Details for: RMRP

Gene ID: 6023

Symbol: RMRP

Ensembl ID: ENSG00000277027

Description: RNA component of mitochondrial RNA processing endoribonuclease

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2627
    Cell Significance Index: 3.4400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.2099
    Cell Significance Index: 3.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2045
    Cell Significance Index: 3.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1297
    Cell Significance Index: 1.9400
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0523
    Cell Significance Index: 0.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0301
    Cell Significance Index: 3.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0084
    Cell Significance Index: 1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0041
    Cell Significance Index: 3.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0013
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0081
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0094
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0180
    Cell Significance Index: -0.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0189
    Cell Significance Index: -0.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0204
    Cell Significance Index: -0.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0303
    Cell Significance Index: -2.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0325
    Cell Significance Index: -0.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0408
    Cell Significance Index: -0.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0515
    Cell Significance Index: -0.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0603
    Cell Significance Index: -1.2800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0710
    Cell Significance Index: -0.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0906
    Cell Significance Index: -1.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0907
    Cell Significance Index: -1.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0910
    Cell Significance Index: -1.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0960
    Cell Significance Index: -2.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0983
    Cell Significance Index: -1.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0994
    Cell Significance Index: -1.6800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1133
    Cell Significance Index: -2.2800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1136
    Cell Significance Index: -1.3000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1169
    Cell Significance Index: -2.3000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1298
    Cell Significance Index: -1.6300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1302
    Cell Significance Index: -1.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1455
    Cell Significance Index: -3.4900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1494
    Cell Significance Index: -1.9500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1522
    Cell Significance Index: -1.7900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1552
    Cell Significance Index: -1.2300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1560
    Cell Significance Index: -1.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1673
    Cell Significance Index: -2.4700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1738
    Cell Significance Index: -2.5700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1819
    Cell Significance Index: -2.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1839
    Cell Significance Index: -2.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1896
    Cell Significance Index: -11.6200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1920
    Cell Significance Index: -2.5600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1979
    Cell Significance Index: -2.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1997
    Cell Significance Index: -2.6300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1999
    Cell Significance Index: -2.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2029
    Cell Significance Index: -2.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2071
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2080
    Cell Significance Index: -2.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2140
    Cell Significance Index: -3.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2148
    Cell Significance Index: -2.3400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.2171
    Cell Significance Index: -2.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2175
    Cell Significance Index: -2.5700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2236
    Cell Significance Index: -2.6400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2303
    Cell Significance Index: -3.2200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2314
    Cell Significance Index: -1.8000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2375
    Cell Significance Index: -2.6300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2398
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2429
    Cell Significance Index: -2.2800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2435
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2439
    Cell Significance Index: -2.2600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2495
    Cell Significance Index: -2.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2508
    Cell Significance Index: -2.5600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2527
    Cell Significance Index: -2.4500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2668
    Cell Significance Index: -2.6400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2670
    Cell Significance Index: -3.2500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2868
    Cell Significance Index: -2.6300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2874
    Cell Significance Index: -3.0000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3014
    Cell Significance Index: -4.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3023
    Cell Significance Index: -3.9200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3027
    Cell Significance Index: -3.6300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3048
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3075
    Cell Significance Index: -3.7800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3081
    Cell Significance Index: -3.5000
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.3133
    Cell Significance Index: -2.3000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3148
    Cell Significance Index: -3.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3340
    Cell Significance Index: -4.2200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3348
    Cell Significance Index: -3.8900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3406
    Cell Significance Index: -4.8400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.3434
    Cell Significance Index: -3.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3549
    Cell Significance Index: -3.6700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3571
    Cell Significance Index: -4.2500
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.3576
    Cell Significance Index: -2.4800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3587
    Cell Significance Index: -3.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3634
    Cell Significance Index: -4.2900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3689
    Cell Significance Index: -4.0500
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: -0.3722
    Cell Significance Index: -2.6100
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.3773
    Cell Significance Index: -4.2800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3882
    Cell Significance Index: -4.8500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3965
    Cell Significance Index: -4.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4147
    Cell Significance Index: -4.9000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4264
    Cell Significance Index: -5.4000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4270
    Cell Significance Index: -4.7700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4290
    Cell Significance Index: -3.7800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4326
    Cell Significance Index: -4.7900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4393
    Cell Significance Index: -4.8800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.4402
    Cell Significance Index: -2.5400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.4452
    Cell Significance Index: -4.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4456
    Cell Significance Index: -11.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RMRP is a small RNA molecule, approximately 172 nucleotides in length, that is predominantly expressed in the mitochondria of various cell types. It is encoded by a single gene, ENSG00000277027, which is significantly upregulated in cells with high energy demands, such as neurons and endothelial cells. RMRP's unique structure, consisting of a long 5' untranslated region and a short 3' untranslated region, allows it to interact with various mitochondrial RNAs and regulate their processing. **Pathways and Functions:** RMRP's primary function is to regulate the processing and maturation of mitochondrial RNAs, particularly the removal of non-coding regions and the 5' trimming of mitochondrial RNAs. This process is crucial for maintaining the integrity of mitochondrial transcripts and ensuring the proper expression of mitochondrial genes. RMRP's activity is mediated by its interaction with mitochondrial RNA-binding proteins, which facilitate the recognition and removal of non-coding regions. In addition to its role in mitochondrial RNA processing, RMRP has been implicated in various cellular processes, including: 1. **Regulation of mitochondrial biogenesis**: RMRP has been shown to regulate the expression of mitochondrial genes involved in biogenesis, such as the mitochondrial genome and mitochondrial ribosomal RNA. 2. **Mitochondrial DNA repair**: RMRP has been implicated in the repair of mitochondrial DNA damage, which is essential for maintaining mitochondrial function and preventing disease. 3. **Cellular stress response**: RMRP has been shown to regulate the expression of genes involved in the cellular stress response, including heat shock proteins and antioxidant enzymes. **Clinical Significance:** Dysregulation of RMRP has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: RMRP's role in regulating mitochondrial function and biogenesis has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Mitochondrial disorders**: RMRP's dysfunction has been implicated in mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome. 3. **Cancer**: RMRP's role in regulating mitochondrial function and biogenesis has been linked to cancer, particularly in the context of mitochondrial dysfunction and metabolic reprogramming. In conclusion, RMRP is a critical regulator of mitochondrial RNA processing and a key player in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of RMRP and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.