Details for: POLR2J3

Gene ID: 548644

Symbol: POLR2J3

Ensembl ID: ENSG00000285437

Description: RNA polymerase II subunit J3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 10.26
    Marker Score: 7943
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.45
    Marker Score: 2896
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 6.21
    Marker Score: 9576
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 4.63
    Marker Score: 11537
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.99
    Marker Score: 2454
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.87
    Marker Score: 5692
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.07
    Marker Score: 7237
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.97
    Marker Score: 1971.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.61
    Marker Score: 2057
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 2.59
    Marker Score: 3189
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.46
    Marker Score: 6936
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.41
    Marker Score: 5887
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.28
    Marker Score: 2249
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.25
    Marker Score: 47917
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.24
    Marker Score: 3451
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 2.05
    Marker Score: 11675
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.97
    Marker Score: 39272
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.97
    Marker Score: 1188
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.95
    Marker Score: 689
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.93
    Marker Score: 73387
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.93
    Marker Score: 71216
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.91
    Marker Score: 2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.9
    Marker Score: 14540
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17822
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.87
    Marker Score: 7732
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27753
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.85
    Marker Score: 2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.85
    Marker Score: 113503
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 6998
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.76
    Marker Score: 16733
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14738
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.71
    Marker Score: 1797
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.7
    Marker Score: 1021
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.66
    Marker Score: 1556
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.62
    Marker Score: 985
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2365
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.59
    Marker Score: 457
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.58
    Marker Score: 1649
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.58
    Marker Score: 1145
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.55
    Marker Score: 3795.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.54
    Marker Score: 1053.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.53
    Marker Score: 1586
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.53
    Marker Score: 745
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.5
    Marker Score: 2311
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5
    Marker Score: 1087
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.47
    Marker Score: 632
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.45
    Marker Score: 327
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.45
    Marker Score: 419
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.45
    Marker Score: 825
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.44
    Marker Score: 3014
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.41
    Marker Score: 527
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.38
    Marker Score: 410
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.38
    Marker Score: 821
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.36
    Marker Score: 701
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.36
    Marker Score: 1282
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.32
    Marker Score: 3706
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.3
    Marker Score: 980
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.29
    Marker Score: 1216
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.29
    Marker Score: 434
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.27
    Marker Score: 770.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.25
    Marker Score: 318
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.23
    Marker Score: 5090
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.22
    Marker Score: 10539
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.22
    Marker Score: 1025
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.22
    Marker Score: 473
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.21
    Marker Score: 16017
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.19
    Marker Score: 479
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.17
    Marker Score: 3333
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.16
    Marker Score: 602.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.16
    Marker Score: 1036
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.15
    Marker Score: 265
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.14
    Marker Score: 1142
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.12
    Marker Score: 497
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.12
    Marker Score: 284
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.09
    Marker Score: 393
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 1.08
    Marker Score: 373
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.07
    Marker Score: 1137
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.06
    Marker Score: 1131
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.06
    Marker Score: 5194
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.06
    Marker Score: 5067
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.04
    Marker Score: 1774.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.04
    Marker Score: 493
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.03
    Marker Score: 433
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.03
    Marker Score: 701
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1283
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.02
    Marker Score: 1812
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.02
    Marker Score: 353
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.02
    Marker Score: 721
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.02
    Marker Score: 5341.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.01
    Marker Score: 222
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.01
    Marker Score: 421
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.99
    Marker Score: 261.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.98
    Marker Score: 583
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.98
    Marker Score: 236
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.97
    Marker Score: 445
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.96
    Marker Score: 733
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.96
    Marker Score: 2278
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.95
    Marker Score: 408
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.93
    Marker Score: 587
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.93
    Marker Score: 1026

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Other Information

**Key Characteristics:** POLR2J3 is a subunit of the RNAPII complex, which is responsible for transcribing protein-coding genes in eukaryotic cells. The RNAPII complex is composed of five subunits, including POLR2J3, POLR2A, POLR2B, POLR2C, and POLR2D. POLR2J3 is the smallest subunit of the complex and is highly conserved across species, suggesting its essential role in transcriptional regulation. **Pathways and Functions:** POLR2J3 is involved in several key pathways, including: 1. **DNA Binding:** POLR2J3 interacts with other RNAPII subunits to form a complex that binds to DNA, positioning the transcription machinery for efficient transcription. 2. **Protein Binding:** POLR2J3 interacts with various proteins, including transcription factors and co-activators, to regulate transcriptional activity. 3. **Protein Dimerization Activity:** POLR2J3 participates in the formation of protein dimers, which are essential for the assembly of the RNAPII complex. 4. **RNA Polymerase II Activity:** POLR2J3 is directly involved in the catalytic activity of the RNAPII complex, facilitating the transcription of protein-coding genes. **Clinical Significance:** The clinical significance of POLR2J3 is still being explored, but its expression in various immune cells suggests that this gene may play a role in regulating immune responses. Dysregulation of POLR2J3 has been implicated in several diseases, including cancer and autoimmune disorders. For example: 1. **Cancer:** Alterations in POLR2J3 expression have been observed in various types of cancer, suggesting its potential role in tumorigenesis. 2. **Autoimmune Disorders:** POLR2J3 has been implicated in the regulation of immune cell function, and dysregulation of this gene may contribute to autoimmune diseases. 3. **Infectious Diseases:** POLR2J3 may play a role in the regulation of immune responses to infectious diseases, such as viral infections. In conclusion, POLR2J3 is a critical component of the RNAPII complex, and its expression in immune cells highlights its potential role in regulating immune responses. Further research is needed to fully elucidate the functions and clinical significance of this gene, but the available data suggest that POLR2J3 is a key player in transcriptional control and immune cell regulation.

Genular Protein ID: 2990567070

Symbol: A0A0B4J2F8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J2F8

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 4 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 2 Proteomes 2 RefSeq 3 SUPFAM 1 VEuPathDB 2

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

Sequence Information:

  • Length: 115
  • Mass: 13074
  • Checksum: F0345B65C524AD18
  • Sequence:
    • MNAPPAFESF LLFEGEKITI NKDTKVPNAC LFTINKEDHT LGNIIKSQLL KDPQVLFAGY 
KVPHPLEHKI IIRVQTTPDY SPQEAFTNAI TDLISELSLL EERFRTCLLP LRLLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.