Details for: CACHD1
Gene ID: 57685
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CACHD1
Ensembl ID: ENSG00000158966
Description: cache domain containing 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 18.41rCSI 41.27%PRS 69.95
-
CSI 18.07rCSI 24.73%PRS 76.63
-
CSI 16.03rCSI 34.15%PRS 61.09
-
CSI 12.22rCSI 24.79%PRS 65.31
-
CSI 12.16rCSI 31.25%PRS 81.31
-
CSI 11.2rCSI 9.85%PRS 75.26
-
CSI 10.64rCSI 17.43%PRS 75.98
-
CSI 10.33rCSI 10.7%PRS 88.08
-
CSI 8.87rCSI 27.71%PRS 70.55
-
CSI 8.81rCSI 26.15%PRS 92.04
-
CSI 7.7rCSI 7.17%PRS 86.08
-
CSI 7.69rCSI 31.01%PRS 85.43
-
CSI 7.24rCSI 12.7%PRS 79.97
-
CSI 7.14rCSI 8.88%PRS 85.6
-
CSI 6.93rCSI 14.38%PRS 82.39
-
CSI 6.92rCSI 14.22%PRS 72.47
-
CSI 6.86rCSI 12.34%PRS 79.21
-
CSI 6.43rCSI 16.26%PRS 88.79
-
CSI 5.52rCSI 8.72%PRS 86.16
-
CSI 5.4rCSI 4.48%PRS 86.18
-
CSI 5.38rCSI 6.22%PRS 77.56
-
CSI 5.23rCSI 9.79%PRS 74.86
-
CSI 5.14rCSI 14.15%PRS 81.12
-
CSI 5.09rCSI 14.33%PRS 80.36
-
CSI 4.92rCSI 13.15%PRS 78.04
-
CSI 4.73rCSI 16.2%PRS 71.42
-
CSI 4.68rCSI 6.03%PRS 70.23
-
CSI 4.49rCSI 21.5%PRS 85.21
-
CSI 4.42rCSI 10.09%PRS 77.35
-
CSI 4.38rCSI 6.98%PRS 76.97
-
CSI 4.23rCSI 8.39%PRS 81.17
-
CSI 4.21rCSI 5.85%PRS 83.42
-
CSI 4.18rCSI 3.31%PRS 75.72
-
CSI 4.14rCSI 8.98%PRS 73.21
-
CSI 4.08rCSI 5.24%PRS 75.83
-
CSI 3.91rCSI 19.28%PRS 90.84
-
CSI 3.87rCSI 11.22%PRS 75.39
-
CSI 3.66rCSI 8.68%PRS 84.04
-
CSI 3.62rCSI 15.37%PRS 77.9
-
CSI 3.56rCSI 2.63%PRS 79.72
-
CSI 3.42rCSI 17.49%PRS 87.33
-
CSI 3.39rCSI 4.35%PRS 81.42
-
CSI 3.35rCSI 7.73%PRS 74.28
-
CSI 3.3rCSI 12.37%PRS 78.68
-
CSI 3.21rCSI 12.12%PRS 69.37
-
CSI 3.2rCSI 5.19%PRS 80.02
-
CSI 3.06rCSI 3.66%PRS 69.16
-
CSI 3.06rCSI 17.99%PRS 69.51
-
CSI 3.04rCSI 6.93%PRS 78.54
-
CSI 3.04rCSI 4.64%PRS 84.93
-
CSI 2.91rCSI 3.12%PRS 87.06
-
CSI 2.91rCSI 13.67%PRS 75.89
-
CSI 2.9rCSI 10.45%PRS 67
-
CSI 2.88rCSI 7.04%PRS 77.86
-
CSI 2.85rCSI 5.03%PRS 68.55
-
CSI 2.78rCSI 5.59%PRS 76.98
-
CSI 2.76rCSI 7.28%PRS 90.25
-
CSI 2.74rCSI 4.74%PRS 77.82
-
CSI 2.73rCSI 8.88%PRS 82.21
-
CSI 2.67rCSI 3.9%PRS 89.31
-
CSI 2.62rCSI 4.16%PRS 78.96
-
CSI 2.52rCSI 17.12%PRS 77.15
-
CSI 2.5rCSI 4.19%PRS 69.02
-
CSI 2.41rCSI 2.32%PRS 79.87
-
CSI 2.4rCSI 2.62%PRS 86.71
-
CSI 2.38rCSI 1.84%PRS 88.37
-
CSI 2.34rCSI 5.7%PRS 66.86
-
CSI 2.29rCSI 12.68%PRS 91.83
-
CSI 2.28rCSI 5.63%PRS 85.58
-
CSI 2.25rCSI 53.96%PRS 66.88
-
CSI 2.23rCSI 53.78%PRS 67.32
-
CSI 2.2rCSI 5.57%PRS 76.94
-
CSI 2.04rCSI 3.26%PRS 88.28
-
CSI 2.01rCSI 2.69%PRS 82.84
-
CSI 1.95rCSI 3.54%PRS 77.23
-
CSI 1.91rCSI 2.96%PRS 87.66
-
CSI 1.81rCSI 2.33%PRS 87.73
-
CSI 1.73rCSI 24.55%PRS 76.64
-
CSI 1.7rCSI 4.43%PRS 84.76
-
CSI 1.62rCSI 1.87%PRS 78.48
-
CSI 1.6rCSI 7.04%PRS 73.8
-
CSI 1.58rCSI 3.49%PRS 72.29
-
CSI 1.54rCSI 1.53%PRS 79.45
-
CSI 1.51rCSI 3.63%PRS 86.98
-
CSI 1.49rCSI 3.87%PRS 89.67
-
CSI 1.38rCSI 8.15%PRS 76.3
-
CSI 1.32rCSI 9.96%PRS 74.71
-
CSI 1.31rCSI 6.9%PRS 75.45
-
CSI 1.31rCSI 2.11%PRS 70.42
-
CSI 1.3rCSI 7.35%PRS 72.37
-
CSI 1.25rCSI 4.78%PRS 76.97
-
CSI 1.25rCSI 4.19%PRS 69.88
-
CSI 1.25rCSI 6.81%PRS 81.42
-
CSI 1.1rCSI 9.26%PRS 72.46
-
CSI 1rCSI 2.74%PRS 89.92
-
CSI 0.98rCSI 3.85%PRS 64.98
-
CSI 0.92rCSI 5.88%PRS 79.95
-
CSI 0.9rCSI 14.13%PRS 86.07
-
CSI 0.88rCSI 2.11%PRS 72.87
-
CSI 0.84rCSI 5.38%PRS 88
-
CSI 0.2rCSI 1.7%PRS 88.7%
-
CSI 0.3rCSI 2.1%PRS 74.6%
-
CSI 0.4rCSI 8.3%PRS 75.3%
-
CSI 0.6rCSI 5.9%PRS 81.2%
-
CSI 0.6rCSI 7.0%PRS 73.4%
-
CSI 0.7rCSI 5.3%PRS 80.4%
-
CSI 0.7rCSI 4.9%PRS 74.0%
-
CSI 0.8rCSI 15.9%PRS 76.2%
-
CSI 0.8rCSI 5.9%PRS 90.7%
-
CSI 0.8rCSI 5.8%PRS 75.7%
-
CSI 0.8rCSI 5.4%PRS 88.0%
-
CSI 0.9rCSI 2.1%PRS 72.9%
-
CSI 0.9rCSI 14.1%PRS 86.1%
-
CSI 0.9rCSI 5.9%PRS 80.0%
-
CSI 1.0rCSI 3.9%PRS 65.0%
-
CSI 1.0rCSI 2.7%PRS 89.9%
-
CSI 1.1rCSI 9.3%PRS 72.5%
-
CSI 1.3rCSI 6.8%PRS 81.4%
-
CSI 1.3rCSI 4.2%PRS 69.9%
-
CSI 1.3rCSI 4.8%PRS 77.0%
-
CSI 1.3rCSI 7.4%PRS 72.4%
-
CSI 1.3rCSI 2.1%PRS 70.4%
-
CSI 1.3rCSI 6.9%PRS 75.5%
-
CSI 1.3rCSI 10.0%PRS 74.7%
-
CSI 1.4rCSI 8.2%PRS 76.3%
-
CSI 1.5rCSI 3.9%PRS 89.7%
-
CSI 1.5rCSI 3.6%PRS 87.0%
-
CSI 1.5rCSI 1.5%PRS 79.5%
-
CSI 1.6rCSI 3.5%PRS 72.3%
-
CSI 1.6rCSI 7.0%PRS 73.8%
-
CSI 1.6rCSI 1.9%PRS 78.5%
-
CSI 1.7rCSI 4.4%PRS 84.8%
-
CSI 1.7rCSI 24.6%PRS 76.6%
-
CSI 1.8rCSI 2.3%PRS 87.7%
-
CSI 1.9rCSI 3.0%PRS 87.7%
-
CSI 2.0rCSI 3.5%PRS 77.2%
-
CSI 2.0rCSI 2.7%PRS 82.8%
-
CSI 2.0rCSI 3.3%PRS 88.3%
-
CSI 2.2rCSI 5.6%PRS 76.9%
-
CSI 2.2rCSI 53.8%PRS 67.3%
-
CSI 2.3rCSI 54.0%PRS 66.9%
-
CSI 2.3rCSI 5.6%PRS 85.6%
-
CSI 2.3rCSI 12.7%PRS 91.8%
-
CSI 2.3rCSI 5.7%PRS 66.9%
-
CSI 2.4rCSI 1.8%PRS 88.4%
-
CSI 2.4rCSI 2.6%PRS 86.7%
-
CSI 2.4rCSI 2.3%PRS 79.9%
-
CSI 2.5rCSI 4.2%PRS 69.0%
-
CSI 2.5rCSI 17.1%PRS 77.2%
-
CSI 2.6rCSI 4.2%PRS 79.0%
-
CSI 2.7rCSI 3.9%PRS 89.3%
-
CSI 2.7rCSI 8.9%PRS 82.2%
-
CSI 2.7rCSI 4.7%PRS 77.8%
-
CSI 2.8rCSI 7.3%PRS 90.3%
-
CSI 2.8rCSI 5.6%PRS 77.0%
-
CSI 2.9rCSI 5.0%PRS 68.6%
-
CSI 2.9rCSI 7.0%PRS 77.9%
-
CSI 2.9rCSI 10.5%PRS 67.0%
-
CSI 2.9rCSI 13.7%PRS 75.9%
-
CSI 2.9rCSI 3.1%PRS 87.1%
-
CSI 3.0rCSI 4.6%PRS 84.9%
-
CSI 3.0rCSI 6.9%PRS 78.5%
-
CSI 3.1rCSI 18.0%PRS 69.5%
-
CSI 3.1rCSI 3.7%PRS 69.2%
-
CSI 3.2rCSI 5.2%PRS 80.0%
-
CSI 3.2rCSI 12.1%PRS 69.4%
-
CSI 3.3rCSI 12.4%PRS 78.7%
-
CSI 3.4rCSI 7.7%PRS 74.3%
-
CSI 3.4rCSI 4.4%PRS 81.4%
-
CSI 3.4rCSI 17.5%PRS 87.3%
-
CSI 3.6rCSI 2.6%PRS 79.7%
-
CSI 3.6rCSI 15.4%PRS 77.9%
-
CSI 3.7rCSI 8.7%PRS 84.0%
-
CSI 3.9rCSI 11.2%PRS 75.4%
-
CSI 3.9rCSI 19.3%PRS 90.8%
-
CSI 4.1rCSI 5.2%PRS 75.8%
-
CSI 4.1rCSI 9.0%PRS 73.2%
-
CSI 4.2rCSI 3.3%PRS 75.7%
-
CSI 4.2rCSI 5.9%PRS 83.4%
-
CSI 4.2rCSI 8.4%PRS 81.2%
-
CSI 4.4rCSI 7.0%PRS 77.0%
-
CSI 4.4rCSI 10.1%PRS 77.4%
-
CSI 4.5rCSI 21.5%PRS 85.2%
-
CSI 4.7rCSI 6.0%PRS 70.2%
-
CSI 4.7rCSI 16.2%PRS 71.4%
-
CSI 4.9rCSI 13.2%PRS 78.0%
-
CSI 5.1rCSI 14.3%PRS 80.4%
-
CSI 5.1rCSI 14.2%PRS 81.1%
-
CSI 5.2rCSI 9.8%PRS 74.9%
-
CSI 5.4rCSI 6.2%PRS 77.6%
-
CSI 5.4rCSI 4.5%PRS 86.2%
-
CSI 5.5rCSI 8.7%PRS 86.2%
-
CSI 6.4rCSI 16.3%PRS 88.8%
-
CSI 6.9rCSI 12.3%PRS 79.2%
-
CSI 6.9rCSI 14.2%PRS 72.5%
-
CSI 6.9rCSI 14.4%PRS 82.4%
-
CSI 7.1rCSI 8.9%PRS 85.6%
-
CSI 7.2rCSI 12.7%PRS 80.0%
-
CSI 7.7rCSI 31.0%PRS 85.4%
-
CSI 7.7rCSI 7.2%PRS 86.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2674515232
Symbol: CAHD1_HUMAN
Name: VWFA and cache domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10997877
Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10997877
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 1274
- Mass: 142290
- Checksum: C20F8657C456A755
- Sequence:
MARQPEEEET AVARARRPPL WLLCLVACWL LGAGAEADFS ILDEAQVLAS QMRRLAAEEL GVVTMQRIFN SFVYTEKISN GESEVQQLAK KIREKFNRYL DVVNRNKQVV EASYTAHLTS PLTAIQDCCT IPPSMMEFDG NFNTNVSRTI SCDRLSTTVN SRAFNPGRDL NSVLADNLKS NPGIKWQYFS SEEGIFTVFP AHKFRCKGSY EHRSRPIYVS TVRPQSKHIV VILDHGASVT DTQLQIAKDA AQVILSAIDE HDKISVLTVA DTVRTCSLDQ CYKTFLSPAT SETKRKMSTF VSSVKSSDSP TQHAVGFQKA FQLIRSTNNN TKFQANTDMV IIYLSAGITS KDSSEEDKKA TLQVINEENS FLNNSVMILT YALMNDGVTG LKELAFLRDL AEQNSGKYGV PDRMALPVIK GSMMVLNQLS NLETTVGRFY TNLPNRMIDE AVFSLPFSDE MGDGLIMTVS KPCYFGNLLL GIVGVDVNLA YILEDVTYYQ DSLASYTFLI DDKGYTLMHP SLTRPYLLSE PPLHTDIIHY ENIPKFELVR QNILSLPLGS QIIAVPVNSS LSWHINKLRE TGKEAYNVSY AWKMVQDTSF ILCIVVIQPE IPVKQLKNLN TVPSSKLLYH RLDLLGQPSA CLHFKQLATL ESPTIMLSAG SFSSPYEHLS QPETKRMVEH YTAYLSDNTR LIANPGLKFS VRNEVMATSH VTDEWMTQME MSSLNTYIVR RYIATPNGVL RIYPGSLMDK AFDPTRRQWY LHAVANPGLI SLTGPYLDVG GAGYVVTISH TIHSSSTQLS SGHTVAVMGI DFTLRYFYKV LMDLLPVCNQ DGGNKIRCFI MEDRGYLVAH PTLIDPKGHA PVEQQHITHK EPLVANDILN HPNFVKKNLC NSFSDRTVQR FYKFNTSLAG DLTNLVHGSH CSKYRLARIP GTNAFVGIVN ETCDSLAFCA CSMVDRLCLN CHRMEQNECE CPCECPLEVN ECTGNLTNAE NRNPSCEVHQ EPVTYTAIDP GLQDALHQCV NSRCSQRLES GDCFGVLDCE WCMVDSDGKT HLDKPYCAPQ KECFGGIVGA KSPYVDDMGA IGDEVITLNM IKSAPVGPVA GGIMGCIMVL VLAVYAYRHQ IHRRSHQHMS PLAAQEMSVR MSNLENDRDE RDDDSHEDRG IISNTRFIAA VIERHAHSPE RRRRYWGRSG TESDHGYSTM SPQEDSENPP CNNDPLSAGV DVGNHDEDLD LDTPPQTAAL LSHKFHHYRS HHPTLHHSHH LQAAVTVHTV DAEC
Genular Protein ID: 3223143063
Symbol: A0A0A0MQY7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
Sequence Information:
- Length: 1223
- Mass: 136711
- Checksum: 37D82E5CB4A453BF
- Sequence:
MRRLAAEELG VVTMQRIFNS FVYTEKISNG ESEVQQLAKK IREKFNRYLD VVNRNKQVVE ASYTAHLTSP LTAIQDCCTI PPSMMEFDGN FNTNVSRTIS CDRLSTTVNS RAFNPGRDLN SVLADNLKSN PGIKWQYFSS EEGIFTVFPA HKFRCKGSYE HRSRPIYVST VRPQSKHIVV ILDHGASVTD TQLQIAKDAA QVILSAIDEH DKISVLTVAD TVRTCSLDQC YKTFLSPATS ETKRKMSTFV SSVKSSDSPT QHAVGFQKAF QLIRSTNNNT KFQANTDMVI IYLSAGITSK DSSEEDKKAT LQVINEENSF LNNSVMILTY ALMNDGVTGL KELAFLRDLA EQNSGKYGVP DRMALPVIKG SMMVLNQLSN LETTVGRFYT NLPNRMIDEA VFSLPFSDEM GDGLIMTVSK PCYFGNLLLG IVGVDVNLAY ILEDVTYYQD SLASYTFLID DKGYTLMHPS LTRPYLLSEP PLHTDIIHYE NIPKFELVRQ NILSLPLGSQ IIAVPVNSSL SWHINKLRET GKEAYNVSYA WKMVQDTSFI LCIVVIQPEI PVKQLKNLNT VPSSKLLYHR LDLLGQPSAC LHFKQLATLE SPTIMLSAGS FSSPYEHLSQ PETKRMVEHY TAYLSDNTRL IANPGLKFSV RNEVMATSHV TDEWMTQMEM SSLNTYIVRR YIATPNGVLR IYPGSLMDKA FDPTRRQWYL HAVANPGLIS LTGPYLDVGG AGYVVTISHT IHSSSTQLSS GHTVAVMGID FTLRYFYKVL MDLLPVCNQD GGNKIRCFIM EDRGYLVAHP TLIDPKGHAP VEQQHITHKE PLVANDILNH PNFVKKNLCN SFSDRTVQRF YKFNTSLAGD LTNLVHGSHC SKYRLARIPG TNAFVGIVNE TCDSLAFCAC SMVDRLCLNC HRMEQNECEC PCECPLEVNE CTGNLTNAEN RNPSCEVHQE PVTYTAIDPG LQDALHQCVN SRCSQRLESG DCFGVLDCEW CMVDSDGKTH LDKPYCAPQK ECFGGIVGAK SPYVDDMGAI GDEVITLNMI KSAPVGPVAG GIMGCIMVLV LAVYAYRHQI HRRSHQHMSP LAAQEMSVRM SNLENDRDER DDDSHEDRGI ISNTRFIAAV IERHAHSPER RRRYWGRSGT ESDHGYSTMS PQEDSENPPC NNDPLSAGVD VGNHDEDLDL DTPPQTAALL SHKFHHYRSH HPTLHHSHHL QAAVTVHTVD AEC