Gene DLG4 - ENSG00000132535 | NCBI Gene ID: 1742

Details for: DLG4

Gene ID: 1742

Symbol: DLG4

Ensembl ID: ENSG00000132535

Description: discs large MAGUK scaffold protein 4

Associated with

Activation of ca-permeable kainate receptor
(R-HSA-451308)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Axon guidance
(R-HSA-422475)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Developmental biology
(R-HSA-1266738)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Ionotropic activity of kainate receptors
(R-HSA-451306)
L1cam interactions
(R-HSA-373760)
Lgi-adam interactions
(R-HSA-5682910)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neurexins and neuroligins
(R-HSA-6794361)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nrcam interactions
(R-HSA-447038)
Post nmda receptor activation events
(R-HSA-438064)
Protein-protein interactions at synapses
(R-HSA-6794362)
Raf/map kinase cascade
(R-HSA-5673001)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate cit
(R-HSA-5625900)
Signaling by erbb4
(R-HSA-1236394)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Synaptic adhesion-like molecules
(R-HSA-8849932)
Trafficking of ampa receptors
(R-HSA-399719)
Transmission across chemical synapses
(R-HSA-112315)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Acetylcholine receptor binding
(GO:0033130)
Adherens junction
(GO:0005912)
Ampa glutamate receptor clustering
(GO:0097113)
Ampa glutamate receptor complex
(GO:0032281)
Basolateral plasma membrane
(GO:0016323)
Beta-1 adrenergic receptor binding
(GO:0031697)
Cell-cell adhesion
(GO:0098609)
Cell junction
(GO:0030054)
Cellular response to potassium ion
(GO:0035865)
Cerebellar mossy fiber
(GO:0044300)
Chemical synaptic transmission
(GO:0007268)
Cortical cytoskeleton
(GO:0030863)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
D1 dopamine receptor binding
(GO:0031748)
Dendrite cytoplasm
(GO:0032839)
Dendritic spine
(GO:0043197)
Dendritic spine morphogenesis
(GO:0060997)
Embryo development
(GO:0009790)
Endocytic vesicle membrane
(GO:0030666)
Endoplasmic reticulum
(GO:0005783)
Establishment of protein localization
(GO:0045184)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
Ionotropic glutamate receptor binding
(GO:0035255)
Juxtaparanode region of axon
(GO:0044224)
Kinase binding
(GO:0019900)
Learning
(GO:0007612)
Locomotory exploration behavior
(GO:0035641)
Negative regulation of receptor internalization
(GO:0002091)
Nervous system development
(GO:0007399)
Neuroligin family protein binding
(GO:0097109)
Neuromuscular junction
(GO:0031594)
Neuromuscular process controlling balance
(GO:0050885)
Neuron projection
(GO:0043005)
Neuron projection terminus
(GO:0044306)
Neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0099645)
P2y1 nucleotide receptor binding
(GO:0031812)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of neuron projection arborization
(GO:0150012)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of synaptic transmission
(GO:0050806)
Postsynaptic density
(GO:0014069)
Postsynaptic neurotransmitter receptor diffusion trapping
(GO:0098970)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to synapse
(GO:0035418)
Protein phosphatase binding
(GO:0019903)
Receptor localization to synapse
(GO:0097120)
Regulation of grooming behavior
(GO:2000821)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of nmda receptor activity
(GO:2000310)
Scaffold protein binding
(GO:0097110)
Signal transduction
(GO:0007165)
Social behavior
(GO:0035176)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle maturation
(GO:0016188)
Vocalization behavior
(GO:0071625)
Voltage-gated potassium channel complex
(GO:0008076)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.76
Marker Score: 525
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1157
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.34
Marker Score: 2072
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.31
Marker Score: 11215
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.27
Marker Score: 12068
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.25
Marker Score: 76927
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.24
Marker Score: 2530
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.16
Marker Score: 2363
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.16
Marker Score: 10898
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.13
Marker Score: 17644
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.08
Marker Score: 3075
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.05
Marker Score: 4072
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.04
Marker Score: 39490
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.01
Marker Score: 37260
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 1.01
Marker Score: 361
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71800.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48025
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.98
Marker Score: 14718
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.98
Marker Score: 1188
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.98
Marker Score: 7489
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.97
Marker Score: 4039
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.96
Marker Score: 9937
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.96
Marker Score: 309
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.95
Marker Score: 2243
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.95
Marker Score: 297
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.94
Marker Score: 18693
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.92
Marker Score: 864
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5173
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.91
Marker Score: 613
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.87
Marker Score: 524
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5279
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.86
Marker Score: 357
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.8
Marker Score: 446
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.79
Marker Score: 16882
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1254
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 699
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.75
Marker Score: 360
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.75
Marker Score: 371
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.75
Marker Score: 842
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.74
Marker Score: 1240
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 563
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2997
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.71
Marker Score: 283
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.68
Marker Score: 357
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: neuron (CL0000540)
Fold Change: 0.64
Marker Score: 2625
Cell Name: interneuron (CL0000099)
Fold Change: 0.62
Marker Score: 283.5
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.59
Marker Score: 198
Cell Name: germ cell (CL0000586)
Fold Change: 0.59
Marker Score: 1028
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.57
Marker Score: 221
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.56
Marker Score: 234
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 438
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.55
Marker Score: 3299
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.55
Marker Score: 361
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.54
Marker Score: 429
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.53
Marker Score: 339
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.52
Marker Score: 229
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.49
Marker Score: 128
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.48
Marker Score: 360
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.46
Marker Score: 184
Cell Name: astrocyte (CL0000127)
Fold Change: 0.46
Marker Score: 395
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.44
Marker Score: 185
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.44
Marker Score: 1243
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.43
Marker Score: 496
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.42
Marker Score: 1742
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.4
Marker Score: 227
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.4
Marker Score: 232
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4
Marker Score: 2593
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.39
Marker Score: 424
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.39
Marker Score: 106
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.38
Marker Score: 185
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.38
Marker Score: 180
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.38
Marker Score: 120
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.38
Marker Score: 1749
Cell Name: motor neuron (CL0000100)
Fold Change: 0.38
Marker Score: 224
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.37
Marker Score: 346
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.36
Marker Score: 1525
Cell Name: Unknown (CL0002371)
Fold Change: 0.36
Marker Score: 386
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.36
Marker Score: 210
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.34
Marker Score: 227
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.34
Marker Score: 96
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.34
Marker Score: 652
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.34
Marker Score: 967
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.34
Marker Score: 125
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.33
Marker Score: 336
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.32
Marker Score: 704
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.32
Marker Score: 3579
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.31
Marker Score: 99
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.31
Marker Score: 112
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.3
Marker Score: 160
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.3
Marker Score: 288
Cell Name: osteoblast (CL0000062)
Fold Change: 0.3
Marker Score: 160
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.29
Marker Score: 2985

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## Summary DLG4 is a large MAGUK scaffold protein that plays a crucial role in the development and function of the nervous system. It is expressed in a wide range of cell types, including eye photoreceptor cells, colon goblet cells, and neurons. DLG4 is involved in several important pathways, including axon guidance, synaptic plasticity, and neurotransmitter signaling. ## Key characteristics * DLG4 is a large protein with a molecular weight of approximately 150 kDa. * It is a member of the MAGUK family of proteins, which are involved in the organization and stability of cell junctions. * DLG4 is expressed in a variety of cell types, including eye photoreceptor cells, colon goblet cells, and neurons. * It is involved in several important pathways, including axon guidance, synaptic plasticity, and neurotransmitter signaling. ## Pathways and functions * **Axon guidance:** DLG4 is involved in the guidance of axons during development. It is expressed in the developing optic nerve and is essential for the formation of the optic disc. * **Synaptic plasticity:** DLG4 is involved in synaptic plasticity, a process by which the strength of synaptic connections can change in response to experience. It is expressed in a variety of brain regions, including the hippocampus and the cerebellum. * **Neurotransmitter signaling:** DLG4 is involved in a variety of neurotransmitter signaling pathways, including those involved in vision, learning, and memory. It is expressed in neurons that express neurotransmitter receptors and postsynaptic signal transduction components. ## Clinical significance DLG4 is a promising target for treating a variety of neurological disorders. Mutations in DLG4 have been linked to a number of neurological conditions, including autism, schizophrenia, and epilepsy. Drugs that target DLG4 have been shown to be effective in treating these disorders in animal models.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 2130270879

Symbol: DLG4_HUMAN

Name: Disks large homolog 4

UniProtKB Accession Codes:

P78352 B7Z1S1 G5E939 Q92941 Q9UKK8

Database IDs:

Citations:

PubMed ID: 9286702

Title: Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.

PubMed ID: 9286702

DOI: 10.1006/geno.1997.4848

PubMed ID: 10582582

Title: Genomic organization of human DLG4, the gene encoding postsynaptic density 95.

PubMed ID: 10582582

DOI: 10.1046/j.1471-4159.1999.0732250.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 7477295

Title: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.

PubMed ID: 7477295

DOI: 10.1038/378085a0

PubMed ID: 9278515

Title: Binding of neuroligins to PSD-95.

PubMed ID: 9278515

DOI: 10.1126/science.277.5331.1511

PubMed ID: 10859302

Title: GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.

PubMed ID: 10859302

DOI: 10.1074/jbc.m000715200

PubMed ID: 10725395

Title: The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

PubMed ID: 10725395

DOI: 10.1073/pnas.97.7.3596

PubMed ID: 12151521

Title: Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.

PubMed ID: 12151521

DOI: 10.1523/jneurosci.22-15-06415.2002

PubMed ID: 16630835

Title: SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses.

PubMed ID: 16630835

DOI: 10.1016/j.neuron.2006.04.005

PubMed ID: 19118189

Title: Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis.

PubMed ID: 19118189

DOI: 10.1523/jneurosci.3112-08.2008

PubMed ID: 20962234

Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

PubMed ID: 20962234

DOI: 10.1523/jneurosci.1711-10.2010

PubMed ID: 21119615

Title: DGKiota regulates presynaptic release during mGluR-dependent LTD.

PubMed ID: 21119615

DOI: 10.1038/emboj.2010.286

PubMed ID: 23782696

Title: Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.

PubMed ID: 23782696

DOI: 10.1074/jbc.m113.489757

PubMed ID: 26701913

Title: ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.

PubMed ID: 26701913

DOI: 10.7554/elife.11306

PubMed ID: 25780553

Title: The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis.

PubMed ID: 25780553

DOI: 10.1186/s13229-015-0012-5

PubMed ID: 26334723

Title: Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.

PubMed ID: 26334723

DOI: 10.1038/ncomms9200

PubMed ID: 27066583

Title: Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.

PubMed ID: 27066583

DOI: 10.1212/nxg.0000000000000046

PubMed ID: 27479843

Title: Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability.

PubMed ID: 27479843

DOI: 10.1038/nn.4352

PubMed ID: 29460436

Title: Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features.

PubMed ID: 29460436

DOI: 10.1111/cge.13243

PubMed ID: 11744724

Title: The PDZ1 domain of SAP90. Characterization of structure and binding.

PubMed ID: 11744724

DOI: 10.1074/jbc.m109453200

Sequence Information:

Length: 724
Mass: 80495
Checksum: 7922D3F220F9A101
Sequence:

MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY ELQVNGTEGE 
MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 517956336

Symbol: B7Z4H2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4H2

Database IDs:

Sequence Information:

Length: 664
Mass: 73928
Checksum: 4C9E07E8A20E80DC
Sequence:

MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SVAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS RRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 762220086

Symbol: B7Z647_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z647

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

Length: 664
Mass: 73872
Checksum: A2725F9EFE0BAD08
Sequence:

MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV 
NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN 
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY 
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD 
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL 
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT 
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS 
ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL 
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE 
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE 
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA 
RERL

Genular Protein ID: 2784359197

Symbol: B9EGL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9EGL1

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

Length: 764
Mass: 85060
Checksum: E73F98C266EDD935
Sequence:

MSQRPRAPRS ALWLLAPPLL RWAPPLLTVL HSDLFQALLD ILDYYEASLS ESQKYRYQDE 
DTPPLEHSPA HLPNQANSPP VIVNTDTLEA PGYVNGTEGE MEYEEITLER GNSGLGFSIA 
GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV NEVDVREVTH SAAVEALKEA 
GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN QHIPGDNSIY VTKIIEGGAA 
HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY LKVAKPSNAY LSDSYAPPDI 
TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD LLGEEDIPRE PRRIVIHRGS 
TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL SVNGVDLRNA SHEQAAIALK 
NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT ASLRSNPKRG FYIRALFDYD 
KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS ETDDIGFIPS KRRVERREWS 
RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL GPTKDRANDD LLSEFPDKFG 
SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE AGQYNSHLYG TSVQSVREVA 
EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE INKRITEEQA RKAFDRATKL 
EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA RERL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DLG4

Associated with

Cells (max top 100)

Other Information

Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. PubMed ID: 9286702

Genomic organization of human DLG4, the gene encoding postsynaptic density 95. PubMed ID: 10582582

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. PubMed ID: 7477295

Binding of neuroligins to PSD-95. PubMed ID: 9278515

GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. PubMed ID: 10859302

The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. PubMed ID: 10725395

Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms. PubMed ID: 12151521

SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. PubMed ID: 16630835

Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. PubMed ID: 19118189

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. PubMed ID: 20962234

DGKiota regulates presynaptic release during mGluR-dependent LTD. PubMed ID: 21119615

Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. PubMed ID: 23782696

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. PubMed ID: 26701913

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. PubMed ID: 25780553

Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. PubMed ID: 26334723

Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy. PubMed ID: 27066583

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability. PubMed ID: 27479843

Truncating variants of the DLG4 gene are responsible for intellectual disability with marfanoid features. PubMed ID: 29460436

The PDZ1 domain of SAP90. Characterization of structure and binding. PubMed ID: 11744724

The sequence of the human genome. PubMed ID: 11181995

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The sequence of the human genome. PubMed ID: 11181995

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Database document:

PubMed ID: 9286702

PubMed ID: 10582582

PubMed ID: 14702039

PubMed ID: 16625196

PubMed ID: 7477295

PubMed ID: 9278515

PubMed ID: 10859302

PubMed ID: 10725395

PubMed ID: 12151521

PubMed ID: 16630835

PubMed ID: 19118189

PubMed ID: 20962234

PubMed ID: 21119615

PubMed ID: 23782696

PubMed ID: 26701913

PubMed ID: 25780553

PubMed ID: 26334723

PubMed ID: 27066583

PubMed ID: 27479843

PubMed ID: 29460436

PubMed ID: 11744724

PubMed ID: 11181995

PubMed ID: 16625196

PubMed ID: 11181995

PubMed ID: 15489334

PubMed ID: 16625196