Details for: TRAV6

Gene ID: 6956

Symbol: TRAV6

Ensembl ID: ENSG00000211780

Description: T cell receptor alpha variable 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.2851
    Cell Significance Index: 10.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6198
    Cell Significance Index: 9.5900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3964
    Cell Significance Index: 3.9800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0045
    Cell Significance Index: 0.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0261
    Cell Significance Index: -3.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0336
    Cell Significance Index: -4.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0373
    Cell Significance Index: -7.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0795
    Cell Significance Index: -1.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0983
    Cell Significance Index: -2.5100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1028
    Cell Significance Index: -1.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1044
    Cell Significance Index: -2.5300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1090
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1224
    Cell Significance Index: -3.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1236
    Cell Significance Index: -3.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1284
    Cell Significance Index: -3.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1290
    Cell Significance Index: -1.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1355
    Cell Significance Index: -3.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1484
    Cell Significance Index: -2.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1568
    Cell Significance Index: -7.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1770
    Cell Significance Index: -4.0900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1834
    Cell Significance Index: -2.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1876
    Cell Significance Index: -4.7800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1942
    Cell Significance Index: -1.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1942
    Cell Significance Index: -2.3000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1958
    Cell Significance Index: -2.1200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2098
    Cell Significance Index: -2.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2161
    Cell Significance Index: -3.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2210
    Cell Significance Index: -4.3200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2226
    Cell Significance Index: -2.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2247
    Cell Significance Index: -10.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2302
    Cell Significance Index: -2.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2316
    Cell Significance Index: -4.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2369
    Cell Significance Index: -4.0500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2384
    Cell Significance Index: -2.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2438
    Cell Significance Index: -4.0800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2623
    Cell Significance Index: -3.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2628
    Cell Significance Index: -5.1300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2662
    Cell Significance Index: -2.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2663
    Cell Significance Index: -3.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2678
    Cell Significance Index: -1.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2686
    Cell Significance Index: -3.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2748
    Cell Significance Index: -3.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2759
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2778
    Cell Significance Index: -3.0900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2787
    Cell Significance Index: -3.3900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2828
    Cell Significance Index: -2.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2844
    Cell Significance Index: -3.4300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2846
    Cell Significance Index: -3.4600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2882
    Cell Significance Index: -3.6000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2882
    Cell Significance Index: -2.0100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2894
    Cell Significance Index: -3.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2902
    Cell Significance Index: -4.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2906
    Cell Significance Index: -4.0300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2949
    Cell Significance Index: -3.8700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2965
    Cell Significance Index: -3.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3007
    Cell Significance Index: -2.8900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.3012
    Cell Significance Index: -2.7100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3034
    Cell Significance Index: -3.3900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3046
    Cell Significance Index: -2.8600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3052
    Cell Significance Index: -3.3900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3070
    Cell Significance Index: -4.0400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3093
    Cell Significance Index: -4.1100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3099
    Cell Significance Index: -3.5200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3108
    Cell Significance Index: -3.4000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3111
    Cell Significance Index: -3.6600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3129
    Cell Significance Index: -3.6300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3133
    Cell Significance Index: -3.9700
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.3143
    Cell Significance Index: -3.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3151
    Cell Significance Index: -4.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3185
    Cell Significance Index: -3.9500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3221
    Cell Significance Index: -3.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3250
    Cell Significance Index: -3.8400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3263
    Cell Significance Index: -3.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3277
    Cell Significance Index: -3.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3283
    Cell Significance Index: -3.7000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3285
    Cell Significance Index: -3.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3289
    Cell Significance Index: -3.7900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3296
    Cell Significance Index: -3.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3299
    Cell Significance Index: -5.0100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3304
    Cell Significance Index: -3.5100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3305
    Cell Significance Index: -3.9900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3327
    Cell Significance Index: -4.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3341
    Cell Significance Index: -3.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3343
    Cell Significance Index: -4.7500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.3372
    Cell Significance Index: -3.6500
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.3377
    Cell Significance Index: -3.3000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3380
    Cell Significance Index: -3.3000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3383
    Cell Significance Index: -5.4400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3389
    Cell Significance Index: -4.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3394
    Cell Significance Index: -3.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3396
    Cell Significance Index: -3.2200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3417
    Cell Significance Index: -3.5900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3456
    Cell Significance Index: -4.5100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3469
    Cell Significance Index: -4.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3494
    Cell Significance Index: -3.0200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.3497
    Cell Significance Index: -2.4100
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.3509
    Cell Significance Index: -3.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV6 exhibits several distinct characteristics that make it an essential player in the adaptive immune response. These include: 1. **Variable region**: TRAV6 encodes a variable region of the T cell receptor alpha chain, which is responsible for recognizing and binding to specific antigens. 2. **Adaptive immune response**: TRAV6 is involved in the adaptive immune response, which is a highly specific and targeted response to pathogens. 3. **Cell type specificity**: TRAV6 is expressed in various cell types, including endothelial cells, mast cells, and hematopoietic cells, indicating its diverse role in different tissues and immune responses. 4. **Pathogen recognition**: TRAV6 recognizes and responds to pathogens, including bacteria, suggesting its importance in the response to bacterial infections. **Pathways and Functions:** TRAV6 is integrated into several key pathways and functions, including: 1. **Adaptive immune response pathway**: TRAV6 plays a crucial role in the adaptive immune response, which involves the activation of T cells and the production of antibodies. 2. **T cell receptor complex**: TRAV6 is part of the T cell receptor complex, which is responsible for recognizing and binding to specific antigens. 3. **Antigen presentation**: TRAV6 is involved in antigen presentation, which is the process by which antigens are presented to T cells for recognition and response. 4. **Immune cell activation**: TRAV6 is involved in the activation of immune cells, including T cells and dendritic cells, which are essential for the adaptive immune response. **Clinical Significance:** TRAV6 has significant clinical implications, particularly in the context of immune-related disorders. These include: 1. **Autoimmune diseases**: TRAV6 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the adaptive immune response is dysregulated. 2. **Cancer immunotherapy**: TRAV6 has been explored as a target for cancer immunotherapy, where the adaptive immune response is harnessed to recognize and target cancer cells. 3. **Infectious disease**: TRAV6 has been implicated in the response to bacterial infections, where the adaptive immune response is crucial for clearance of pathogens. 4. **Immunodeficiency disorders**: TRAV6 has been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where the adaptive immune response is severely impaired. In conclusion, TRAV6 is a critical component of the adaptive immune response, playing a pivotal role in recognizing and responding to pathogens. Its diverse expression in various cell types and its involvement in key pathways and functions highlight its importance in different tissues and immune responses. Further research is needed to fully elucidate the role of TRAV6 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.