Details for: KRT76

Gene ID: 51350

Symbol: KRT76

Ensembl ID: ENSG00000185069

Description: keratin 76

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.9178
    Cell Significance Index: 47.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1932
    Cell Significance Index: 2.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1585
    Cell Significance Index: 2.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0590
    Cell Significance Index: 0.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0542
    Cell Significance Index: 0.8000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0017
    Cell Significance Index: 0.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0032
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0046
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0057
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0067
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0153
    Cell Significance Index: -0.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0156
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0175
    Cell Significance Index: -0.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0197
    Cell Significance Index: -0.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0204
    Cell Significance Index: -0.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0239
    Cell Significance Index: -1.3400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0253
    Cell Significance Index: -0.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0277
    Cell Significance Index: -0.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0282
    Cell Significance Index: -0.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0291
    Cell Significance Index: -1.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0321
    Cell Significance Index: -0.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0356
    Cell Significance Index: -0.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0360
    Cell Significance Index: -0.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0396
    Cell Significance Index: -0.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0398
    Cell Significance Index: -0.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0429
    Cell Significance Index: -0.9300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0438
    Cell Significance Index: -0.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0451
    Cell Significance Index: -1.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0463
    Cell Significance Index: -0.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0474
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0484
    Cell Significance Index: -0.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0498
    Cell Significance Index: -0.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0524
    Cell Significance Index: -1.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0538
    Cell Significance Index: -0.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0549
    Cell Significance Index: -1.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0559
    Cell Significance Index: -1.0300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0569
    Cell Significance Index: -0.6000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0610
    Cell Significance Index: -0.8300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0625
    Cell Significance Index: -0.8300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0630
    Cell Significance Index: -0.8400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0643
    Cell Significance Index: -0.7700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0646
    Cell Significance Index: -0.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0646
    Cell Significance Index: -0.8500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0661
    Cell Significance Index: -0.6700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0664
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0665
    Cell Significance Index: -1.3000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0674
    Cell Significance Index: -0.8800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0676
    Cell Significance Index: -0.7700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0677
    Cell Significance Index: -0.8100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0689
    Cell Significance Index: -0.9000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0690
    Cell Significance Index: -0.9200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0694
    Cell Significance Index: -0.8200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0703
    Cell Significance Index: -0.9000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0706
    Cell Significance Index: -0.8300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0708
    Cell Significance Index: -0.8100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0717
    Cell Significance Index: -0.8600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0719
    Cell Significance Index: -0.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0721
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0723
    Cell Significance Index: -0.4800
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0746
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0748
    Cell Significance Index: -0.9100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0750
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0752
    Cell Significance Index: -0.9100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0762
    Cell Significance Index: -0.7700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0765
    Cell Significance Index: -0.8800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0768
    Cell Significance Index: -0.9700
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.0769
    Cell Significance Index: -0.8400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0775
    Cell Significance Index: -0.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0781
    Cell Significance Index: -1.1100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0793
    Cell Significance Index: -0.8500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0802
    Cell Significance Index: -0.9200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0806
    Cell Significance Index: -0.9000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0808
    Cell Significance Index: -0.8800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0813
    Cell Significance Index: -0.9100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0813
    Cell Significance Index: -0.9000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0815
    Cell Significance Index: -0.8800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0816
    Cell Significance Index: -0.9200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0822
    Cell Significance Index: -0.9100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0824
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0829
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0832
    Cell Significance Index: -0.9300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0833
    Cell Significance Index: -0.9100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0834
    Cell Significance Index: -1.0700
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0844
    Cell Significance Index: -0.9100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0847
    Cell Significance Index: -0.8700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0851
    Cell Significance Index: -0.8400
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0860
    Cell Significance Index: -0.9100
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0861
    Cell Significance Index: -0.9200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0863
    Cell Significance Index: -0.9400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0867
    Cell Significance Index: -0.9300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0870
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT76 is highly expressed in epithelial cells, including keratinocytes, intestinal epithelial cells, corneal epithelial cells, and squamous epithelial cells. 2. **Protein Structure:** KRT76 is a type II keratin, composed of two alpha-helical chains, which form a coiled-coil structure. 3. **Function:** KRT76 contributes to the formation of the cornified envelope, a critical component of the skin barrier, and is involved in maintaining the structural integrity of epithelial cells. **Pathways and Functions:** 1. **Keratinization:** KRT76 plays a crucial role in the process of keratinization, which is essential for the development and maintenance of the skin barrier. 2. **Cytoskeleton Organization:** KRT76 interacts with other intermediate filament proteins to form a network that provides mechanical support and stability to cells. 3. **Extracellular Exosome:** KRT76 is secreted by epithelial cells and contributes to the formation of extracellular exosomes, which play a role in intercellular communication. 4. **Developmental Biology:** KRT76 is involved in the development of various tissues and organs, including the skin, intestine, and nervous system. **Clinical Significance:** Dysregulation or mutations in KRT76 have been implicated in several diseases, including: 1. **Epidermolysis Bullosa Simplex:** A genetic disorder characterized by blistering skin lesions, which is caused by mutations in the KRT5 and KRT14 genes, which are closely linked to KRT76. 2. **Dermatological Disorders:** Abnormalities in KRT76 expression have been linked to various dermatological disorders, such as ichthyosis and psoriasis. 3. **Cancer:** Altered expression of KRT76 has been observed in certain types of cancer, including breast and colon cancer. In conclusion, KRT76 is a vital component of the keratin family, playing a crucial role in maintaining the structural integrity and function of epithelial cells. Its dysregulation or mutations have significant implications for various diseases, highlighting the importance of further research into the functions and mechanisms of KRT76.

Genular Protein ID: 1089356305

Symbol: K22O_HUMAN

Name: Keratin, type II cytoskeletal 2 oral

UniProtKB Accession Codes:

Q01546 B4DRR3 Q7Z795

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1282112

Title: Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different.

PubMed ID: 1282112

DOI: 10.1111/j.1432-0436.1992.tb00690.x

PubMed ID: 15737194

Title: Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

PubMed ID: 15737194

DOI: 10.1111/j.0022-202x.2004.23530.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 638
  • Mass: 65841
  • Checksum: 6A312B8260BE06A9
  • Sequence:
    • MNRQVCKKSF SGRSQGFSGR SAVVSGSSRM SCVARSGGAG GGACGFRSGA GSFGSRSLYN 
LGSNKSISIS VAAGSSRAGG FGGGRSSCGF AGGYGGGFGG SYGGGFGGGR GVGSGFGGAG 
GFGGAGGFGG PGVFGGPGSF GGPGGFGPGG FPGGIQEVIV NQSLLQPLNV EIDPQIGQVK 
AQEREQIKTL NNKFASFIDK VRFLEQQNKV LETKWELLQQ QTTGSGPSSL EPCFESYISF 
LCKQLDSLLG ERGNLEGELK SMQDLVEDFK KKYEDEINKR TAAENEFVGL KKDVDAAFMN 
KVELQAKVDS LTDEVSFLRT LYEMELSQMQ SHASDTSVVL SMDNNRCLDL GSIIAEVRAQ 
YEEIAQRSKS EAEALYQTKL GELQTTAGRH GDDLRNTKSE IMELNRMIQR LRAEIENVKK 
QNANLQTAIA EAEQRGEMAL KDANAKLQDL QTALQKAKDD LARLLRDYQE LMNVKLALDV 
EIATYRKLLE GEECRMSGEC QSAVCISVVS NVTSTSGSSG SSRGVFGGVS GSGSGGYKGG 
SSSSSSSGYG VSGGSGSGYG GVSSGSTGGR GSSGSYQSSS SGSRLGGAGS ISVSHSGMGS 
SSGSIQTSGG SGYKSGGGGS TSIRFSQTTS SSQHSSTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.