Details for: OR4E1

Gene ID: 26687

Symbol: OR4E1

Ensembl ID: ENSG00000276240

Description: olfactory receptor family 4 subfamily E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0505
    Cell Significance Index: 0.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0459
    Cell Significance Index: 0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0287
    Cell Significance Index: 1.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0208
    Cell Significance Index: 0.3900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0196
    Cell Significance Index: 0.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0082
    Cell Significance Index: 0.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0071
    Cell Significance Index: 0.0800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0045
    Cell Significance Index: 0.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0026
    Cell Significance Index: 0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0020
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0024
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0104
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0141
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0152
    Cell Significance Index: -0.1600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0183
    Cell Significance Index: -0.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0187
    Cell Significance Index: -0.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0189
    Cell Significance Index: -0.2400
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0201
    Cell Significance Index: -0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0218
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0226
    Cell Significance Index: -0.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0235
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0240
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0255
    Cell Significance Index: -0.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0261
    Cell Significance Index: -0.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0264
    Cell Significance Index: -0.5300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0268
    Cell Significance Index: -0.2900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0282
    Cell Significance Index: -0.1800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0290
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0307
    Cell Significance Index: -0.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0317
    Cell Significance Index: -0.2100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0319
    Cell Significance Index: -0.4200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0327
    Cell Significance Index: -0.5300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0338
    Cell Significance Index: -0.3600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0344
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0350
    Cell Significance Index: -0.4800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0377
    Cell Significance Index: -0.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0380
    Cell Significance Index: -0.4800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0381
    Cell Significance Index: -0.5000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0389
    Cell Significance Index: -0.4000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0399
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0403
    Cell Significance Index: -0.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0411
    Cell Significance Index: -0.5700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0414
    Cell Significance Index: -0.3700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0417
    Cell Significance Index: -0.4900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0424
    Cell Significance Index: -0.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0434
    Cell Significance Index: -0.4800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0437
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0442
    Cell Significance Index: -0.4700
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0456
    Cell Significance Index: -0.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0457
    Cell Significance Index: -0.5300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0463
    Cell Significance Index: -0.5300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0464
    Cell Significance Index: -0.5700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0465
    Cell Significance Index: -0.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0474
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0479
    Cell Significance Index: -0.4500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0479
    Cell Significance Index: -0.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0480
    Cell Significance Index: -0.4900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0480
    Cell Significance Index: -0.5700
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0481
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0484
    Cell Significance Index: -0.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0487
    Cell Significance Index: -0.5800
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0488
    Cell Significance Index: -0.5600
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0493
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0494
    Cell Significance Index: -0.5300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0497
    Cell Significance Index: -0.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0500
    Cell Significance Index: -0.3100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0503
    Cell Significance Index: -0.4400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0505
    Cell Significance Index: -0.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0516
    Cell Significance Index: -0.5200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0517
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0521
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0529
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0530
    Cell Significance Index: -0.5400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0534
    Cell Significance Index: -0.5800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0535
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genomic Location:** The OR4E1 gene is located on chromosome 2q33.3 in humans (ENSG00000276240). 2. **Expression Patterns:** OR4E1 is significantly expressed in immune cells, including B cells, natural killer cells, dendritic cells, monocytes, and macrophages. 3. **Receptor Type:** OR4E1 is a G protein-coupled receptor, which is a class of receptors that respond to ligand binding by activating G proteins and initiating downstream signaling pathways. 4. **Ligand Binding:** OR4E1 binds to odorant molecules, which are small molecules that elicit a specific response from the olfactory system. **Pathways and Functions:** 1. **Detection of Chemical Stimulus:** OR4E1 plays a crucial role in detecting chemical stimuli involved in the sensory perception of smell. When an odorant molecule binds to OR4E1, it activates a signaling cascade that ultimately leads to the perception of the odor. 2. **G Protein-Coupled Receptor Signaling:** OR4E1 is a member of the G protein-coupled receptor family, which responds to ligand binding by activating G proteins. This activation leads to the activation of downstream signaling pathways, including the activation of adenylate cyclase and the production of cAMP. 3. **Olfactory Signaling Pathway:** OR4E1 is part of the olfactory signaling pathway, which is responsible for the transmission of olfactory information from the nose to the brain. 4. **Immune Regulation:** OR4E1 is also expressed in immune cells, suggesting its involvement in immune regulation and potentially in the regulation of the olfactory system. **Clinical Significance:** 1. **Olfactory Disorders:** Mutations in the OR4E1 gene have been associated with olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Immune Regulation:** OR4E1 may play a role in regulating immune responses, particularly in the context of inflammation and infection. 3. **Neurological Disorders:** OR4E1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cancer:** OR4E1 has been identified as a potential biomarker for cancer, particularly in the context of epithelial cancers. In conclusion, OR4E1 is a critical gene involved in the detection of chemical stimuli involved in the sensory perception of smell. Its expression in immune cells suggests its involvement in immune regulation and potentially in the regulation of the olfactory system. Further research is needed to fully elucidate the role of OR4E1 in human health and disease.

Genular Protein ID: 894561641

Symbol: OR4E1_HUMAN

Name: Olfactory receptor 4E1

UniProtKB Accession Codes:

P0C645 A0A126GWU0

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

PubMed ID: 17973576

Title: Genetic elucidation of human hyperosmia to isovaleric acid.

PubMed ID: 17973576

DOI: 10.1371/journal.pbio.0050284

Sequence Information:

  • Length: 315
  • Mass: 35737
  • Checksum: E5068A662A804A21
  • Sequence:
    • MEEAILLNQT SLVTYFRLRG LSVNHKARIA MFSMFLIFYV LTLIGNVLIV ITIIYDHRLH 
TPMYFFLSNL SFIDVCHSTV TVPKMLRDVW SEEKLISFDA CVTQMFFLHL FACTEIFLLT 
VMAYDRYVAI CKPLQYMIVM NWKVCVLLAV ALWTGGTIHS IALTSLTIKL PYCGPDEIDN 
FFCDVPQVIK LACIDTHVIE ILIVSNSGLI SVVCFVVLVV SYAVILVSLR QQISKGKRKA 
LSTCAAHLTV VTLFLGHCIF IYSRPSTSLP EDKVVSVFFT AVTPLLNPII YTLRNEEMKS 
ALNKLVGRKE RKEEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.