Details for: OR3A3

Gene ID: 8392

Symbol: OR3A3

Ensembl ID: ENSG00000159961

Description: olfactory receptor family 3 subfamily A member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10815
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1176
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7562
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3656
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4826
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32732
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6
    Marker Score: 333
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 265
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.17
    Marker Score: 319
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.16
    Marker Score: 248
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.14
    Marker Score: 1890
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 267
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.13
    Marker Score: 202
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.11
    Marker Score: 84
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.11
    Marker Score: 138
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 805
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.09
    Marker Score: 93
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1254
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 456
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 680
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 93
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.06
    Marker Score: 76
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 94
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.05
    Marker Score: 54
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 3002
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.05
    Marker Score: 494
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 93
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.05
    Marker Score: 68
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.05
    Marker Score: 189
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.04
    Marker Score: 82
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.04
    Marker Score: 192
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 37
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.04
    Marker Score: 140
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.04
    Marker Score: 2378
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.04
    Marker Score: 78
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.03
    Marker Score: 1267
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1655
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 33

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** - OR3A3 is a type I olfactory receptor, which are responsible for detecting the sense of smell. - It is a transmembrane protein that is expressed in the olfactory epithelium of the nose and mouth. - OR3A3 is a multi-pass transmembrane protein, which means that it has multiple extracellular domains that can interact with different signaling molecules. - It is a member of the G protein-coupled receptor (GPCR) superfamily, which are a large family of proteins that are involved in the transmission of chemical signals across the cell membrane. **Pathways and functions** OR3A3 is involved in the following pathways and functions: - Detection of chemical stimulus involved in sensory perception of smell - Expression and translocation of olfactory receptors - G protein-coupled receptor activity - G protein-coupled receptor signaling pathway - Olfactory receptor activity - Olfactory signaling pathway **Clinical significance** Mutations in the OR3A3 gene have been linked to a number of human diseases, including: - Olfactory neuropathysm - Loss of smell - Inflammatory bowel disease - Cancer OR3A3 is a promising target for the development of new treatments for these diseases. By understanding the role of OR3A3 in sensory perception, it may be possible to develop new drugs that can restore smell in patients with olfactory neuropathysm and other diseases that affect the olfactory system.

Genular Protein ID: 3956290535

Symbol: OR3A3_HUMAN

Name: Olfactory receptor 3A3

UniProtKB Accession Codes:

P47888 Q2VPE4 Q6IFM6 Q9P1Q4 Q9UBE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 11 GO 4 Gene3D 1 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 321
  • Mass: 34963
  • Checksum: DA67FD99DE730A66
  • Sequence:
    • MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV 
EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD 
CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASWAC AFTNALTHTV AMSTLNFCGP 
NEVNHFYCDL PQLFQLSCSS TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA 
EGRKKAFSTC GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS 
LRNTDVQGAL CQLLVGKRSL T

Genular Protein ID: 554724767

Symbol: A0A126GWB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GWB3

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 2 SAM 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 315
  • Mass: 34262
  • Checksum: 69BC429E07A9C727
  • Sequence:
    • MEPEAGTNRT AVAEFILLGL VQTEEMQPVV FVLLLFAYLV TTGGNLSILA AVLVEPKLHA 
PMYFFLGNLS VLDVGCITVT VPAMLGRLLS HKSTISYDAC LSQLFFFHLL AGMDCFLLTA 
MAYDRLLAIC QPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNEVNHF 
YCDLPQLFQL SCSSTQLNEL LLFVAAAFMA VAPLVFISVS YAHVVAAVLQ IRSAEGRKKA 
FSTCGSHLTV VGIFYGTGVF SYMRLGSVES SDKDKGVGVF MTVINPMLNP LIYSLRNTDV 
QGALCQLLVG KRSLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.