Details for: LINC01745

Gene ID: 105373199

Symbol: LINC01745

Ensembl ID: ENSG00000225919

Description: long intergenic non-protein coding RNA 1745

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7105
    Cell Significance Index: 7.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2104
    Cell Significance Index: 3.4100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1743
    Cell Significance Index: 2.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0586
    Cell Significance Index: 1.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0354
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0328
    Cell Significance Index: 0.3500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0245
    Cell Significance Index: 0.3100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0233
    Cell Significance Index: 0.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0215
    Cell Significance Index: 0.2900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0202
    Cell Significance Index: 0.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0196
    Cell Significance Index: 0.4300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0160
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0153
    Cell Significance Index: 0.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0110
    Cell Significance Index: 0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0076
    Cell Significance Index: 0.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0057
    Cell Significance Index: 0.0800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0040
    Cell Significance Index: 0.0400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0016
    Cell Significance Index: 0.0200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0003
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0014
    Cell Significance Index: -0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0022
    Cell Significance Index: -0.3200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0046
    Cell Significance Index: -0.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0060
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0061
    Cell Significance Index: -0.2000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0081
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0094
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0106
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0108
    Cell Significance Index: -0.1400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0108
    Cell Significance Index: -0.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0118
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0119
    Cell Significance Index: -0.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0121
    Cell Significance Index: -0.2100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0121
    Cell Significance Index: -0.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0141
    Cell Significance Index: -0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0142
    Cell Significance Index: -0.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0151
    Cell Significance Index: -0.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0154
    Cell Significance Index: -0.1800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0163
    Cell Significance Index: -0.2200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0172
    Cell Significance Index: -0.1000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0173
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0192
    Cell Significance Index: -0.2500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0200
    Cell Significance Index: -0.2500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0206
    Cell Significance Index: -0.2100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0216
    Cell Significance Index: -0.2400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0228
    Cell Significance Index: -0.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0229
    Cell Significance Index: -0.2800
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0230
    Cell Significance Index: -0.2100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0241
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0242
    Cell Significance Index: -0.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0244
    Cell Significance Index: -0.2500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0265
    Cell Significance Index: -0.2300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0280
    Cell Significance Index: -0.1500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0290
    Cell Significance Index: -0.2400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0294
    Cell Significance Index: -0.2400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0319
    Cell Significance Index: -0.2300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0397
    Cell Significance Index: -0.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0410
    Cell Significance Index: -0.2400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0429
    Cell Significance Index: -0.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: LINC01745 is an intergenic non-protein coding RNA, meaning it does not encode a protein but instead regulates gene expression through various mechanisms. 2. **Long non-coding RNA (lncRNA)**: LINC01745 belongs to the class of long non-coding RNAs, which are RNAs longer than 200 nucleotides that do not encode proteins. 3. **Cell-type specific expression**: LINC01745 is significantly expressed in a range of cell types, including immune cells, progenitor cells, and hematopoietic stem cells, suggesting its involvement in cellular development and differentiation. 4. **Regulatory function**: LINC01745 is likely to regulate gene expression by influencing chromatin structure, transcription factor activity, or microRNA-mediated gene silencing. **Pathways and Functions:** 1. **Immune cell development and function**: LINC01745 may play a role in the development and differentiation of immune cells, such as T cells, B cells, and dendritic cells, which are essential for the adaptive immune response. 2. **Cellular differentiation and proliferation**: LINC01745 may regulate the expression of genes involved in cellular differentiation and proliferation, influencing the development of various cell types, including hematopoietic stem cells and progenitor cells. 3. **Chromatin remodeling and gene regulation**: LINC01745 may interact with chromatin remodeling complexes to regulate gene expression, influencing the transcriptional activity of key genes involved in immune responses and cellular development. 4. **MicroRNA-mediated regulation**: LINC01745 may act as a microRNA (miRNA) regulator, influencing the expression of miRNAs that target specific genes involved in immune responses and cellular development. **Clinical Significance:** 1. **Immune-related disorders**: Dysregulation of LINC01745 expression has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and infectious diseases. 2. **Cancer progression**: LINC01745 may contribute to cancer progression by regulating the expression of genes involved in cell proliferation, differentiation, and survival. 3. **Infectious diseases**: LINC01745 may play a role in the regulation of immune responses to infectious diseases, influencing the expression of genes involved in inflammation, cytokine production, and immune cell activation. 4. **Therapeutic targets**: Understanding the regulatory functions of LINC01745 may lead to the identification of novel therapeutic targets for the treatment of immune-related disorders, cancer, and infectious diseases. In conclusion, LINC01745 is a multifaceted gene with significant implications for our understanding of the immune system and its role in various diseases. Further research is needed to elucidate the mechanisms by which LINC01745 regulates gene expression and its involvement in immune-related disorders, cancer, and infectious diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.