Details for: C21orf140

Gene ID: 101928147

Symbol: C21orf140

Ensembl ID: ENSG00000222018

Description: chromosome 21 open reading frame 140

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0963
    Cell Significance Index: 1.6200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0343
    Cell Significance Index: 0.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0049
    Cell Significance Index: 0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0031
    Cell Significance Index: -0.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0036
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0050
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0054
    Cell Significance Index: -0.1800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0065
    Cell Significance Index: -0.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0067
    Cell Significance Index: -0.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0073
    Cell Significance Index: -0.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0074
    Cell Significance Index: -0.1500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0078
    Cell Significance Index: -0.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0080
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0093
    Cell Significance Index: -0.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0094
    Cell Significance Index: -0.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0095
    Cell Significance Index: -0.1900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0096
    Cell Significance Index: -0.1300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0098
    Cell Significance Index: -0.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0104
    Cell Significance Index: -0.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0105
    Cell Significance Index: -0.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0105
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0107
    Cell Significance Index: -0.1800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0112
    Cell Significance Index: -0.1000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0117
    Cell Significance Index: -0.1200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0120
    Cell Significance Index: -0.1100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0121
    Cell Significance Index: -0.1600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0123
    Cell Significance Index: -0.1300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0124
    Cell Significance Index: -0.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0124
    Cell Significance Index: -0.1700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0126
    Cell Significance Index: -0.1300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0127
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0131
    Cell Significance Index: -0.0700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0132
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0133
    Cell Significance Index: -0.1500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0136
    Cell Significance Index: -0.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0139
    Cell Significance Index: -0.1200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0142
    Cell Significance Index: -0.1200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0143
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0147
    Cell Significance Index: -0.1300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0148
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0160
    Cell Significance Index: -0.1100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0168
    Cell Significance Index: -0.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0172
    Cell Significance Index: -0.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0172
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0182
    Cell Significance Index: -0.2100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0194
    Cell Significance Index: -0.2300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0211
    Cell Significance Index: -0.1900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0211
    Cell Significance Index: -0.2200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0226
    Cell Significance Index: -0.2100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0261
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0263
    Cell Significance Index: -0.2500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0612
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C21orf140 is a non-coding gene, meaning it does not encode a protein. Instead, it is believed to play a regulatory role in gene expression, influencing the transcription of nearby genes. The gene is expressed in various cell types, including progenitor cells, endothelial cells, neuronal receptor cells, smooth muscle myoblasts, and oligodendrocyte precursor cells, among others. Its expression is also observed in specific cell types, such as CD4-positive T cells and pericytes, suggesting a role in immune function and vascular development. **Pathways and Functions:** C21orf140 is involved in several biological processes, including cellular differentiation, proliferation, and migration. Its expression is linked to the regulation of gene expression in various cell types, influencing the development and function of immune cells, blood vessels, and the nervous system. The gene's involvement in the regulation of gene expression suggests that it may play a role in the control of cell fate decisions, influencing the fate of progenitor cells and the development of specific cell types. Furthermore, C21orf140 is implicated in the regulation of immune responses, particularly in the context of T cell development and function. Its expression in CD4-positive T cells suggests that it may play a role in the regulation of T cell activation, proliferation, and differentiation. Additionally, its presence in pericytes, a type of endothelial cell, suggests that it may be involved in the regulation of vascular development and function. **Clinical Significance:** The clinical significance of C21orf140 is still largely unknown, as its expression is limited to specific cell types and tissues. However, its involvement in immune function and cellular differentiation suggests that dysregulation of this gene may contribute to various diseases, including autoimmune disorders, cancer, and vascular diseases. Further research is needed to fully elucidate the role of C21orf140 in human disease. However, its expression in specific cell types and tissues suggests that it may be a valuable target for the development of novel therapeutic strategies. Additionally, the gene's involvement in the regulation of gene expression suggests that it may be a useful tool for studying gene regulation and cellular differentiation. In conclusion, C21orf140 is a mysterious gene with a complex and multifaceted role in various biological processes. Further research is needed to fully understand its functions and clinical significance, but its intriguing characteristics and pathways suggest that it may be a valuable target for the development of novel therapeutic strategies.

Genular Protein ID: 3939670309

Symbol: F243A_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9A014

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 GeneCards 1 GeneTree 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 3 STRING 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 251
  • Mass: 29214
  • Checksum: 6B131B1C92FBA015
  • Sequence:
    • MPRFASPLLR NVIIRSQFDG IKRKQCLQYL KTLRTLQYDG FKTVYFGETN IPESLVTGED 
ISDGYFIQTP TWCIVHAAGS QGWVPWKYRV FLRDELCIKQ EDSLFSEFCD VVRKAYGKCV 
IVVKERRQQE EQRPKEDREA EGQFYIPTVI SLASIMCCPE VAKSCGHELL SLPSPCNYLN 
PLDSAWSSLK WFIINNRNEF CLQSIDSGYS YQCILFSNLI SKGIERINAS KWRTLTSKVR 
RWENYYLGKF S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.