Details for: DLG4

Gene ID: 1742

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DLG4

Ensembl ID: ENSG00000132535

Description: discs large MAGUK scaffold protein 4

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • retinal cone cell CL0000573
    CSI 9.54
    rCSI 15.36%
    PRS 71.69
  • progenitor cell CL0011026
    CSI 8.95
    rCSI 19.03%
    PRS 75.46
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 6.34
    rCSI 11.2%
    PRS 63.2
  • S cone cell CL0003050
    CSI 4.65
    rCSI 20.42%
    PRS 76.19
  • VIP GABAergic cortical interneuron CL4023016
    CSI 4.42
    rCSI 5.28%
    PRS 63.92
  • mature astrocyte CL0002627
    CSI 3.49
    rCSI 14.84%
    PRS 73.82
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 3.42
    rCSI 5.74%
    PRS 63.74
  • interneuron CL0000099
    CSI 3.26
    rCSI 6.55%
    PRS 71.91
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.02
    rCSI 6.77%
    PRS 64.59
  • ON-bipolar cell CL0000749
    CSI 2.94
    rCSI 4.37%
    PRS 81.06
  • cerebral cortex neuron CL0010012
    CSI 2.76
    rCSI 11.24%
    PRS 73.4
  • retinal pigment epithelial cell CL0002586
    CSI 2.52
    rCSI 5.01%
    PRS 77.06
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.42
    rCSI 2.79%
    PRS 73.48
  • choroid plexus epithelial cell CL0000706
    CSI 2.41
    rCSI 3.95%
    PRS 71.07
  • inhibitory interneuron CL0000498
    CSI 2.41
    rCSI 5.57%
    PRS 69.6
  • retinal rod cell CL0000604
    CSI 2.39
    rCSI 4.21%
    PRS 76.75
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.37
    rCSI 4.31%
    PRS 73.04
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.33
    rCSI 2.9%
    PRS 61.67
  • rod bipolar cell CL0000751
    CSI 2.33
    rCSI 4.18%
    PRS 74.78
  • OFF-bipolar cell CL0000750
    CSI 2.3
    rCSI 3.15%
    PRS 82.89
  • retinal bipolar neuron CL0000748
    CSI 2.05
    rCSI 3.83%
    PRS 69.93
  • medium spiny neuron CL1001474
    CSI 2.04
    rCSI 17.57%
    PRS 69.64
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.92
    rCSI 2.47%
    PRS 64.99
  • peripheral nervous system neuron CL2000032
    CSI 1.79
    rCSI 2.44%
    PRS 73.15
  • eye photoreceptor cell CL0000287
    CSI 1.47
    rCSI 16.57%
    PRS 88.63
  • cerebellar neuron CL1001611
    CSI 1.44
    rCSI 12.64%
    PRS 69.62
  • retina horizontal cell CL0000745
    CSI 1.41
    rCSI 2.15%
    PRS 78.18
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.19
    rCSI 1.92%
    PRS 65.33
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.15
    rCSI 2.49%
    PRS 69.13
  • retinal ganglion cell CL0000740
    CSI 1.1
    rCSI 2.42%
    PRS 67.41
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.06
    rCSI 2.53%
    PRS 68.26
  • basket cell CL0000118
    CSI 0.99
    rCSI 6.19%
    PRS 61.42
  • amacrine cell CL0000561
    CSI 0.91
    rCSI 2.63%
    PRS 71.13
  • dopaminergic neuron CL0000700
    CSI 0.87
    rCSI 4.94%
    PRS 67.67
  • direct pathway medium spiny neuron CL4023026
    CSI 0.85
    rCSI 20.27%
    PRS 61.87
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.8
    rCSI 19.29%
    PRS 62.44
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.65
    rCSI 2.14%
    PRS 67.31
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.64
    rCSI 1.99%
    PRS 67.77
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.6
    rCSI 2.27%
    PRS 64.33
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.58
    rCSI 1.8%
    PRS 65.42
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.57
    rCSI 1.38%
    PRS 61.75
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.55
    rCSI 1.98%
    PRS 61.71
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.29
    rCSI 1.69%
    PRS 64.4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DLG4](/details-gene/1742) (Discs Large MAGUK Scaffold Protein 4), also widely known as Postsynaptic Density protein 95 (PSD-95), is a pivotal scaffolding protein essential for the organization and function of excitatory synapses. It belongs to the membrane-associated guanylate kinase (MAGUK) family and plays a crucial role in clustering and anchoring neurotransmitter receptors, ion channels, and signaling molecules at the postsynaptic density. **Overall**, its expression is highest in cells of the central nervous system, particularly neuronal subtypes such as the [retinal cone cell](/details-cell/CL0000573) and various cortical interneurons, underscoring its fundamental role in synaptic transmission, plasticity, learning, and memory. Clinical associations with [DLG4](/details-gene/1742) ([602887](https://omim.org/entry/602887)) highlight its importance in human neurodevelopment and neurological health. ## Cellular Roles and Expression Landscape The expression profile of [DLG4](/details-gene/1742) firmly establishes its identity as a key architectural component of the nervous system. The **Overall** context shows its highest significance in highly specialized neuronal and photoreceptor cells. It is a defining marker for the [retinal cone cell](/details-cell/CL0000573) (CSI: 9.54) and [S cone cell](/details-cell/CL0003050) (CSI: 4.65), suggesting a critical role in organizing the complex signaling machinery of phototransduction at the photoreceptor synapse. Within the brain, [DLG4](/details-gene/1742) shows prominent significance in various subtypes of [interneuron](/details-cell/CL0000099)s, including [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064) (CSI: 6.34) and [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 4.42). This indicates its importance not only in principal excitatory neurons but also in the regulation of inhibitory circuits that are vital for cognitive function. Its high significance in developmental cell types like [progenitor cell](/details-cell/CL0011026) (CSI: 8.95) is consistent with its established role in nervous system development. Furthermore, notable expression in glial cells, such as [mature astrocyte](/details-cell/CL0002627) (CSI: 3.49) and [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 3.02), suggests a role in the tripartite synapse, where astrocytes actively participate in synaptic function and maintenance. ## Pathways and Molecular Function The functional annotations for [DLG4](/details-gene/1742) are extensively linked to the formation and modulation of synapses. It is a central player in '[Chemical synaptic transmission](https://www.ebi.ac.uk/QuickGO/term/GO:0007268)' and '[Neurotransmitter receptors and postsynaptic signal transmission](https://reactome.org/content/detail/R-HSA-112314)'. Its primary molecular function is to act as a scaffold, evident from its involvement in '[Scaffold protein binding](https://www.ebi.ac.uk/QuickGO/term/GO:0097110)' and numerous binding interactions with key synaptic proteins, including glutamate receptors ([GO:0035255](https://www.ebi.ac.uk/QuickGO/term/GO:0035255)) and neuroligins ([GO:0097109](https://www.ebi.ac.uk/QuickGO/term/GO:0097109)), as demonstrated in early studies [Link](https://doi.org/10.1126/science.277.5331.1511). Reactome pathway analysis further details its role in excitatory neurotransmission, particularly through its involvement in '[Activation of nmda receptors and postsynaptic events](https://reactome.org/content/detail/R-HSA-442755)' and '[Glutamate binding, activation of ampa receptors and synaptic plasticity](https://reactome.org/content/detail/R-HSA-399721)'. These functions are the molecular basis for higher-order processes such as '[Regulation of long-term neuronal synaptic plasticity](https://www.ebi.ac.uk/QuickGO/term/GO:0048169)' and '[Learning](https://www.ebi.ac.uk/QuickGO/term/GO:0007612)'. The localization of [DLG4](/details-gene/1742) to the '[Postsynaptic density](https://www.ebi.ac.uk/QuickGO/term/GO:0014069)' is central to its ability to orchestrate these events, physically linking neurotransmitter receptors to downstream signaling cascades and the cytoskeleton, which is crucial for processes like '[Dendritic spine morphogenesis](https://www.ebi.ac.uk/QuickGO/term/GO:0060997)' [Link](https://doi.org/10.1523/jneurosci.3112-08.2008). ## Research Directions Given the central role of [DLG4](/details-gene/1742) in synaptic integrity and plasticity, research should focus on how its dysfunction in specific cell types contributes to neurological and psychiatric disorders. ### Proposed Hypotheses: 1. **Hypothesis 1:** Cell-type-specific disruption of [DLG4](/details-gene/1742) interactions with neuroligins in cortical interneurons, such as [VIP GABAergic cortical interneuron](/details-cell/CL4023016), may lead to an excitatory/inhibitory imbalance that underlies social behavior deficits observed in some forms of autism spectrum disorder. 2. **Hypothesis 2:** The high significance of [DLG4](/details-gene/1742) in [retinal cone cell](/details-cell/CL0000573)s suggests it is a master organizer of the ribbon synapse. Age-related decline in [DLG4](/details-gene/1742) expression or function could destabilize this synapse, contributing to the progressive vision loss seen in retinal degenerative diseases. ### Experimental Approach: To test Hypothesis 1, a conditional knockout mouse model could be generated to specifically delete [DLG4](/details-gene/1742) in VIP-expressing interneurons using a VIP-Cre driver line. Electrophysiological recordings (e.g., patch-clamp) from cortical slices could then be used to assess synaptic transmission and plasticity in circuits involving these neurons. Co-immunoprecipitation and proximity ligation assays from isolated VIP interneurons could confirm the disruption of the DLG4-neuroligin complex. These molecular and cellular analyses would be correlated with a battery of behavioral tests assessing social interaction and cognitive flexibility in the knockout animals. ### Therapeutic Potential: As an intracellular scaffolding protein without enzymatic activity, [DLG4](/details-gene/1742) is a challenging direct drug target. However, its numerous protein-protein interactions represent viable therapeutic nodes. Strategies could focus on developing cell-permeable peptides or small molecules that specifically disrupt or stabilize key interactions, such as its binding to NMDA receptors, which is implicated in excitotoxicity after stroke. For neurodevelopmental disorders associated with [DLG4](/details-gene/1742) haploinsufficiency, gene therapy approaches aimed at restoring its expression levels in affected neuronal populations could be a long-term possibility. Therapeutic intervention would likely require high specificity to avoid disrupting the widespread and essential functions of [DLG4](/details-gene/1742) throughout the central nervous system.

Genular Protein ID: 2130270879

Symbol: DLG4_HUMAN

Name: Disks large homolog 4

UniProtKB Accession Codes:

P78352 B7Z1S1 G5E939 Q92941 Q9UKK8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 68 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 14 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9286702

Title: Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.

PubMed ID: 9286702

DOI: 10.1006/geno.1997.4848

PubMed ID: 10582582

Title: Genomic organization of human DLG4, the gene encoding postsynaptic density 95.

PubMed ID: 10582582

DOI: 10.1046/j.1471-4159.1999.0732250.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 7477295

Title: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.

PubMed ID: 7477295

DOI: 10.1038/378085a0

PubMed ID: 9278515

Title: Binding of neuroligins to PSD-95.

PubMed ID: 9278515

DOI: 10.1126/science.277.5331.1511

PubMed ID: 10859302

Title: GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.

PubMed ID: 10859302

DOI: 10.1074/jbc.m000715200

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 12151521

Title: Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.

PubMed ID: 12151521

DOI: 10.1523/jneurosci.22-15-06415.2002

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 19118189

Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

PubMed ID: 19118189

DOI: 10.1523/jneurosci.3112-08.2008

PubMed ID: 20962234

Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

PubMed ID: 20962234

DOI: 10.1523/jneurosci.1711-10.2010

PubMed ID: 21119615

Title: DGKiota regulates presynaptic release during mGluR-dependent LTD.

PubMed ID: 21119615

DOI: 10.1038/emboj.2010.286

PubMed ID: 23782696

Title: Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.

PubMed ID: 23782696

DOI: 10.1074/jbc.m113.489757

PubMed ID: 26701913

Title: ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.

PubMed ID: 26701913

DOI: 10.7554/elife.11306

PubMed ID: 25780553

Title: The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.

PubMed ID: 25780553

DOI: 10.1186/s13229-015-0012-5

PubMed ID: 26334723

Title: Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.

PubMed ID: 26334723

DOI: 10.1038/ncomms9200

PubMed ID: 27066583

Title: Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.

PubMed ID: 27066583

DOI: 10.1212/nxg.0000000000000046

PubMed ID: 27479843

Title: Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.

PubMed ID: 27479843

DOI: 10.1038/nn.4352

PubMed ID: 29460436

Title: Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features.

PubMed ID: 29460436

DOI: 10.1111/cge.13243

PubMed ID: 11744724

Title: The PDZ1 domain of SAP90. Characterization of structure and binding.

PubMed ID: 11744724

DOI: 10.1074/jbc.m109453200

Sequence Information:

  • Length: 724
  • Mass: 80495
  • Checksum: 7922D3F220F9A101
  • Sequence:
    • MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY ELQVNGTEGE 
MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 762220086

Symbol: B7Z647_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z647

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 4 Gene3D 4 GeneTree 1 HGNC 1 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 4 SMART 3 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 664
  • Mass: 73872
  • Checksum: A2725F9EFE0BAD08
  • Sequence:
    • MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 517956336

Symbol: B7Z4H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4H2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 10 Gene3D 4 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 664
  • Mass: 73928
  • Checksum: 4C9E07E8A20E80DC
  • Sequence:
    • MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SVAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS RRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 2784359197

Symbol: B9EGL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9EGL1

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 4 Gene3D 4 GeneTree 1 HGNC 1 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 SMART 4 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 764
  • Mass: 85060
  • Checksum: E73F98C266EDD935
  • Sequence:
    • MSQRPRAPRS ALWLLAPPLL RWAPPLLTVL HSDLFQALLD ILDYYEASLS ESQKYRYQDE 
DTPPLEHSPA HLPNQANSPP VIVNTDTLEA PGYVNGTEGE MEYEEITLER GNSGLGFSIA 
GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV NEVDVREVTH SAAVEALKEA 
GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA 
HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY LKVAKPSNAY LSDSYAPPDI 
TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD LLGEEDIPRE PRRIVIHRGS 
TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL SVNGVDLRNA SHEQAAIALK 
NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT ASLRSNPKRG FYIRALFDYD 
KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS ETDDIGFIPS KRRVERREWS 
RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL GPTKDRANDD LLSEFPDKFG 
SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE AGQYNSHLYG TSVQSVREVA 
EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE INKRITEEQA RKAFDRATKL 
EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA RERL