Details for: MAGEA12

Gene ID: 4111

Symbol: MAGEA12

Ensembl ID: ENSG00000213401

Description: MAGE family member A12

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.98
    Marker Score: 161984
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.22
    Marker Score: 52967
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.67
    Marker Score: 8251
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.74
    Marker Score: 6817
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3170
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7692
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47958
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1537
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 545
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 206
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.38
    Marker Score: 118
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 112
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.29
    Marker Score: 134
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.28
    Marker Score: 82
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 106
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 110
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 115
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 208
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.14
    Marker Score: 111
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 420
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 118
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.12
    Marker Score: 114
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.1
    Marker Score: 82
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 123.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.09
    Marker Score: 117
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 118
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.09
    Marker Score: 167
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.09
    Marker Score: 168
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.08
    Marker Score: 171
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.08
    Marker Score: 133
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 162
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.08
    Marker Score: 110
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.07
    Marker Score: 117
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 118
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 91
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.07
    Marker Score: 115
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 109
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.06
    Marker Score: 129
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 67
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.04
    Marker Score: 260
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 103
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.04
    Marker Score: 635
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 92
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 116
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.03
    Marker Score: 118
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.03
    Marker Score: 126.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 69
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.01
    Marker Score: 128
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 84
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 199

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Other Information

**Key characteristics:** * MAGEA12 is a protein of approximately 130 kDa. * It is expressed in a variety of cell types, including immune cells, endothelial cells, and cancer cells. * It is a key regulator of the immune response, and its expression is often associated with the regulation of tumor growth and metastasis. **Pathways and functions:** * MAGEA12 is involved in a variety of cellular processes, including cell cycle regulation, apoptosis, and inflammation. * It is a key regulator of the immune response, and its expression is often associated with the regulation of tumor growth and metastasis. * It is also involved in the regulation of cell migration and invasion. **Clinical significance:** * Mutations in the MAGEA12 gene have been linked to the development of several types of cancer, including melanoma, breast cancer, and lung cancer. * Targeting MAGEA12 has been investigated as a therapeutic strategy for cancer, but it has not been successful to date. * Further research is needed to understand the role of MAGEA12 in cancer and to develop effective therapeutic strategies. **Additional information:** * MAGEA12 is a highly conserved protein, with a similar sequence in mice and humans. * It is expressed in high levels in melanoma cells and tumor cells. * It is a member of the MAGE family of cell surface molecules, which are expressed in a variety of cell types. * It is a key regulator of the immune response, and its expression is often associated with the regulation of tumor growth and metastasis.

Genular Protein ID: 1070396150

Symbol: MAGAC_HUMAN

Name: Melanoma-associated antigen 12

UniProtKB Accession Codes:

P43365 Q6FHH8 Q9NSD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 6 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SAM 1 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8276455

Title: Sequence and expression pattern of the human MAGE2 gene.

PubMed ID: 8276455

DOI: 10.1007/bf00188615

PubMed ID: 8037761

Title: Cloning and analysis of MAGE-1-related genes.

PubMed ID: 8037761

DOI: 10.1006/bbrc.1994.1963

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17942928

Title: MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.

PubMed ID: 17942928

DOI: 10.1158/0008-5472.can-07-1478

Sequence Information:

  • Length: 314
  • Mass: 34836
  • Checksum: 7E00F7CECD8F6568
  • Sequence:
    • MPLEQRSQHC KPEEGLEAQG EALGLVGAQA PATEEQETAS SSSTLVEVTL REVPAAESPS 
PPHSPQGAST LPTTINYTLW SQSDEGSSNE EQEGPSTFPD LETSFQVALS RKMAELVHFL 
LLKYRAREPF TKAEMLGSVI RNFQDFFPVI FSKASEYLQL VFGIEVVEVV RIGHLYILVT 
CLGLSYDGLL GDNQIVPKTG LLIIVLAIIA KEGDCAPEEK IWEELSVLEA SDGREDSVFA 
HPRKLLTQDL VQENYLEYRQ VPGSDPACYE FLWGPRALVE TSYVKVLHHL LKISGGPHIS 
YPPLHEWAFR EGEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.