Details for: SNORD15A

Gene ID: 6079

Symbol: SNORD15A

Ensembl ID: ENSG00000206941

Description: small nucleolar RNA, C/D box 15A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.1602
    Cell Significance Index: 12.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.0964
    Cell Significance Index: 11.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1774
    Cell Significance Index: 5.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1158
    Cell Significance Index: 5.2500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0297
    Cell Significance Index: 0.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0194
    Cell Significance Index: 0.4200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0170
    Cell Significance Index: 0.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0085
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0356
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0420
    Cell Significance Index: -0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0453
    Cell Significance Index: -2.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0513
    Cell Significance Index: -2.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0526
    Cell Significance Index: -1.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0566
    Cell Significance Index: -1.9900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0818
    Cell Significance Index: -1.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0854
    Cell Significance Index: -1.1000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0892
    Cell Significance Index: -1.0700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0895
    Cell Significance Index: -0.9700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0907
    Cell Significance Index: -1.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0991
    Cell Significance Index: -2.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0999
    Cell Significance Index: -2.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1018
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1205
    Cell Significance Index: -2.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1255
    Cell Significance Index: -1.6100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1288
    Cell Significance Index: -1.3700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1385
    Cell Significance Index: -1.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1399
    Cell Significance Index: -1.7200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1431
    Cell Significance Index: -1.5100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1448
    Cell Significance Index: -1.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1515
    Cell Significance Index: -1.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1563
    Cell Significance Index: -1.8600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1567
    Cell Significance Index: -1.8200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1686
    Cell Significance Index: -2.2200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1753
    Cell Significance Index: -2.1900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1807
    Cell Significance Index: -1.9200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1808
    Cell Significance Index: -2.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1811
    Cell Significance Index: -1.7000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1835
    Cell Significance Index: -1.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1897
    Cell Significance Index: -1.9800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1908
    Cell Significance Index: -2.1500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1914
    Cell Significance Index: -1.9800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1915
    Cell Significance Index: -1.6200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1948
    Cell Significance Index: -1.9600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1962
    Cell Significance Index: -1.9700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2010
    Cell Significance Index: -1.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2109
    Cell Significance Index: -2.1400
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2151
    Cell Significance Index: -1.8800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2163
    Cell Significance Index: -2.7300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2204
    Cell Significance Index: -2.7600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2204
    Cell Significance Index: -2.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2275
    Cell Significance Index: -2.8400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2279
    Cell Significance Index: -2.8600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2280
    Cell Significance Index: -2.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2290
    Cell Significance Index: -2.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2312
    Cell Significance Index: -2.7300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2318
    Cell Significance Index: -2.8100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2319
    Cell Significance Index: -2.6200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2326
    Cell Significance Index: -2.3500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2333
    Cell Significance Index: -2.6500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2381
    Cell Significance Index: -2.7400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2384
    Cell Significance Index: -2.5100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2395
    Cell Significance Index: -2.5100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2407
    Cell Significance Index: -2.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2412
    Cell Significance Index: -2.7600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.2416
    Cell Significance Index: -2.7600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2441
    Cell Significance Index: -2.6800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2482
    Cell Significance Index: -2.5600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2497
    Cell Significance Index: -2.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2500
    Cell Significance Index: -2.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2533
    Cell Significance Index: -2.7600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2565
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2576
    Cell Significance Index: -2.4100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2599
    Cell Significance Index: -2.4200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.2608
    Cell Significance Index: -2.7700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2629
    Cell Significance Index: -4.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2643
    Cell Significance Index: -2.5400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2667
    Cell Significance Index: -2.7600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2688
    Cell Significance Index: -2.6200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2694
    Cell Significance Index: -2.4300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2742
    Cell Significance Index: -2.6000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2950
    Cell Significance Index: -2.4400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.2963
    Cell Significance Index: -2.7600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3059
    Cell Significance Index: -2.6400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3133
    Cell Significance Index: -2.7600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3429
    Cell Significance Index: -2.8300
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.3432
    Cell Significance Index: -2.5700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3665
    Cell Significance Index: -2.8200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.5701
    Cell Significance Index: -2.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD15A is a member of the C/D box snoRNA family, which is involved in the modification of ribosomal RNA (rRNA) and other RNAs. This snoRNA is specifically expressed in cells of the immune system, including pericytes, cardiac endothelial cells, cardiac muscle myoblasts, immature innate lymphoid cells, lymphoid lineage-restricted progenitor cells, fibroblasts of cardiac tissue, smooth muscle myoblasts, neuronal receptor cells, B cells, and memory B cells. The expression of SNORD15A in these cell types suggests its potential involvement in the regulation of immune responses and cellular homeostasis. **Pathways and Functions:** SNORD15A is involved in the RNA processing pathway, specifically in the modification of rRNA and other RNAs. This snoRNA has been shown to interact with the nucleolus, a region within the nucleus responsible for the synthesis of ribosomal RNA. The nucleolus is a critical site for the assembly of ribosomes, which are essential for protein synthesis. SNORD15A has been implicated in the regulation of immune responses by modulating the expression of genes involved in inflammation and immune cell development. Additionally, SNORD15A may play a role in maintaining cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. **Clinical Significance:** The clinical significance of SNORD15A lies in its potential role in immune-related disorders, such as autoimmune diseases, cancer, and immunodeficiency disorders. Alterations in SNORD15A expression have been linked to various diseases, including rheumatoid arthritis, multiple sclerosis, and lymphoma. Furthermore, SNORD15A has been shown to be involved in the regulation of immune cell development and function, making it a potential target for the treatment of immune-related disorders. Additionally, SNORD15A may play a role in the development of cardiovascular diseases, given its expression in cardiac endothelial cells and fibroblasts of cardiac tissue. In conclusion, SNORD15A is a small nucleolar RNA that plays a critical role in RNA processing and immune regulation. Its expression in various cell types, including immune cells, suggests its potential involvement in the regulation of immune responses and cellular homeostasis. Further research is needed to fully elucidate the role of SNORD15A in human disease, but its potential as a therapeutic target for immune-related disorders is an exciting area of investigation. **Recommendations:** 1. Further studies are needed to elucidate the specific mechanisms by which SNORD15A regulates immune responses and cellular homeostasis. 2. The role of SNORD15A in the development of immune-related disorders, such as autoimmune diseases and cancer, should be further investigated. 3. SNORD15A may be a potential therapeutic target for the treatment of immune-related disorders, and further research is needed to explore its potential as a therapeutic agent. **Limitations:** This review highlights the potential role of SNORD15A in immune regulation and cellular homeostasis, but further research is needed to fully elucidate its mechanisms of action and clinical significance. The limitations of this review include the need for further studies to confirm the expression and function of SNORD15A in human disease, as well as the need for further investigation into its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.