Details for: SNORA66

Gene ID: 26782

Symbol: SNORA66

Ensembl ID: ENSG00000207523

Description: small nucleolar RNA, H/ACA box 66

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.8749
    Cell Significance Index: -1.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3861
    Cell Significance Index: 5.5000
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1626
    Cell Significance Index: 1.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0767
    Cell Significance Index: 2.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0718
    Cell Significance Index: 3.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0469
    Cell Significance Index: 0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0437
    Cell Significance Index: 7.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0082
    Cell Significance Index: 0.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0016
    Cell Significance Index: 0.1000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0188
    Cell Significance Index: -0.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0292
    Cell Significance Index: -1.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0384
    Cell Significance Index: -1.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0448
    Cell Significance Index: -0.9700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0552
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0568
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0665
    Cell Significance Index: -1.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0666
    Cell Significance Index: -2.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0816
    Cell Significance Index: -2.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0899
    Cell Significance Index: -1.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0942
    Cell Significance Index: -2.4000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1151
    Cell Significance Index: -1.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1160
    Cell Significance Index: -1.7400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1179
    Cell Significance Index: -1.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1205
    Cell Significance Index: -1.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1228
    Cell Significance Index: -1.6100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1270
    Cell Significance Index: -1.3400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1403
    Cell Significance Index: -1.5400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1405
    Cell Significance Index: -1.6700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1411
    Cell Significance Index: -1.5800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1437
    Cell Significance Index: -1.8000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1440
    Cell Significance Index: -1.4900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1462
    Cell Significance Index: -1.8300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1476
    Cell Significance Index: -1.7800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1478
    Cell Significance Index: -1.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1493
    Cell Significance Index: -1.7800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1500
    Cell Significance Index: -2.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1527
    Cell Significance Index: -2.0600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1547
    Cell Significance Index: -1.7800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1551
    Cell Significance Index: -1.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1568
    Cell Significance Index: -3.3400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1605
    Cell Significance Index: -1.7400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1614
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1636
    Cell Significance Index: -2.3500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1638
    Cell Significance Index: -1.8300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1654
    Cell Significance Index: -2.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1697
    Cell Significance Index: -1.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1716
    Cell Significance Index: -1.8200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1730
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1736
    Cell Significance Index: -1.6300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1743
    Cell Significance Index: -2.0600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1765
    Cell Significance Index: -2.1700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1769
    Cell Significance Index: -1.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1771
    Cell Significance Index: -2.4600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1808
    Cell Significance Index: -2.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1810
    Cell Significance Index: -2.0400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1812
    Cell Significance Index: -1.8500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1831
    Cell Significance Index: -2.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1837
    Cell Significance Index: -2.1600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1850
    Cell Significance Index: -1.7900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1853
    Cell Significance Index: -1.6700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1890
    Cell Significance Index: -1.8900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1901
    Cell Significance Index: -2.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1916
    Cell Significance Index: -2.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1956
    Cell Significance Index: -1.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1957
    Cell Significance Index: -2.2400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1961
    Cell Significance Index: -2.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1983
    Cell Significance Index: -2.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1985
    Cell Significance Index: -2.4800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1985
    Cell Significance Index: -2.3000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2021
    Cell Significance Index: -2.1500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2042
    Cell Significance Index: -2.6300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2054
    Cell Significance Index: -1.8100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.2055
    Cell Significance Index: -1.8100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2080
    Cell Significance Index: -2.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2122
    Cell Significance Index: -2.6800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2147
    Cell Significance Index: -2.4700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2155
    Cell Significance Index: -2.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2194
    Cell Significance Index: -2.5900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2197
    Cell Significance Index: -1.7800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2246
    Cell Significance Index: -1.6300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2517
    Cell Significance Index: -2.6500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2528
    Cell Significance Index: -2.9700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2564
    Cell Significance Index: -2.5000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2593
    Cell Significance Index: -2.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2652
    Cell Significance Index: -3.4800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2656
    Cell Significance Index: -2.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2683
    Cell Significance Index: -3.7100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2729
    Cell Significance Index: -3.3200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2732
    Cell Significance Index: -3.6300
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2774
    Cell Significance Index: -2.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2894
    Cell Significance Index: -2.7000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.2941
    Cell Significance Index: -2.0400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3040
    Cell Significance Index: -1.8900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3047
    Cell Significance Index: -2.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3155
    Cell Significance Index: -5.3600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.3237
    Cell Significance Index: -3.5000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3253
    Cell Significance Index: -2.8100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3432
    Cell Significance Index: -3.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA66, also known as small nucleolar RNA, H/ACA box 66, is a small RNA molecule that belongs to the H/ACA box family of small nucleolar RNAs (sRNAs). These sRNAs play a crucial role in regulating RNA processing, ribosome biogenesis, and nucleolus formation. SNORA66 is specifically characterized by its involvement in the H/ACA box-mediated RNA processing pathway, which is essential for the maturation of ribosomal RNA (rRNA) and the formation of functional ribosomes. This gene is also notable for its expression in a wide range of cell types, including cardiac endothelial cells, lymphoid lineage-restricted progenitor cells, and mesenchymal stem cells. **Pathways and Functions:** The expression and functional significance of SNORA66 are intricately linked to various cellular pathways, including RNA processing, nucleolus formation, and immune cell development. SNORA66 is involved in the H/ACA box-mediated RNA processing pathway, which regulates the maturation of rRNA and the formation of functional ribosomes. This process is crucial for protein synthesis and cell growth. Additionally, SNORA66 has been shown to play a role in the regulation of immune cell development and function, particularly in the development of lymphoid lineage-restricted progenitor cells and innate lymphoid cells. Its expression in cardiac endothelial cells suggests a potential role in cardiovascular health and disease. **Clinical Significance:** The clinical significance of SNORA66 is an area of active research, with potential implications for the treatment of various diseases, including cardiovascular and immune system disorders. Studies have shown that alterations in SNORA66 expression are associated with several diseases, including cardiovascular disease, cancer, and autoimmune disorders. For example, decreased expression of SNORA66 has been linked to the development of atherosclerosis, a cardiovascular disease characterized by the buildup of plaque in arterial walls. Furthermore, SNORA66 has been shown to play a role in the regulation of immune cell function, particularly in the context of autoimmune disorders such as rheumatoid arthritis and multiple sclerosis. The identification of SNORA66 as a potential therapeutic target highlights the need for further research into the mechanisms by which this gene regulates cellular processes and disease. In conclusion, the SNORA66 gene is a fascinating area of research that has shed light on the complex relationships between RNA processing, nucleolus formation, and immune cell development. Its clinical significance is an area of active research, with potential implications for the treatment of various diseases, including cardiovascular and immune system disorders. Further studies are needed to fully elucidate the functional significance of SNORA66 and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.