Details for: ZNRF4

Gene ID: 148066

Symbol: ZNRF4

Ensembl ID: ENSG00000105428

Description: zinc and ring finger 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6961
    Cell Significance Index: 41.0900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.9580
    Cell Significance Index: 10.6100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3149
    Cell Significance Index: 4.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0868
    Cell Significance Index: 1.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0705
    Cell Significance Index: 0.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0698
    Cell Significance Index: 1.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0203
    Cell Significance Index: 0.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0040
    Cell Significance Index: 0.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0007
    Cell Significance Index: -0.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0011
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0036
    Cell Significance Index: -1.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0040
    Cell Significance Index: -0.0600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0103
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0110
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0161
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0204
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0236
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0237
    Cell Significance Index: -0.7600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0240
    Cell Significance Index: -0.1900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0258
    Cell Significance Index: -0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0261
    Cell Significance Index: -0.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0263
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0264
    Cell Significance Index: -0.3600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0278
    Cell Significance Index: -0.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0280
    Cell Significance Index: -0.3400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0280
    Cell Significance Index: -0.3600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0295
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0301
    Cell Significance Index: -0.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0317
    Cell Significance Index: -0.5300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0320
    Cell Significance Index: -0.2800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0326
    Cell Significance Index: -0.4300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0327
    Cell Significance Index: -0.4100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0329
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0337
    Cell Significance Index: -0.8400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0340
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0342
    Cell Significance Index: -0.4700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0343
    Cell Significance Index: -0.4500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0354
    Cell Significance Index: -0.4000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0356
    Cell Significance Index: -0.3700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0372
    Cell Significance Index: -0.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0380
    Cell Significance Index: -0.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0386
    Cell Significance Index: -0.4600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0387
    Cell Significance Index: -0.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0396
    Cell Significance Index: -0.8400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0400
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0413
    Cell Significance Index: -0.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0417
    Cell Significance Index: -0.8700
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: -0.0419
    Cell Significance Index: -0.5100
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0423
    Cell Significance Index: -0.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0425
    Cell Significance Index: -0.8400
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.0425
    Cell Significance Index: -0.5200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0431
    Cell Significance Index: -0.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0432
    Cell Significance Index: -0.8500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0433
    Cell Significance Index: -0.3900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0446
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0448
    Cell Significance Index: -0.4100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0450
    Cell Significance Index: -0.3800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0454
    Cell Significance Index: -0.9100
  • Cell Name: OFFx cell (CL4033036)
    Fold Change: -0.0458
    Cell Significance Index: -0.5200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0461
    Cell Significance Index: -0.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0465
    Cell Significance Index: -0.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0486
    Cell Significance Index: -0.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0487
    Cell Significance Index: -0.6500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0488
    Cell Significance Index: -0.6000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0501
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0511
    Cell Significance Index: -0.4800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0529
    Cell Significance Index: -0.5800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0547
    Cell Significance Index: -0.5600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0555
    Cell Significance Index: -0.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0559
    Cell Significance Index: -1.3400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0578
    Cell Significance Index: -0.6100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0582
    Cell Significance Index: -0.7400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0591
    Cell Significance Index: -0.6900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0594
    Cell Significance Index: -0.4900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0600
    Cell Significance Index: -0.4000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0606
    Cell Significance Index: -0.6900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0620
    Cell Significance Index: -0.7100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0643
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0646
    Cell Significance Index: -0.6600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0661
    Cell Significance Index: -0.7900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0667
    Cell Significance Index: -0.8700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0682
    Cell Significance Index: -0.6200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0682
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNRF4 is a small, 104-amino acid protein that belongs to the RING-type E3 ubiquitin transferase family. It is characterized by its ability to bind to ubiquitin and transfer it to target proteins, marking them for degradation. ZNRF4 is highly expressed in various cell types, including immune cells, endothelial cells, and progenitor cells. Its expression is often upregulated in response to cellular stress, inflammation, or oxidative damage. **Pathways and Functions:** ZNRF4 is involved in several key cellular pathways, including: 1. **Negative regulation of cell cycle:** ZNRF4 can inhibit cell cycle progression by targeting and degrading proteins involved in cell cycle regulation. 2. **Negative regulation of nucleotide-binding oligomerization domain-containing 2 (NOD2) signaling pathway:** ZNRF4 can inhibit NOD2-mediated signaling, which is involved in innate immune responses to bacterial and fungal pathogens. 3. **Proteasome-mediated ubiquitin-dependent protein catabolic process:** ZNRF4 can regulate protein degradation through the ubiquitin-proteasome pathway, which is essential for maintaining protein homeostasis. 4. **Protein binding and ubiquitination:** ZNRF4 can bind to and ubiquitinate target proteins, marking them for degradation or altering their activity. **Clinical Significance:** ZNRF4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** ZNRF4 has been shown to be overexpressed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may contribute to the development of autoimmunity. 2. **Cancer:** ZNRF4 has been identified as a tumor suppressor gene, as it can inhibit cell growth and induce apoptosis in cancer cells. 3. **Neurodegenerative diseases:** ZNRF4 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the development of neuroinflammation and neuronal degeneration. 4. **Infectious diseases:** ZNRF4 has been shown to be involved in the regulation of immune responses to bacterial and fungal pathogens, suggesting its potential as a therapeutic target for infectious diseases. In conclusion, ZNRF4 is a critical gene involved in regulating immune responses, cell cycle, and protein degradation. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into its clinical significance and potential therapeutic applications.

Genular Protein ID: 3945105539

Symbol: ZNRF4_HUMAN

Name: RING-type E3 ubiquitin transferase ZNRF4

UniProtKB Accession Codes:

Q8WWF5 A8K886 O75866

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 EC 1 EMBL 4 Ensembl 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21205830

Title: A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis.

PubMed ID: 21205830

DOI: 10.1074/jbc.m110.197459

PubMed ID: 24387786

Title: Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization.

PubMed ID: 24387786

DOI: 10.1042/bj20131067

PubMed ID: 28656966

Title: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

PubMed ID: 28656966

DOI: 10.1038/ncomms15865

Sequence Information:

  • Length: 429
  • Mass: 46958
  • Checksum: 9924ED37BC00644D
  • Sequence:
    • MPLCRPEHLM PRASRVPVAA SLPLSHAVIP TQLPSRPGHR PPGRPRRCPK ASCLPPPVGP 
SSTQTAKRVT MGWPRPGRAL VAVKALLVLS LLQVPAQAVV RAVLEDNSSS VDFADLPALF 
GVPLAPEGIR GYLMEVKPAN ACHPIEAPRL GNRSLGAIVL IRRYDCTFDL KVLNAQRAGF 
EAAIVHNVHS DDLVSMTHVY EDLRGQIAIP SVFVSEAASQ DLRVILGCNK SAHALLLPDD 
PPCHDLGCHP VLTVSWVLGC TLALVVSAFF VLNHLWLWAQ ACCSHRRPVK TSTCQKAQVR 
TFTWHNDLCA ICLDEYEEGD QLKILPCSHT YHCKCIDPWF SQAPRRSCPV CKQSVAATED 
SFDSTTYSFR DEDPSLPGHR PPIWAIQVQL RSRRLELLGR ASPHCHCSTT SLEAEYTTVS 
SAPPEAPGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.