Details for: DNMT3B

Gene ID: 1789

Symbol: DNMT3B

Ensembl ID: ENSG00000088305

Description: DNA methyltransferase 3 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.12
    Marker Score: 815
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5295
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.93
    Marker Score: 2184
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 622.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11701
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.74
    Marker Score: 337
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.74
    Marker Score: 3018
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 563
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1374
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2997
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.62
    Marker Score: 9291
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.62
    Marker Score: 1253
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.59
    Marker Score: 213
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.59
    Marker Score: 4548
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 344
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.52
    Marker Score: 520
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 369
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 294
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.47
    Marker Score: 232
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17684
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.46
    Marker Score: 16802
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.45
    Marker Score: 119
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.44
    Marker Score: 1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.41
    Marker Score: 592
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.4
    Marker Score: 226
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 691
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.39
    Marker Score: 137
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.37
    Marker Score: 7387.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.34
    Marker Score: 162
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.32
    Marker Score: 78
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.32
    Marker Score: 183
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.31
    Marker Score: 2893
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3
    Marker Score: 117
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.29
    Marker Score: 151
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.28
    Marker Score: 205
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 270
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.28
    Marker Score: 117
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.28
    Marker Score: 172
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 115
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.27
    Marker Score: 323
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.25
    Marker Score: 1049
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.25
    Marker Score: 15214
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.24
    Marker Score: 1417
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.24
    Marker Score: 672
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.23
    Marker Score: 956
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.23
    Marker Score: 331.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.23
    Marker Score: 7903.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.23
    Marker Score: 63
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.23
    Marker Score: 620
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.23
    Marker Score: 4844
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.22
    Marker Score: 1897
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.21
    Marker Score: 58
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.21
    Marker Score: 195
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.2
    Marker Score: 191
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.2
    Marker Score: 936
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.2
    Marker Score: 81
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2
    Marker Score: 126
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 111
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.19
    Marker Score: 132.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.19
    Marker Score: 756
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.19
    Marker Score: 205
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.19
    Marker Score: 92
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 126
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.19
    Marker Score: 318
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 155
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.18
    Marker Score: 1816
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.17
    Marker Score: 178

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Other Information

**Key characteristics:** - It is a highly conserved protein with a conserved catalytic domain. - It is a member of the DNA methyltransferase family, which also includes DNMT3A and DNMT3C. - It is a nuclear protein that is primarily localized to the nucleus. **Pathways and functions:** - DNMT3B is involved in DNA methylation, which is a process that adds a methyl group to the cytosine base of DNA. - It is involved in the regulation of gene expression by methylation of DNA sequences known as CpG islands. - It is involved in the regulation of cell cycle progression and apoptosis (programmed cell death). - It is involved in the regulation of stem cell differentiation and tissue development. **Clinical significance:** - Mutations in DNMT3B have been linked to various human diseases, including colorectal cancer, lung cancer, and leukemia. - Inhibition of DNMT3B has been shown to inhibit tumor growth and metastasis in cancer cells. - Therefore, DNMT3B is a potential target for cancer therapy. **Additional notes:** - DNMT3B is a highly dynamic protein that undergoes post-translational modifications, including sumoylation and acetylation. - It is also involved in the regulation of gene expression through interactions with other proteins. - It is a key regulatory protein that plays a critical role in maintaining genomic stability and cellular homeostasis.

Genular Protein ID: 3153186204

Symbol: DNM3B_HUMAN

Name: DNA (cytosine-5)-methyltransferase 3B

UniProtKB Accession Codes:

Q9UBC3 A2A2E2 B4DSM8 B4DSU1 E1P5M6 E1P5M7 E7EN63 E9PBF2 Q9UBD4 Q9UJQ5 Q9UKA6 Q9UNE5 Q9Y5R9 Q9Y5S0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CORUM 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 15 EMDB 1 EPD 1 Ensembl 6 EvolutionaryTrace 1 GO 13 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 39 PDBsum 31 PRO 1 PROSITE 4 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 REBASE 1 RNAct 1 Reactome 5 RefSeq 6 Rhea 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10433969

Title: Cloning, expression and chromosome locations of the human DNMT3 gene family.

PubMed ID: 10433969

DOI: 10.1016/s0378-1119(99)00252-8

PubMed ID: 10647011

Title: Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.

PubMed ID: 10647011

DOI: 10.1038/46052

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 10325416

Title: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

PubMed ID: 10325416

DOI: 10.1093/nar/27.11.2291

PubMed ID: 11735126

Title: Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1.

PubMed ID: 11735126

DOI: 10.1006/bbrc.2001.6057

PubMed ID: 12145218

Title: Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases.

PubMed ID: 12145218

DOI: 10.1093/emboj/cdf401

PubMed ID: 16682412

Title: The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.

PubMed ID: 16682412

DOI: 10.1074/jbc.m513249200

PubMed ID: 16357870

Title: The Polycomb group protein EZH2 directly controls DNA methylation.

PubMed ID: 16357870

DOI: 10.1038/nature04431

PubMed ID: 17303076

Title: Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression.

PubMed ID: 17303076

DOI: 10.1016/j.bbrc.2007.01.187

PubMed ID: 17200670

Title: Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.

PubMed ID: 17200670

DOI: 10.1038/ng1950

PubMed ID: 18413740

Title: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.

PubMed ID: 18413740

DOI: 10.1158/0008-5472.can-07-6654

PubMed ID: 18567530

Title: DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription.

PubMed ID: 18567530

DOI: 10.1016/j.biocel.2008.04.018

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21720545

Title: Structural and histone binding ability characterizations of human PWWP domains.

PubMed ID: 21720545

DOI: 10.1371/journal.pone.0018919

PubMed ID: 10555141

Title: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

PubMed ID: 10555141

DOI: 10.1016/s0092-8674(00)81656-6

PubMed ID: 10588719

Title: The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.

PubMed ID: 10588719

DOI: 10.1073/pnas.96.25.14412

PubMed ID: 11102980

Title: Genetic variation in ICF syndrome: evidence for genetic heterogeneity.

PubMed ID: 11102980

DOI: 10.1002/1098-1004(200012)16:6<509::aid-humu8>3.0.co;2-v

PubMed ID: 15580563

Title: DNMT3B mutations and DNA methylation defect define two types of ICF syndrome.

PubMed ID: 15580563

DOI: 10.1002/humu.20113

PubMed ID: 21120685

Title: ICF syndrome in Saudi Arabia: immunological, cytogenetic and molecular analysis.

PubMed ID: 21120685

DOI: 10.1007/s10875-010-9488-0

PubMed ID: 27153398

Title: Mutations in DNMT3B modify epigenetic repression of the D4Z4 repeat and the penetrance of facioscapulohumeral dystrophy.

PubMed ID: 27153398

DOI: 10.1016/j.ajhg.2016.03.013

PubMed ID: 27734333

Title: A novel mutation in a critical region for the methyl donor binding in DNMT3B causes immunodeficiency, centromeric instability, and facial anomalies syndrome (ICF).

PubMed ID: 27734333

DOI: 10.1007/s10875-016-0340-z

Sequence Information:

  • Length: 853
  • Mass: 95751
  • Checksum: F20A67CF78951532
  • Sequence:
    • MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV 
SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS 
PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT 
PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP 
AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK 
AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS 
KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR GDEDQSREQM 
ASDVANNKSS LEDGCLSCGR KNPVSFHPLF EGGLCQTCRD RFLELFYMYD DDGYQSYCTV 
CCEGRELLLC SNTSCCRCFC VECLEVLVGT GTAAEAKLQE PWSCYMCLPQ RCHGVLRRRK 
DWNVRLQAFF TSDTGLEYEA PKLYPAIPAA RRRPIRVLSL FDGIATGYLV LKELGIKVGK 
YVASEVCEES IAVGTVKHEG NIKYVNDVRN ITKKNIEEWG PFDLVIGGSP CNDLSNVNPA 
RKGLYEGTGR LFFEFYHLLN YSRPKEGDDR PFFWMFENVV AMKVGDKRDI SRFLECNPVM 
IDAIKVSAAH RARYFWGNLP GMNRPVIASK NDKLELQDCL EYNRIAKLKK VQTITTKSNS 
IKQGKNQLFP VVMNGKEDVL WCTELERIFG FPVHYTDVSN MGRGARQKLL GRSWSVPVIR 
HLFAPLKDYF ACE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.