checksum: 647F448733B06D65
  • Sequence:
    • MRFFVPLFLV GILFPAILAK QFTKCELSQL LKDIDGYGGI ALPELICTMF HTSGYDTQAI 
VENNESTEYG LFQISNKLWC KSSQVPQSRN ICDISCDKFL DDDITDDIMC AKKILDIKGI 
DYWLAHKALC TEKLEQWLCE KL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.