Details for: OR5H1

Gene ID: 26341

Symbol: OR5H1

Ensembl ID: ENSG00000231192

Description: olfactory receptor family 5 subfamily H member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2717
    Cell Significance Index: 3.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1091
    Cell Significance Index: 5.6700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0925
    Cell Significance Index: 1.0800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0480
    Cell Significance Index: 0.6700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0135
    Cell Significance Index: 0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0082
    Cell Significance Index: 0.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0031
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0028
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0041
    Cell Significance Index: -0.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0137
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0145
    Cell Significance Index: -0.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0161
    Cell Significance Index: -0.4100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0182
    Cell Significance Index: -0.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0199
    Cell Significance Index: -0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0240
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0271
    Cell Significance Index: -0.5400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0278
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0294
    Cell Significance Index: -0.3100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0311
    Cell Significance Index: -0.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0315
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0326
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0337
    Cell Significance Index: -0.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0352
    Cell Significance Index: -0.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0354
    Cell Significance Index: -0.7100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0360
    Cell Significance Index: -0.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0364
    Cell Significance Index: -0.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0377
    Cell Significance Index: -0.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0411
    Cell Significance Index: -0.7100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0428
    Cell Significance Index: -0.5600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0429
    Cell Significance Index: -0.5700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0466
    Cell Significance Index: -0.4600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0469
    Cell Significance Index: -0.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0477
    Cell Significance Index: -0.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0478
    Cell Significance Index: -0.5500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0489
    Cell Significance Index: -0.5900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0496
    Cell Significance Index: -0.5100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0526
    Cell Significance Index: -0.6400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0531
    Cell Significance Index: -0.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0544
    Cell Significance Index: -0.7100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0552
    Cell Significance Index: -0.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0553
    Cell Significance Index: -0.6500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0554
    Cell Significance Index: -0.7000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0561
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0572
    Cell Significance Index: -0.7400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0576
    Cell Significance Index: -0.6800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0578
    Cell Significance Index: -0.6700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0582
    Cell Significance Index: -0.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0587
    Cell Significance Index: -0.7000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0590
    Cell Significance Index: -0.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0591
    Cell Significance Index: -0.6000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0591
    Cell Significance Index: -0.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0596
    Cell Significance Index: -0.6600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0597
    Cell Significance Index: -0.7100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0597
    Cell Significance Index: -0.7100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0617
    Cell Significance Index: -0.6400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0618
    Cell Significance Index: -0.6100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0619
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0627
    Cell Significance Index: -0.6500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0627
    Cell Significance Index: -0.5300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0631
    Cell Significance Index: -0.6300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0636
    Cell Significance Index: -0.6700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0643
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0643
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0645
    Cell Significance Index: -0.6400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0656
    Cell Significance Index: -0.6700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0658
    Cell Significance Index: -0.8500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0659
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0659
    Cell Significance Index: -0.8100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0664
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0666
    Cell Significance Index: -0.6400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0667
    Cell Significance Index: -0.7100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0674
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0677
    Cell Significance Index: -0.9300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0686
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0686
    Cell Significance Index: -0.6500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0694
    Cell Significance Index: -0.6100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0695
    Cell Significance Index: -0.8800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0696
    Cell Significance Index: -0.8700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0701
    Cell Significance Index: -0.7300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0704
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0704
    Cell Significance Index: -0.8500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0705
    Cell Significance Index: -0.7100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0707
    Cell Significance Index: -0.9100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0710
    Cell Significance Index: -0.8500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0714
    Cell Significance Index: -0.6600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0714
    Cell Significance Index: -0.9200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0715
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0716
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0721
    Cell Significance Index: -0.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR5H1 is an olfactory receptor that binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor Activity:** OR5H1 belongs to the G protein-coupled receptor family, which is characterized by its ability to activate G proteins, leading to various downstream signaling pathways. 3. **Expression in Multiple Cell Types:** OR5H1 is expressed in a wide range of cell types, including goblet cells, intestinal epithelial cells, pericytes, and others, highlighting its diverse roles in the body. 4. **Signaling Pathway:** OR5H1 activates the G protein-coupled receptor signaling pathway, which involves the activation of G proteins, subsequent signaling cascades, and ultimately, the perception of smell. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR5H1 plays a crucial role in detecting chemical stimuli involved in sensory perception of smell, allowing us to perceive and differentiate between various odors. 2. **Expression and Translocation of Olfactory Receptors:** OR5H1 is involved in the expression and translocation of olfactory receptors, ensuring that the correct olfactory receptors are expressed in the right cells to detect specific odorants. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR5H1 activates the G protein-coupled receptor signaling pathway, which is essential for the transduction of olfactory signals and the perception of smell. 4. **Olfactory Signaling Pathway:** OR5H1 is part of the olfactory signaling pathway, which involves the coordination of multiple signaling components to ultimately lead to the perception of smell. **Clinical Significance:** 1. **Olfactory Dysfunction:** OR5H1 mutations have been associated with olfactory dysfunction, a condition characterized by a reduced ability to perceive smells. 2. **Neurological Disorders:** OR5H1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, where olfactory dysfunction is a common symptom. 3. **Cancer Research:** OR5H1 has been identified as a potential biomarker for cancer, particularly in the context of intestinal cancer, where it is expressed in cancer cells and has been associated with poor prognosis. 4. **Pharmacological Applications:** OR5H1 has been targeted by pharmaceutical companies as a potential therapeutic target for the treatment of olfactory dysfunction and other neurological disorders. In conclusion, OR5H1 is a crucial gene that plays a pivotal role in the detection of chemical stimuli involved in sensory perception of smell. Its diverse roles in the body, including its expression in multiple cell types and involvement in various signaling pathways, highlight its importance in maintaining normal olfactory function. Further research on OR5H1 is necessary to fully understand its clinical significance and potential therapeutic applications.

Genular Protein ID: 1501560609

Symbol: OR5H1_HUMAN

Name: Olfactory receptor 5H1

UniProtKB Accession Codes:

A6NKK0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 1370859

Title: Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

PubMed ID: 1370859

DOI: 10.1038/355453a0

Sequence Information:

  • Length: 313
  • Mass: 35387
  • Checksum: ABF576A58DF9BFF0
  • Sequence:
    • MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY 
LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSFAISVTT ECFLLATMAY 
DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGILHALIHE GFLFRLTFCN SNIVHHIYCD 
TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST 
CGAHLFSVSL YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS 
FTKMLKKHVK VSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.