Details for: FDPSP5

Gene ID: 2229

Symbol: FDPSP5

Ensembl ID: ENSG00000215035

Description: farnesyl diphosphate synthase pseudogene 5

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1033
    Cell Significance Index: 1.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0901
    Cell Significance Index: 1.3300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.0768
    Cell Significance Index: 0.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0573
    Cell Significance Index: 1.4300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0366
    Cell Significance Index: 0.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0130
    Cell Significance Index: 0.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0109
    Cell Significance Index: 0.3200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0093
    Cell Significance Index: 0.0900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0072
    Cell Significance Index: 0.0800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0067
    Cell Significance Index: 0.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0047
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0031
    Cell Significance Index: 0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0059
    Cell Significance Index: -0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0061
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0091
    Cell Significance Index: -0.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0093
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0093
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0096
    Cell Significance Index: -0.1900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0103
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0110
    Cell Significance Index: -0.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0118
    Cell Significance Index: -0.2000
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0146
    Cell Significance Index: -0.1800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0228
    Cell Significance Index: -0.5000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0230
    Cell Significance Index: -0.2600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0248
    Cell Significance Index: -0.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0253
    Cell Significance Index: -0.2000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0259
    Cell Significance Index: -0.3100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0279
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0293
    Cell Significance Index: -0.3600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0297
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0302
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0333
    Cell Significance Index: -0.3700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0355
    Cell Significance Index: -0.4300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0374
    Cell Significance Index: -0.2000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0378
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0400
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0408
    Cell Significance Index: -0.5600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0420
    Cell Significance Index: -0.5000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0425
    Cell Significance Index: -0.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0434
    Cell Significance Index: -0.6600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0438
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0457
    Cell Significance Index: -0.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0468
    Cell Significance Index: -0.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0470
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0488
    Cell Significance Index: -0.5800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0489
    Cell Significance Index: -0.6100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0494
    Cell Significance Index: -0.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0497
    Cell Significance Index: -0.6600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0498
    Cell Significance Index: -0.6500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0502
    Cell Significance Index: -0.6600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0507
    Cell Significance Index: -0.5800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0508
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0518
    Cell Significance Index: -0.5600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0543
    Cell Significance Index: -0.6600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0545
    Cell Significance Index: -0.6200
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0546
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0549
    Cell Significance Index: -0.6100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0551
    Cell Significance Index: -0.6500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0552
    Cell Significance Index: -0.6500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0581
    Cell Significance Index: -0.6500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0585
    Cell Significance Index: -0.6500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0599
    Cell Significance Index: -0.6200
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0604
    Cell Significance Index: -0.6500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0605
    Cell Significance Index: -0.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0617
    Cell Significance Index: -0.6300
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0618
    Cell Significance Index: -0.6600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0653
    Cell Significance Index: -0.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0663
    Cell Significance Index: -0.7800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0692
    Cell Significance Index: -0.4500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0699
    Cell Significance Index: -0.8500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0709
    Cell Significance Index: -0.6600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0719
    Cell Significance Index: -0.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0719
    Cell Significance Index: -0.9400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0719
    Cell Significance Index: -0.6800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0725
    Cell Significance Index: -0.4300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0727
    Cell Significance Index: -0.6400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0755
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0852
    Cell Significance Index: -0.7900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0860
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1028
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic nature**: FDPSP5 is a non-functional pseudogene, meaning it lacks the ability to produce a protein product. However, its presence and expression patterns suggest that it may still influence gene regulation and cellular processes. 2. **Widespread expression**: FDPSP5 is significantly expressed in various cell types, including plasma cells, epithelial cells, hematopoietic stem cells, and mesenchymal stem cells. 3. **Conserved sequence**: The FDPSP5 gene exhibits high sequence conservation across different species, indicating its evolutionary significance and potential functional importance. **Pathways and Functions:** 1. **Immune regulation**: FDPSP5 has been implicated in the regulation of immune responses, particularly in the context of plasma cell differentiation and function. Its expression in plasma cells suggests a role in modulating antibody production and immune homeostasis. 2. **Cell differentiation**: FDPSP5 may influence cell differentiation processes, including the development of epithelial and hematopoietic stem cells. Its expression in these cell types suggests a role in regulating cellular fate and specialization. 3. **Tissue homeostasis**: FDPSP5 may contribute to tissue homeostasis by regulating the balance between cell proliferation, differentiation, and survival in various tissues, including the mammary gland and retina. **Clinical Significance:** 1. **Immunological disorders**: Dysregulation of FDPSP5 expression has been linked to various immunological disorders, including autoimmune diseases and cancer. Further research is needed to elucidate the specific mechanisms underlying these associations. 2. **Cancer biology**: FDPSP5 has been implicated in cancer biology, particularly in the context of epithelial-to-mesenchymal transition (EMT) and tumor progression. Its expression in cancer cells suggests a potential role in promoting metastasis and tumor growth. 3. **Stem cell biology**: FDPSP5 may influence stem cell biology, particularly in the context of hematopoietic stem cell development and maintenance. Its expression in hematopoietic stem cells suggests a role in regulating cellular proliferation and differentiation. In conclusion, the FDPSP5 gene, despite its pseudogenic nature, has emerged as a key player in various biological processes, including immune regulation, cell differentiation, and tissue homeostasis. Further research is needed to fully elucidate the mechanisms underlying FDPSP5 function and its clinical significance, but its implications for immunological disorders, cancer biology, and stem cell biology are significant and warrant further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.