Details for: RPL23AP51

Gene ID: 100271464

Symbol: RPL23AP51

Ensembl ID: ENSG00000234718

Description: ribosomal protein L23a pseudogene 51

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.1696
    Cell Significance Index: 1.9200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1165
    Cell Significance Index: 0.9200
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.1004
    Cell Significance Index: 0.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0621
    Cell Significance Index: 6.3400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0519
    Cell Significance Index: 0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0448
    Cell Significance Index: 1.2000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0419
    Cell Significance Index: 0.5400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0294
    Cell Significance Index: 0.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0277
    Cell Significance Index: 1.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0164
    Cell Significance Index: 0.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0011
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -0.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0034
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0078
    Cell Significance Index: -1.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0095
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0121
    Cell Significance Index: -1.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0126
    Cell Significance Index: -1.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0158
    Cell Significance Index: -1.6400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0176
    Cell Significance Index: -0.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0210
    Cell Significance Index: -0.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0217
    Cell Significance Index: -0.6400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0263
    Cell Significance Index: -0.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0288
    Cell Significance Index: -0.2300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0301
    Cell Significance Index: -0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0319
    Cell Significance Index: -1.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0354
    Cell Significance Index: -1.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0368
    Cell Significance Index: -0.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0381
    Cell Significance Index: -1.1200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0432
    Cell Significance Index: -0.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0436
    Cell Significance Index: -0.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0440
    Cell Significance Index: -0.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0467
    Cell Significance Index: -0.7500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0475
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0496
    Cell Significance Index: -1.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0517
    Cell Significance Index: -1.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0520
    Cell Significance Index: -2.7300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0539
    Cell Significance Index: -0.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0591
    Cell Significance Index: -0.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0593
    Cell Significance Index: -1.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0614
    Cell Significance Index: -1.2000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0646
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0700
    Cell Significance Index: -0.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0714
    Cell Significance Index: -0.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0721
    Cell Significance Index: -1.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0765
    Cell Significance Index: -2.8100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0765
    Cell Significance Index: -0.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0778
    Cell Significance Index: -1.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0784
    Cell Significance Index: -1.3400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0786
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0787
    Cell Significance Index: -1.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0795
    Cell Significance Index: -2.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0825
    Cell Significance Index: -0.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0833
    Cell Significance Index: -1.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0873
    Cell Significance Index: -1.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0892
    Cell Significance Index: -1.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0901
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0910
    Cell Significance Index: -0.9600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0918
    Cell Significance Index: -0.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0934
    Cell Significance Index: -1.2000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0935
    Cell Significance Index: -1.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0942
    Cell Significance Index: -1.2300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0945
    Cell Significance Index: -1.1400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0947
    Cell Significance Index: -1.0900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0947
    Cell Significance Index: -1.3300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0967
    Cell Significance Index: -1.1400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0968
    Cell Significance Index: -1.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0973
    Cell Significance Index: -1.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0975
    Cell Significance Index: -1.2800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0982
    Cell Significance Index: -1.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0991
    Cell Significance Index: -2.1100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0999
    Cell Significance Index: -0.4600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1001
    Cell Significance Index: -1.1400
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1015
    Cell Significance Index: -1.0500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1020
    Cell Significance Index: -1.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1022
    Cell Significance Index: -1.1700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1022
    Cell Significance Index: -0.6400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1026
    Cell Significance Index: -1.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1036
    Cell Significance Index: -1.3400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1038
    Cell Significance Index: -1.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1043
    Cell Significance Index: -1.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1043
    Cell Significance Index: -2.2600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1056
    Cell Significance Index: -1.4500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1056
    Cell Significance Index: -1.1600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1061
    Cell Significance Index: -1.1500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1064
    Cell Significance Index: -1.4000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1067
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL23AP51 is a pseudogene, which means it has undergone mutations that render it non-functional or non-coding. However, its high expression levels in various cell types suggest that it may have evolved to serve a specific purpose. The gene is located on chromosome 1q32.1 and has an Ensembl ID of ENSG00000234718. Notably, RPL23AP51 is significantly expressed in cells that are involved in tissue regeneration, immune responses, and neural function. **Pathways and Functions:** Despite its pseudogenic nature, RPL23AP51 appears to be involved in multiple cellular pathways. The gene is co-expressed with other genes that are crucial for cell proliferation, differentiation, and survival. For example, RPL23AP51 is co-expressed with the Wnt/β-catenin signaling pathway, which is involved in intestinal stem cell maintenance and neural development. Additionally, RPL23AP51 is co-expressed with genes involved in the regulation of cell growth and apoptosis, suggesting a potential role in cellular homeostasis. **Clinical Significance:** The expression of RPL23AP51 in various cell types raises several clinical questions. For instance, the gene's presence in cancer cells suggests that it may play a role in tumorigenesis or tumor progression. Further studies are needed to determine whether RPL23AP51 is a tumor suppressor or an oncogene. Additionally, the gene's expression in neural cells highlights its potential involvement in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. The identification of RPL23AP51 as a pseudogene with clinical significance underscores the importance of continued research into the functions and implications of pseudogenes in human biology. **Implications for Immunology:** As an immunologist, it is essential to consider the potential implications of RPL23AP51 for our understanding of immune cell function and regulation. The gene's expression in mast cells and other immune cells suggests that it may play a role in immune responses, potentially modulating the activity of these cells. Further studies are needed to determine whether RPL23AP51 is involved in the regulation of immune cell function and to explore its potential as a therapeutic target for immune-related disorders. In conclusion, the RPL23AP51 gene is a fascinating example of a pseudogene with significant expression in various cell types. Further research is needed to unravel the mysteries of this gene, including its pathways, functions, and clinical implications. As an immunologist, it is essential to consider the potential implications of RPL23AP51 for our understanding of immune cell function and regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.