Details for: TFDP3

Gene ID: 51270

Symbol: TFDP3

Ensembl ID: ENSG00000183434

Description: transcription factor Dp family member 3

Associated with

  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna damage response
    (GO:0006974)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription regulator complex
    (GO:0005667)
  • Transcription regulator inhibitor activity
    (GO:0140416)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.1904
    Cell Significance Index: 84.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.9152
    Cell Significance Index: 125.2300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.7106
    Cell Significance Index: 46.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2546
    Cell Significance Index: 17.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7525
    Cell Significance Index: 7.7900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.6910
    Cell Significance Index: 7.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6816
    Cell Significance Index: 8.8200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1439
    Cell Significance Index: 1.4700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1225
    Cell Significance Index: 0.9300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1198
    Cell Significance Index: 1.7400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0542
    Cell Significance Index: 0.5800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0397
    Cell Significance Index: 0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0294
    Cell Significance Index: 0.4200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0263
    Cell Significance Index: 0.2600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0186
    Cell Significance Index: 0.2000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0116
    Cell Significance Index: 0.0800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0048
    Cell Significance Index: 0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0039
    Cell Significance Index: -0.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0077
    Cell Significance Index: -0.0800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0081
    Cell Significance Index: -0.1000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0112
    Cell Significance Index: -0.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0200
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0231
    Cell Significance Index: -0.2100
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0268
    Cell Significance Index: -0.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0297
    Cell Significance Index: -0.7800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0304
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0316
    Cell Significance Index: -0.4000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0319
    Cell Significance Index: -0.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0329
    Cell Significance Index: -0.7200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0364
    Cell Significance Index: -0.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0365
    Cell Significance Index: -0.4800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0404
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0444
    Cell Significance Index: -0.8200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0455
    Cell Significance Index: -0.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0466
    Cell Significance Index: -0.7800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0467
    Cell Significance Index: -0.4200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0471
    Cell Significance Index: -0.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0489
    Cell Significance Index: -0.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0492
    Cell Significance Index: -0.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0495
    Cell Significance Index: -0.6500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0498
    Cell Significance Index: -0.6900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0499
    Cell Significance Index: -0.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0511
    Cell Significance Index: -0.8600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0513
    Cell Significance Index: -0.7500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0554
    Cell Significance Index: -0.5900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0563
    Cell Significance Index: -0.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0570
    Cell Significance Index: -0.8000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0578
    Cell Significance Index: -0.7100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0579
    Cell Significance Index: -0.5500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0600
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0616
    Cell Significance Index: -0.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0617
    Cell Significance Index: -0.7900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0654
    Cell Significance Index: -0.6900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0680
    Cell Significance Index: -0.4400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0692
    Cell Significance Index: -0.7900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0695
    Cell Significance Index: -0.7700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0696
    Cell Significance Index: -0.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0696
    Cell Significance Index: -0.8300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0700
    Cell Significance Index: -0.7600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0705
    Cell Significance Index: -0.8600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0705
    Cell Significance Index: -0.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0714
    Cell Significance Index: -0.6700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0721
    Cell Significance Index: -0.8300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0753
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0757
    Cell Significance Index: -0.8800
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0768
    Cell Significance Index: -0.8200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0775
    Cell Significance Index: -0.7900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0784
    Cell Significance Index: -0.7300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0791
    Cell Significance Index: -0.7800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0792
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0808
    Cell Significance Index: -0.7600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0827
    Cell Significance Index: -0.7600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0828
    Cell Significance Index: -0.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0832
    Cell Significance Index: -0.8300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0845
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0887
    Cell Significance Index: -0.8300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0897
    Cell Significance Index: -0.7900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0921
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0931
    Cell Significance Index: -0.7700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0936
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TFDP3 is a transcription factor that belongs to the Dp family, characterized by its ability to bind to specific DNA sequences and regulate gene expression. The protein is highly conserved across species, suggesting a conserved role in cellular processes. TFDP3 is primarily expressed in cells involved in hematopoiesis, including megakaryocytes, hematopoietic stem cells, and progenitor cells. The gene is also expressed in other cell types, such as intestinal epithelial cells and stromal cells, indicating a broader role in tissue homeostasis. **Pathways and Functions:** TFDP3 is involved in several key pathways, including: 1. **Chromatin and DNA-binding transcription factor activity**: TFDP3 regulates chromatin structure and transcription factor activity, influencing gene expression in various cell types. 2. **DNA damage response**: TFDP3 modulates the response to DNA damage, ensuring the integrity of the genome and preventing mutations. 3. **Negative regulation of G1/S transition of the mitotic cell cycle**: TFDP3 inhibits cell cycle progression, allowing for proper cell division and preventing uncontrolled proliferation. 4. **Regulation of transcription by RNA polymerase II**: TFDP3 regulates the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** TFDP3 is of significant interest in the context of hematopoietic disorders, as its dysregulation has been implicated in various diseases, including: 1. **Hematopoietic malignancies**: TFDP3 expression is often altered in hematopoietic cancers, suggesting a role in tumorigenesis. 2. **Hematopoietic stem cell transplantation**: TFDP3 may play a critical role in the maintenance of hematopoietic stem cells and their ability to repopulate the bone marrow. 3. **Immune disorders**: TFDP3 expression has been observed in immune cells, suggesting a potential role in the regulation of immune responses. In conclusion, TFDP3 is a transcription factor that plays a critical role in regulating various cellular processes, including cell cycle progression, DNA damage response, and transcriptional regulation. Its dysregulation has been implicated in hematopoietic disorders, highlighting the importance of this gene in understanding the pathogenesis of these diseases. Further research is needed to fully elucidate the role of TFDP3 in human health and disease.

Genular Protein ID: 342140738

Symbol: TFDP3_HUMAN

Name: Transcription factor Dp family member 3

UniProtKB Accession Codes:

Q5H9I0 Q6DK49 Q9NZ54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12097419

Title: Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.

PubMed ID: 12097419

DOI: 10.4049/jimmunol.169.2.1102

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 16418725

Title: A functionally distinct member of the DP family of E2F subunits.

PubMed ID: 16418725

DOI: 10.1038/sj.onc.1209343

PubMed ID: 17062573

Title: Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F.

PubMed ID: 17062573

DOI: 10.1074/jbc.m606169200

PubMed ID: 20559320

Title: E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

PubMed ID: 20559320

DOI: 10.1038/cdd.2010.70

Sequence Information:

  • Length: 405
  • Mass: 44967
  • Checksum: AE6F5709FE7E4C03
  • Sequence:
    • MAKYVSLTEA NEELKVLMDE NQTSRPVAVH TSTVNPLGKQ LLPKTFGQSS VNIDQQVVIG 
MPQRPAASNI PVVGSPNPPS THFASQNQHS YSSPPWAGQH NRKGEKNGMG LCRLSMKVWE 
TVQRKGTTSC QEVVGELVAK FRAASNHASP NESAYDVKNI KRRTYDALNV LMAMNIISRE 
KKKIKWIGLT TNSAQNCQNL RVERQKRLER IKQKQSELQQ LILQQIAFKN LVLRNQYVEE 
QVSQRPLPNS VIHVPFIIIS SSKKTVINCS ISDDKSEYLF KFNSSFEIHD DTEVLMWMGM 
TFGLESGSCS AEDLKMARNL VPKALEPYVT EMAQGTFGGV FTTAGSRSNG TWLSASDLTN 
IAIGMLATSS GGSQYSGSRV ETPAVEEEEE EDNNDDDLSE NDEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.