Details for: MAGEA12

Gene ID: 4111

Symbol: MAGEA12

Ensembl ID: ENSG00000213401

Description: MAGE family member A12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.0543
    Cell Significance Index: 0.2500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0436
    Cell Significance Index: 0.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0250
    Cell Significance Index: 0.2500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0193
    Cell Significance Index: 0.3200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0190
    Cell Significance Index: 0.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0018
    Cell Significance Index: -0.2000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0113
    Cell Significance Index: -0.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0123
    Cell Significance Index: -0.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0130
    Cell Significance Index: -0.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0144
    Cell Significance Index: -1.9800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0169
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0196
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0232
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0237
    Cell Significance Index: -0.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0265
    Cell Significance Index: -0.5400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0277
    Cell Significance Index: -0.7400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0280
    Cell Significance Index: -0.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0304
    Cell Significance Index: -1.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0304
    Cell Significance Index: -0.3900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0425
    Cell Significance Index: -0.4600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0491
    Cell Significance Index: -0.8400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0511
    Cell Significance Index: -0.3500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0528
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0543
    Cell Significance Index: -0.8800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0550
    Cell Significance Index: -0.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0550
    Cell Significance Index: -0.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0570
    Cell Significance Index: -0.5400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0578
    Cell Significance Index: -0.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0597
    Cell Significance Index: -1.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0634
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0646
    Cell Significance Index: -0.7800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0651
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0672
    Cell Significance Index: -1.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0678
    Cell Significance Index: -0.9400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0681
    Cell Significance Index: -0.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0692
    Cell Significance Index: -0.4300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0713
    Cell Significance Index: -0.9700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0720
    Cell Significance Index: -0.7100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0737
    Cell Significance Index: -0.8500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0749
    Cell Significance Index: -0.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0767
    Cell Significance Index: -0.9200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0795
    Cell Significance Index: -0.8800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0803
    Cell Significance Index: -1.1700
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0807
    Cell Significance Index: -0.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0813
    Cell Significance Index: -0.9600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0822
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0834
    Cell Significance Index: -0.7800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0835
    Cell Significance Index: -0.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0838
    Cell Significance Index: -0.8700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0841
    Cell Significance Index: -1.1800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0854
    Cell Significance Index: -0.9700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0865
    Cell Significance Index: -0.9500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0866
    Cell Significance Index: -1.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0880
    Cell Significance Index: -1.2500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0884
    Cell Significance Index: -0.9500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0884
    Cell Significance Index: -0.9200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0885
    Cell Significance Index: -0.9400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0893
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0895
    Cell Significance Index: -1.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0895
    Cell Significance Index: -0.9600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0903
    Cell Significance Index: -0.9100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0914
    Cell Significance Index: -1.0600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0918
    Cell Significance Index: -0.9600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0936
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0936
    Cell Significance Index: -0.9000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0939
    Cell Significance Index: -1.5100
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.0944
    Cell Significance Index: -0.8500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0948
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0950
    Cell Significance Index: -1.2200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0962
    Cell Significance Index: -0.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0968
    Cell Significance Index: -1.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0973
    Cell Significance Index: -1.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0982
    Cell Significance Index: -1.1600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0985
    Cell Significance Index: -1.3800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1002
    Cell Significance Index: -1.1200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1017
    Cell Significance Index: -1.0800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1034
    Cell Significance Index: -1.1900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1059
    Cell Significance Index: -1.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1068
    Cell Significance Index: -1.0900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1085
    Cell Significance Index: -1.3200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1095
    Cell Significance Index: -1.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1120
    Cell Significance Index: -1.2200
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.1127
    Cell Significance Index: -1.1600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1127
    Cell Significance Index: -1.1500
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1169
    Cell Significance Index: -1.1100
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1182
    Cell Significance Index: -0.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1186
    Cell Significance Index: -1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1198
    Cell Significance Index: -1.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1204
    Cell Significance Index: -1.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1213
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1214
    Cell Significance Index: -1.2400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1216
    Cell Significance Index: -1.6700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1226
    Cell Significance Index: -1.0800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1242
    Cell Significance Index: -1.6500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1246
    Cell Significance Index: -1.1600
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1252
    Cell Significance Index: -0.9000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1330
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAGEA12 is a non-coding gene, meaning it does not encode a protein product. Instead, it is involved in regulating gene expression through various mechanisms, including histone deacetylase binding, negative regulation of transcription by RNA polymerase II, and protein binding. These functions suggest that MAGEA12 is a key regulator of gene expression in response to cellular stress, DNA damage, and immune responses. **Pathways and Functions** MAGEA12 is involved in several biological processes, including: 1. **Histone deacetylase binding**: MAGEA12 interacts with histone deacetylases, which are enzymes that remove acetyl groups from histones, leading to chromatin compaction and gene silencing. 2. **Negative regulation of transcription by RNA polymerase II**: MAGEA12 inhibits the activity of RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Protein binding**: MAGEA12 interacts with various proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression. These functions suggest that MAGEA12 plays a crucial role in maintaining tissue homeostasis and immune regulation by regulating gene expression in response to cellular stress and immune responses. **Clinical Significance** MAGEA12 has been implicated in various diseases, including: 1. **Cancer**: MAGEA12 is overexpressed in several types of cancer, including melanoma, breast cancer, and lung cancer. This overexpression is associated with poor prognosis and reduced survival rates. 2. **Neurological disorders**: MAGEA12 is expressed in various cell types in the brain, including neurons and glial cells. Abnormal expression of MAGEA12 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. In addition, MAGEA12 has been identified as a potential therapeutic target for cancer and neurological disorders. Targeting MAGEA12 with specific therapies may provide a novel approach for treating these diseases. In conclusion, MAGEA12 is a gene of immune relevance that plays a crucial role in maintaining tissue homeostasis and immune regulation. Its widespread expression in various cell types and involvement in regulating gene expression make it a potential target for therapeutic interventions in cancer and neurological disorders. Further research is needed to fully understand the mechanisms of MAGEA12 and its clinical significance.

Genular Protein ID: 1070396150

Symbol: MAGAC_HUMAN

Name: Melanoma-associated antigen 12

UniProtKB Accession Codes:

P43365 Q6FHH8 Q9NSD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8276455

Title: Sequence and expression pattern of the human MAGE2 gene.

PubMed ID: 8276455

DOI: 10.1007/bf00188615

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

Sequence Information:

  • Length: 314
  • Mass: 34836
  • Checksum: 7E00F7CECD8F6568
  • Sequence:
    • MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS 
PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL 
LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT 
CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA 
HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS 
YPPLHEWAFR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.