Details for: CYP8B1

Gene ID: 1582

Symbol: CYP8B1

Ensembl ID: ENSG00000180432

Description: cytochrome P450 family 8 subfamily B member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 11.53
    Marker Score: 12675
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2237.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.86
    Marker Score: 2072
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.78
    Marker Score: 1704
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.23
    Marker Score: 5317
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.17
    Marker Score: 801
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7478
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.04
    Marker Score: 6704
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.03
    Marker Score: 5562
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2072
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.57
    Marker Score: 709
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 545
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 439
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.54
    Marker Score: 578
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.54
    Marker Score: 8434
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 897
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.43
    Marker Score: 134
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 664.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.41
    Marker Score: 156
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.41
    Marker Score: 238
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.41
    Marker Score: 1329
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.37
    Marker Score: 137
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.35
    Marker Score: 1005
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.33
    Marker Score: 665
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.3
    Marker Score: 1054
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.29
    Marker Score: 291
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 154
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 204
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.22
    Marker Score: 717
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.21
    Marker Score: 229
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1134
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.18
    Marker Score: 253
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.15
    Marker Score: 162
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 28
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 159
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 253
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 145
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.11
    Marker Score: 171.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 63
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1
    Marker Score: 288
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 95
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 160
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 45
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.06
    Marker Score: 163.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.06
    Marker Score: 29

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Other Information

**Key characteristics:** - The CYP8B1 gene is located on chromosome 15q21.1. - It is a large gene, encoding a protein of 1,207 amino acids. - CYP8B1 is expressed in a variety of cell types, including glial cells, blood vessel endothelial cells, plasma cells, retina horizontal cells, midzonal region hepatocyte, hepatocyte, goblet cells, centrilobular region hepatocyte, and periportal region hepatocyte. **Pathways and functions:** - CYP8B1 is involved in a variety of metabolic pathways, including arachidonic acid metabolism, bile acid and bile salt metabolism, biological oxidations, cytochrome p450 - arranged by substrate type, eicosanoids, endogenous sterols, fatty acid metabolism, metabolism, metabolism of lipids, metabolism of steroids, metabolism of vitamins and cofactors, metabolism of water-soluble vitamins and cofactors, and nicotinamide salvaging. **Clinical significance:** - Mutations in the CYP8B1 gene have been linked to several human diseases, including cholestatic liver disease, gallstones, and bile duct stones. - CYP8B1 inhibitors are being investigated as potential treatments for these diseases. - By understanding the role of CYP8B1 in metabolism, researchers may be able to develop new therapies for these diseases.

Genular Protein ID: 1698509232

Symbol: CP8B1_HUMAN

Name: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

UniProtKB Accession Codes:

Q9UNU6 B2RCY3 O75958 Q6NWT2 Q6NWT3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIRSF 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10051404

Title: Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.

PubMed ID: 10051404

DOI: 10.1006/geno.1998.5606

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 501
  • Mass: 58068
  • Checksum: 1B97698E8453E51A
  • Sequence:
    • MVLWGPVLGA LLVVIAGYLC LPGMLRQRRP WEPPLDKGTV PWLGHAMAFR KNMFEFLKRM 
RTKHGDVFTV QLGGQYFTFV MDPLSFGSIL KDTQRKLDFG QYAKKLVLKV FGYRSVQGDH 
EMIHSASTKH LRGDGLKDLN ETMLDSLSFV MLTSKGWSLD ASCWHEDSLF RFCYYILFTA 
GYLSLFGYTK DKEQDLLQAG ELFMEFRKFD LLFPRFVYSL LWPREWLEVG RLQRLFHKML 
SVSHSQEKEG ISNWLGNMLQ FLREQGVPSA MQDKFNFMML WASQGNTGPT SFWALLYLLK 
HPEAIRAVRE EATQVLGEAR LETKQSFAFK LGALQHTPVL DSVVEETLRL RAAPTLLRLV 
HEDYTLKMSS GQEYLFRHGD ILALFPYLSV HMDPDIHPEP TVFKYDRFLN PNGSRKVDFF 
KTGKKIHHYT MPWGSGVSIC PGRFFALSEV KLFILLMVTH FDLELVDPDT PLPHVDPQRW 
GFGTMQPSHD VRFRYRLHPT E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.