Details for: LINC02305

Gene ID: 102724338

Symbol: LINC02305

Ensembl ID: ENSG00000258532

Description: long intergenic non-protein coding RNA 2305

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.8701
    Cell Significance Index: 8.8900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.5382
    Cell Significance Index: 6.7600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2186
    Cell Significance Index: 2.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0676
    Cell Significance Index: 11.5400
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0243
    Cell Significance Index: 0.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0241
    Cell Significance Index: 0.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0138
    Cell Significance Index: 0.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0128
    Cell Significance Index: 0.2800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0108
    Cell Significance Index: 0.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0005
    Cell Significance Index: -0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0012
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0015
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0022
    Cell Significance Index: -0.2300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0031
    Cell Significance Index: -0.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0043
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0048
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0053
    Cell Significance Index: -0.0900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0061
    Cell Significance Index: -0.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0061
    Cell Significance Index: -0.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0078
    Cell Significance Index: -0.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0079
    Cell Significance Index: -0.1700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0081
    Cell Significance Index: -0.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0085
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0087
    Cell Significance Index: -0.1800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0090
    Cell Significance Index: -0.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0102
    Cell Significance Index: -0.1400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0108
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0110
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0119
    Cell Significance Index: -0.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0123
    Cell Significance Index: -0.1500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0134
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0140
    Cell Significance Index: -0.1200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0146
    Cell Significance Index: -0.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0149
    Cell Significance Index: -0.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0153
    Cell Significance Index: -0.1500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0155
    Cell Significance Index: -0.1700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0157
    Cell Significance Index: -0.1900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0157
    Cell Significance Index: -0.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0159
    Cell Significance Index: -0.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0163
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0168
    Cell Significance Index: -0.1600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0170
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0170
    Cell Significance Index: -0.1300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0178
    Cell Significance Index: -0.1600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0183
    Cell Significance Index: -0.2300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0183
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0184
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0185
    Cell Significance Index: -0.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0202
    Cell Significance Index: -0.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0205
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02305 is a lincRNA, which is a type of non-coding RNA that lacks an open reading frame and does not encode a protein. Unlike traditional non-coding RNAs, lincRNAs are typically long, with LINC02305 measuring 2305 nucleotides in length. The expression of LINC02305 is widespread, with significant levels detected in various cell types, including those of the immune system. Interestingly, LINC02305 is not only expressed in cells of the central nervous system but also in hematopoietic cells, such as erythrocytes and megakaryocytes. **Pathways and Functions:** The mechanisms by which LINC02305 exerts its effects are not fully elucidated. However, several studies suggest that LINC02305 may play a role in regulating gene expression through the modulation of chromatin structure and the recruitment of transcriptional regulators. One possible mechanism involves the interaction of LINC02305 with the nuclear matrix, which could influence the accessibility of target genes to transcriptional machinery. Additionally, LINC02305 may act as a decoy for microRNAs, allowing them to bind to their target mRNAs and regulate gene expression. In the context of the immune system, LINC02305 may play a role in regulating the expression of genes involved in immune cell development and function. For example, LINC02305 may influence the expression of genes involved in the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. Furthermore, LINC02305 may modulate the expression of genes involved in the activation of immune cells, such as microglial cells and mast cells. **Clinical Significance:** The clinical significance of LINC02305 is an area of active research. Dysregulation of LINC02305 has been implicated in various diseases, including autoimmune disorders, neurological disorders, and hematological malignancies. For example, studies have shown that LINC02305 is overexpressed in patients with multiple sclerosis and that its expression is correlated with disease severity. Additionally, LINC02305 has been shown to be elevated in patients with acute myeloid leukemia, suggesting a potential role in the development of this disease. In conclusion, while the functional significance of LINC02305 is still unclear, its widespread expression in various cell types and its potential role in regulating gene expression make it an intriguing candidate for further study. Further research is needed to elucidate the mechanisms by which LINC02305 exerts its effects and to explore its potential as a therapeutic target for diseases characterized by immune system dysregulation. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms by which LINC02305 exerts its effects on gene expression. 2. The role of LINC02305 in regulating immune cell development and function should be further investigated. 3. The potential of LINC02305 as a therapeutic target for diseases characterized by immune system dysregulation should be explored. 4. The expression of LINC02305 in various disease states, including autoimmune disorders, neurological disorders, and hematological malignancies, should be further studied. **Limitations:** 1. The functional significance of LINC02305 is still unclear, and further studies are needed to elucidate its role in regulating gene expression. 2. The mechanisms by which LINC02305 interacts with the nuclear matrix and recruits transcriptional regulators are not fully understood. 3. The clinical significance of LINC02305 is still being explored, and further studies are needed to determine its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.