Details for: LINC00561

Gene ID: 100861545

Symbol: LINC00561

Ensembl ID: ENSG00000261206

Description: long intergenic non-protein coding RNA 561

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3333
    Cell Significance Index: 3.4500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0809
    Cell Significance Index: 0.9400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0483
    Cell Significance Index: 0.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0192
    Cell Significance Index: 0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0121
    Cell Significance Index: 0.3300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0105
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0027
    Cell Significance Index: 0.0800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0045
    Cell Significance Index: -0.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0070
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0076
    Cell Significance Index: -0.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0082
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0132
    Cell Significance Index: -0.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0137
    Cell Significance Index: -0.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0149
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0157
    Cell Significance Index: -0.4200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0163
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0164
    Cell Significance Index: -0.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0173
    Cell Significance Index: -0.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0185
    Cell Significance Index: -0.3200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0194
    Cell Significance Index: -0.2700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0220
    Cell Significance Index: -0.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0236
    Cell Significance Index: -0.3800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0253
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0253
    Cell Significance Index: -0.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0260
    Cell Significance Index: -0.3500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0263
    Cell Significance Index: -0.4200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0264
    Cell Significance Index: -0.2800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0265
    Cell Significance Index: -0.3200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0266
    Cell Significance Index: -0.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0278
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0278
    Cell Significance Index: -0.3200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0285
    Cell Significance Index: -0.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0289
    Cell Significance Index: -0.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0297
    Cell Significance Index: -0.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0300
    Cell Significance Index: -0.3600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0301
    Cell Significance Index: -0.3300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0301
    Cell Significance Index: -0.3500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0307
    Cell Significance Index: -0.3700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0308
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0309
    Cell Significance Index: -0.2900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0312
    Cell Significance Index: -0.3700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0312
    Cell Significance Index: -0.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0313
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0315
    Cell Significance Index: -0.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0317
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0318
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0318
    Cell Significance Index: -0.3500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0322
    Cell Significance Index: -0.3700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0322
    Cell Significance Index: -0.3900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0326
    Cell Significance Index: -0.4100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0345
    Cell Significance Index: -0.4500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0351
    Cell Significance Index: -0.3500
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: -0.0351
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0355
    Cell Significance Index: -0.4200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0363
    Cell Significance Index: -0.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0366
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0366
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0376
    Cell Significance Index: -0.4100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0378
    Cell Significance Index: -0.4100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0382
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0382
    Cell Significance Index: -0.3200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0411
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0413
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0443
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0444
    Cell Significance Index: -0.4100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0484
    Cell Significance Index: -0.3600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0527
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0543
    Cell Significance Index: -0.3400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0574
    Cell Significance Index: -0.3800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0605
    Cell Significance Index: -0.3900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0642
    Cell Significance Index: -0.4600
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: -0.0750
    Cell Significance Index: -0.3700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0774
    Cell Significance Index: -0.4100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0799
    Cell Significance Index: -0.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00561 is a lincRNA, a class of non-coding RNAs that do not encode proteins but instead regulate gene expression through various mechanisms. It is characterized by its long length (approximately 2.6 kb) and lack of coding potential. LINC00561 is expressed in multiple cell types, including those involved in the nervous system, immune system, and hematopoiesis. Its expression is often associated with cellular differentiation, proliferation, and survival. **Pathways and Functions:** The functional mechanisms of LINC00561 are multifaceted and involve various signaling pathways. Research suggests that LINC00561 regulates gene expression by modulating the activity of transcription factors, such as enhancers and promoters. It can also interact with microRNAs (miRNAs) and other non-coding RNAs to influence gene expression. Specifically, LINC00561 has been implicated in: 1. **Regulation of cell proliferation and differentiation**: LINC00561 may influence the expression of genes involved in cell cycle progression and differentiation, particularly in the context of neural and hematopoietic development. 2. **Modulation of immune responses**: LINC00561 may regulate the expression of genes involved in immune cell function, including the activation and differentiation of T cells and dendritic cells. 3. **Inflammation and immune tolerance**: LINC00561 may also modulate the expression of genes involved in inflammation and immune tolerance, such as those involved in the regulation of cytokine production and immune cell function. **Clinical Significance:** The clinical significance of LINC00561 is an area of active research. Given its widespread expression in various cell types and its potential role in regulating cell proliferation, differentiation, and immune responses, LINC00561 may be involved in the pathogenesis of several diseases. Some potential clinical applications of LINC00561 include: 1. **Cancer diagnosis and treatment**: LINC00561 may serve as a biomarker for cancer diagnosis or as a target for cancer therapy. 2. **Immune-mediated disorders**: LINC00561 may play a role in the pathogenesis of autoimmune diseases, such as multiple sclerosis, and may be a potential target for immunotherapy. 3. **Neurological disorders**: LINC00561 may be involved in the regulation of gene expression in the nervous system, potentially contributing to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, LINC00561 is a non-coding RNA that plays a complex and multifaceted role in regulating gene expression in various cell types. Further research is needed to fully understand the mechanisms by which LINC00561 influences cell proliferation, differentiation, and immune responses, as well as its clinical significance in immunological and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.