Details for: GAS8

Gene ID: 2622

Symbol: GAS8

Ensembl ID: ENSG00000141013

Description: growth arrest specific 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.45
    Marker Score: 1100
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.62
    Marker Score: 678
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.57
    Marker Score: 499
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.56
    Marker Score: 13549
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.52
    Marker Score: 5216
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.5
    Marker Score: 6103
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50324
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.35
    Marker Score: 83221
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.27
    Marker Score: 1962
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.25
    Marker Score: 12934
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.24
    Marker Score: 340
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.18
    Marker Score: 10128
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.17
    Marker Score: 11108
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.08
    Marker Score: 4483
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.07
    Marker Score: 21271.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.07
    Marker Score: 40451.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.05
    Marker Score: 4071
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.05
    Marker Score: 1999
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.01
    Marker Score: 9536
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.97
    Marker Score: 445
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.97
    Marker Score: 5869
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.96
    Marker Score: 562
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.94
    Marker Score: 7233.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.94
    Marker Score: 550
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.89
    Marker Score: 13276
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.85
    Marker Score: 885
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1283.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.78
    Marker Score: 248
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.76
    Marker Score: 16236
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.75
    Marker Score: 358
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11698
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3070
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 557
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1212
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.67
    Marker Score: 3952
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.64
    Marker Score: 14288
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.64
    Marker Score: 684.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 541
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.62
    Marker Score: 2586
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.6
    Marker Score: 608
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 317
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.57
    Marker Score: 1212
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.56
    Marker Score: 19475
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.56
    Marker Score: 432
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.55
    Marker Score: 1964
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1096
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.52
    Marker Score: 9198
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.5
    Marker Score: 539
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.48
    Marker Score: 1101
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.48
    Marker Score: 322
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.48
    Marker Score: 471
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.47
    Marker Score: 563
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.45
    Marker Score: 173
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.45
    Marker Score: 359
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.45
    Marker Score: 15113
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.45
    Marker Score: 1722
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.44
    Marker Score: 465
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.44
    Marker Score: 646
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.44
    Marker Score: 2014
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.43
    Marker Score: 126
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.43
    Marker Score: 1155
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.43
    Marker Score: 577.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.43
    Marker Score: 249
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.43
    Marker Score: 160
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.42
    Marker Score: 750
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.42
    Marker Score: 190
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.42
    Marker Score: 151
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.41
    Marker Score: 2490
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.41
    Marker Score: 591
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.41
    Marker Score: 138
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.39
    Marker Score: 264
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.39
    Marker Score: 291
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.39
    Marker Score: 810
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.39
    Marker Score: 335
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.39
    Marker Score: 128
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.39
    Marker Score: 977
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.39
    Marker Score: 254
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.39
    Marker Score: 115
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.39
    Marker Score: 293
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.38
    Marker Score: 420
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.38
    Marker Score: 1395
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.38
    Marker Score: 453
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.38
    Marker Score: 88
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 196
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.37
    Marker Score: 5930
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.37
    Marker Score: 205
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 239
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.36
    Marker Score: 148
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.36
    Marker Score: 1267
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.35
    Marker Score: 408
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 368

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Other Information

## Summary The GAS8 gene encodes a protein involved in the regulation of cell movement and cell population proliferation. It is significantly expressed in various cell types, including epithelial cells of the lung, retinal ganglion cells, and neurons. ## Key characteristics * The protein is a member of the growth arrest-specific family of proteins (GASs). * GASs are known to regulate cell cycle progression and cell migration by interacting with the cytoskeleton. * The GAS8 protein is expressed in a variety of cell types, suggesting that it plays a role in maintaining cellular homeostasis and preventing cancer. ## Pathways and functions * The GAS8 protein is involved in the activation of the small GTPase Ras, which is a key regulator of cell growth and proliferation. * GAS8 also regulates the assembly of the axoneme, a microtubule-based structure that is involved in cell migration. * The protein also plays a role in the regulation of cilium movement, which is important for cell migration and tissue development. * In addition to its role in cell movement, GAS8 has also been shown to play a role in the regulation of epithelial cell migration and the development of the neural tube. ## Clinical significance The GAS8 gene has been linked to a number of human diseases, including lung cancer, retinal diseases, and neurodegenerative disorders. Mutations in the GAS8 gene have been shown to be associated with these diseases, suggesting that the protein plays a role in the development and progression of these conditions. ## Additional notes * The GAS8 gene is highly expressed in the developing nervous system, suggesting that it plays a role in the early development of the brain and spinal cord. * The protein is also expressed in the lung, where it is involved in the regulation of epithelial cell migration and tumor growth. * The GAS8 gene is a promising target for the development of new cancer therapies.

Genular Protein ID: 3194924535

Symbol: DRC4_HUMAN

Name: Growth arrest-specific protein 11

UniProtKB Accession Codes:

O95995 B2RCT1 B7Z4U1 G3V1L5 Q2M234

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 19 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 24 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9790751

Title: Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer.

PubMed ID: 9790751

DOI: 10.1006/geno.1998.5457

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10969087

Title: T lymphocyte-triggering factor of African trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes.

PubMed ID: 10969087

DOI: 10.1074/jbc.m006907200

PubMed ID: 16643277

Title: Expanding the role of the dynein regulatory complex to non-axonemal functions: association of GAS11 with the Golgi apparatus.

PubMed ID: 16643277

DOI: 10.1111/j.1600-0854.2006.00411.x

PubMed ID: 21659505

Title: Growth arrest specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.

PubMed ID: 21659505

DOI: 10.1074/jbc.m111.234666

PubMed ID: 26387594

Title: Loss-of-function GAS8 mutations cause primary ciliary dyskinesia and disrupt the nexin-dynein regulatory complex.

PubMed ID: 26387594

DOI: 10.1016/j.ajhg.2015.08.012

PubMed ID: 34169321

Title: Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse.

PubMed ID: 34169321

DOI: 10.1093/hmg/ddab171

PubMed ID: 27120127

Title: Mutations in GAS8, a gene encoding a nexin-dynein regulatory complex subunit, cause primary ciliary dyskinesia with axonemal disorganization.

PubMed ID: 27120127

DOI: 10.1002/humu.23005

PubMed ID: 27472056

Title: Mutation of growth arrest specific 8 reveals a role in motile cilia function and human disease.

PubMed ID: 27472056

DOI: 10.1371/journal.pgen.1006220

Sequence Information:

  • Length: 478
  • Mass: 56356
  • Checksum: 2EDBC7981868EB12
  • Sequence:
    • MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH 
TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG 
TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER 
QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI 
TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY 
ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT 
GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL 
QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT

Genular Protein ID: 206357965

Symbol: B7Z1U9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1U9

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 6 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1

Sequence Information:

  • Length: 395
  • Mass: 46363
  • Checksum: 503C9B71DA310DAA
  • Sequence:
    • MEEAEERHQV EIKVYKQKVK HLLYEHQNNL TEMKAEGTVV MKLAQKEHRI QESVLRKDMR 
ALKVELKEQE LASEVVVKNL RLKHTEEITR MRNDFERQVR EIEAKYDKKM KMLRDELDLR 
RKTELHEVEE RKNGQIHTLM QRHEEAFTDI KNYYNDITLN NLALINPLKE QMEDMRKKED 
HLEREMAEVS GQNKRLADPL QKAREEMSEM QKQLANYERD KQILLCTKAR LKVREKELKD 
LQWEHEVLEQ RFTKVQQERD ELYRKFTAAI QEVQQKTGFK NLVLERKLQA LSAAVEKKEV 
QFNEVLAASN LDPAALTLVS RKLEDVLESK NSTIKDLQYE LAQVCKAHND LLRTYEAKLL 
AFGIPLDNVG FKPLETAVIG QTLGQGPAGL VGTPT

Genular Protein ID: 2193149837

Symbol: A0A087WZT7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZT7

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 7 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 395
  • Mass: 46353
  • Checksum: E761EEA687F22E67
  • Sequence:
    • MEEAEERHQV EIKVYKQKVK HLLYEHQNNL TEMKAEGTVV MKLAQKEHRI QESVLRKDMR 
ALKVELKEQE LASEVVVKNL RLKHTEEITR MRNDFERQVR EIEAKYDKKM KMLRDELDLR 
RKTELHEVEE RKNGQIHTLM QRHEEAFTDI KNYYNDITLN NLALINSLKE QMEDMRKKED 
HLEREMAEVS GQNKRLADPL QKAREEMSEM QKQLANYERD KQILLCTKAR LKVREKELKD 
LQWEHEVLEQ RFTKVQQERD ELYRKFTAAI QEVQQKTGFK NLVLERKLQA LSAAVEKKEV 
QFNEVLAASN LDPAALTLVS RKLEDVLESK NSTIKDLQYE LAQVCKAHND LLRTYEAKLL 
AFGIPLDNVG FKPLETAVIG QTLGQGPAGL VGTPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.