Details for: TMSB4XP4

Gene ID: 7118

Symbol: TMSB4XP4

Ensembl ID: ENSG00000223551

Description: TMSB4X pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 49.7151
    Cell Significance Index: -20.4800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 22.8188
    Cell Significance Index: 393.3700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 15.4959
    Cell Significance Index: 143.4100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.4125
    Cell Significance Index: 16.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6355
    Cell Significance Index: 8.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0336
    Cell Significance Index: -1.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1290
    Cell Significance Index: -72.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1665
    Cell Significance Index: -19.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2033
    Cell Significance Index: -34.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2713
    Cell Significance Index: -17.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5040
    Cell Significance Index: -18.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5283
    Cell Significance Index: -15.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6072
    Cell Significance Index: -13.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6371
    Cell Significance Index: -39.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6423
    Cell Significance Index: -29.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6716
    Cell Significance Index: -18.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7116
    Cell Significance Index: -19.3700
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.8065
    Cell Significance Index: -3.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8330
    Cell Significance Index: -11.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8529
    Cell Significance Index: -21.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0147
    Cell Significance Index: -14.4500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -1.0464
    Cell Significance Index: -9.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.1406
    Cell Significance Index: -40.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.1475
    Cell Significance Index: -19.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.1646
    Cell Significance Index: -19.7800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -1.1750
    Cell Significance Index: -12.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.2015
    Cell Significance Index: -13.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -1.2077
    Cell Significance Index: -15.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.2239
    Cell Significance Index: -16.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.2349
    Cell Significance Index: -20.0000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.2567
    Cell Significance Index: -15.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.2949
    Cell Significance Index: -37.3100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.3054
    Cell Significance Index: -13.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3147
    Cell Significance Index: -59.5900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.3287
    Cell Significance Index: -21.0800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.3449
    Cell Significance Index: -22.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3629
    Cell Significance Index: -34.0400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.3720
    Cell Significance Index: -15.5000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -1.3949
    Cell Significance Index: -13.2600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -1.3991
    Cell Significance Index: -19.6500
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.4068
    Cell Significance Index: -16.6100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.4122
    Cell Significance Index: -20.6600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.4148
    Cell Significance Index: -14.8300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.4210
    Cell Significance Index: -18.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.4245
    Cell Significance Index: -21.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.4302
    Cell Significance Index: -17.5800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.4531
    Cell Significance Index: -16.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.4550
    Cell Significance Index: -18.3600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -1.4707
    Cell Significance Index: -17.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -1.4709
    Cell Significance Index: -20.2000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.4834
    Cell Significance Index: -17.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.4960
    Cell Significance Index: -15.1800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -1.4988
    Cell Significance Index: -14.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.5070
    Cell Significance Index: -19.3600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.5111
    Cell Significance Index: -18.9800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -1.5374
    Cell Significance Index: -20.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.5414
    Cell Significance Index: -16.2600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -1.5425
    Cell Significance Index: -17.9300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.5439
    Cell Significance Index: -17.6700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -1.5487
    Cell Significance Index: -14.4200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -1.5488
    Cell Significance Index: -15.5300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.5545
    Cell Significance Index: -20.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.5585
    Cell Significance Index: -20.7100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -1.5681
    Cell Significance Index: -12.9700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -1.5726
    Cell Significance Index: -20.1400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -1.5774
    Cell Significance Index: -20.7000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -1.5967
    Cell Significance Index: -16.1300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -1.5980
    Cell Significance Index: -18.3300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -1.5998
    Cell Significance Index: -18.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.6002
    Cell Significance Index: -19.9900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -1.6113
    Cell Significance Index: -18.7200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -1.6118
    Cell Significance Index: -18.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.6122
    Cell Significance Index: -16.4600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.6160
    Cell Significance Index: -19.2300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -1.6206
    Cell Significance Index: -17.7900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -1.6209
    Cell Significance Index: -20.3000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -1.6337
    Cell Significance Index: -20.5000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.6401
    Cell Significance Index: -18.9900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -1.6437
    Cell Significance Index: -19.9800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -1.6449
    Cell Significance Index: -18.6800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -1.6465
    Cell Significance Index: -19.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.6465
    Cell Significance Index: -17.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.6518
    Cell Significance Index: -17.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.6543
    Cell Significance Index: -35.8400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -1.6599
    Cell Significance Index: -21.7400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.6634
    Cell Significance Index: -19.1400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -1.6647
    Cell Significance Index: -19.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.6711
    Cell Significance Index: -19.9200
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -1.6728
    Cell Significance Index: -15.5900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -1.6836
    Cell Significance Index: -18.6900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.6838
    Cell Significance Index: -20.4100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -1.6845
    Cell Significance Index: -18.4100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -1.6859
    Cell Significance Index: -17.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -1.6925
    Cell Significance Index: -20.0000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.6975
    Cell Significance Index: -23.8100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -1.6990
    Cell Significance Index: -18.3200
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -1.7051
    Cell Significance Index: -18.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -1.7162
    Cell Significance Index: -20.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -1.7226
    Cell Significance Index: -22.6700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -1.7307
    Cell Significance Index: -18.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMSB4XP4 is a pseudogene, meaning it lacks the ability to encode a functional protein. However, it shares a high degree of sequence similarity with the TMSB4X gene, which encodes a protein involved in the regulation of immune responses. The expression of TMSB4XP4 is widespread, with significant levels detected in CD4-positive and CD8-positive alpha-beta thymocytes, alternatively activated macrophages, professional antigen-presenting cells, mesenchymal stem cells, embryonic stem cells, and various other cell types, including kidney loop of Henle epithelial cells and renal intercalated cells. **Pathways and Functions:** While TMSB4XP4 is a pseudogene, its expression is associated with several key signaling pathways, including the JAK-STAT pathway, which plays a crucial role in regulating immune responses. The TMSB4XP4 gene may influence the activation and function of immune cells, such as T cells and macrophages, by modulating the expression of genes involved in immune regulation. Additionally, TMSB4XP4 may participate in the regulation of cell growth and differentiation, particularly in stem cells. The functional significance of TMSB4XP4 is still unclear, but its expression in various cell types suggests that it may play a role in maintaining tissue homeostasis and regulating immune responses. Further studies are needed to elucidate the specific mechanisms by which TMSB4XP4 influences immune cell function and overall health. **Clinical Significance:** The expression of TMSB4XP4 in various cell types has significant implications for our understanding of immune-related diseases. For instance, the presence of TMSB4XP4 in CD4-positive and CD8-positive alpha-beta thymocytes suggests that it may play a role in the development and function of T cells, which are central to the adaptive immune response. Furthermore, the expression of TMSB4XP4 in mesenchymal stem cells and embryonic stem cells implies that it may be involved in the regulation of stem cell function and differentiation. Abnormal expression of TMSB4XP4 in these cell types may contribute to the development of various diseases, including autoimmune disorders and cancer. In addition, the expression of TMSB4XP4 in kidney loop of Henle epithelial cells and renal intercalated cells suggests that it may play a role in maintaining renal function and preventing disease. Further studies are needed to elucidate the specific mechanisms by which TMSB4XP4 influences renal function and overall health. In conclusion, the TMSB4XP4 gene is a pseudogene with widespread expression in immune cells and beyond. While its functional significance is still unclear, its expression in various cell types suggests that it may play a role in regulating immune responses, maintaining tissue homeostasis, and preventing disease. Further studies are needed to elucidate the specific mechanisms by which TMSB4XP4 influences immune cell function and overall health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.