Details for: RNU5B 1

Gene ID: 26832

Symbol: RNU5B 1

Ensembl ID: ENSG00000200156

Description: RNA, U5B small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1415
    Cell Significance Index: 32.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0676
    Cell Significance Index: 48.3900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.8363
    Cell Significance Index: 9.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5045
    Cell Significance Index: 7.5600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.4998
    Cell Significance Index: 4.3700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4281
    Cell Significance Index: 4.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3421
    Cell Significance Index: 6.9600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2390
    Cell Significance Index: 2.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1712
    Cell Significance Index: 6.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1228
    Cell Significance Index: 2.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0836
    Cell Significance Index: 3.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0227
    Cell Significance Index: 0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0153
    Cell Significance Index: 2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0111
    Cell Significance Index: 3.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0083
    Cell Significance Index: 0.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0029
    Cell Significance Index: 0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0067
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0074
    Cell Significance Index: -1.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0216
    Cell Significance Index: -2.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0228
    Cell Significance Index: -4.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0289
    Cell Significance Index: -1.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0478
    Cell Significance Index: -3.0100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0497
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0548
    Cell Significance Index: -0.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0578
    Cell Significance Index: -6.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1073
    Cell Significance Index: -2.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1100
    Cell Significance Index: -5.7300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1146
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1216
    Cell Significance Index: -3.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1227
    Cell Significance Index: -3.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1274
    Cell Significance Index: -1.6000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1448
    Cell Significance Index: -1.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1464
    Cell Significance Index: -5.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1467
    Cell Significance Index: -3.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1499
    Cell Significance Index: -2.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1517
    Cell Significance Index: -3.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1625
    Cell Significance Index: -5.3200
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1686
    Cell Significance Index: -1.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1695
    Cell Significance Index: -5.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1705
    Cell Significance Index: -5.4300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1750
    Cell Significance Index: -1.7900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1759
    Cell Significance Index: -2.1400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1765
    Cell Significance Index: -1.8500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1869
    Cell Significance Index: -1.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1908
    Cell Significance Index: -5.6200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1985
    Cell Significance Index: -1.9900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2093
    Cell Significance Index: -2.9800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2099
    Cell Significance Index: -3.0700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2206
    Cell Significance Index: -3.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2241
    Cell Significance Index: -5.5900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2318
    Cell Significance Index: -2.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2329
    Cell Significance Index: -8.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2371
    Cell Significance Index: -6.0400
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.2409
    Cell Significance Index: -1.8300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2457
    Cell Significance Index: -4.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2468
    Cell Significance Index: -5.4100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2615
    Cell Significance Index: -3.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2667
    Cell Significance Index: -4.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2678
    Cell Significance Index: -5.5900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2690
    Cell Significance Index: -3.4800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2716
    Cell Significance Index: -3.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2747
    Cell Significance Index: -5.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2768
    Cell Significance Index: -5.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2832
    Cell Significance Index: -5.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2845
    Cell Significance Index: -5.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2869
    Cell Significance Index: -5.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2926
    Cell Significance Index: -4.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2965
    Cell Significance Index: -6.3200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3019
    Cell Significance Index: -3.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3146
    Cell Significance Index: -5.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3220
    Cell Significance Index: -5.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3223
    Cell Significance Index: -3.2700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3465
    Cell Significance Index: -4.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3520
    Cell Significance Index: -5.9300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3541
    Cell Significance Index: -4.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3566
    Cell Significance Index: -5.7800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3678
    Cell Significance Index: -3.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3734
    Cell Significance Index: -7.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3740
    Cell Significance Index: -4.7300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3757
    Cell Significance Index: -3.7200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3776
    Cell Significance Index: -4.4400
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.3814
    Cell Significance Index: -3.0100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3845
    Cell Significance Index: -5.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3851
    Cell Significance Index: -3.8900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3860
    Cell Significance Index: -5.7800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3928
    Cell Significance Index: -5.0300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3958
    Cell Significance Index: -4.4600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3974
    Cell Significance Index: -4.6200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3993
    Cell Significance Index: -5.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4046
    Cell Significance Index: -4.5200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4075
    Cell Significance Index: -5.0600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.4134
    Cell Significance Index: -5.0900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4143
    Cell Significance Index: -5.6900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4160
    Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Title: Unveiling the Enigmatic Role of RNU5B1 in Cellular Processes: A Comprehensive Review As an expert immunologist, I am delighted to delve into the intricacies of the RNU5B1 gene, a crucial component of the spliceosomal machinery that plays a pivotal role in RNA processing and cellular homeostasis. In this article, we will explore the key characteristics, pathways, and functions of RNU5B1, as well as its clinical significance in various disease states. Summary: RNU5B1, also known as U5B small nuclear 1, is a non-coding RNA that belongs to the U5 small nuclear ribonucleoprotein (snRNP) family. This gene is highly expressed in various cell types, including neoplastic cells, abnormal cells, goblet cells, absorptive cells, cardiac endothelial cells, intestinal crypt stem cells, transit amplifying cells, cardiac muscle myoblasts, brush cells, and immature innate lymphoid cells. The expression of RNU5B1 is tightly regulated and is often dysregulated in disease states, highlighting its potential as a biomarker and therapeutic target. Key Characteristics: RNU5B1 is a small nuclear RNA (sRNA) that is approximately 100 nucleotides in length. It is a member of the U5 snRNP family, which is responsible for the assembly and maturation of the spliceosome, a complex molecular machine that catalyzes the removal of introns and the joining of exons during RNA splicing. RNU5B1 is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. Pathways and Functions: RNU5B1 is involved in several key pathways, including: 1. Formation of quadruple snRNP complex: RNU5B1 plays a critical role in the assembly of the quadruple snRNP complex, which is essential for the proper functioning of the spliceosome. 2. Spliceosomal tri-snrnp complex assembly: RNU5B1 is also involved in the assembly of the spliceosomal tri-snrnp complex, which is responsible for the recognition and processing of introns. 3. U4/U6 x U5 tri-snrnp complex: RNU5B1 is a key component of the U4/U6 x U5 tri-snrnp complex, which is involved in the catalytic reaction of the spliceosome. The functions of RNU5B1 are multifaceted and include: 1. RNA splicing: RNU5B1 is involved in the recognition and processing of introns, ensuring the proper splicing of RNAs. 2. Quality control: RNU5B1 helps to ensure the accuracy of RNA splicing by monitoring the fidelity of the spliceosome. 3. Regulation of gene expression: RNU5B1 may also play a role in regulating gene expression by influencing the splicing of specific mRNAs. Clinical Significance: The dysregulation of RNU5B1 has been implicated in various disease states, including cancer, neurodegenerative disorders, and immune-mediated diseases. For example: 1. Cancer: RNU5B1 expression is often elevated in cancer cells, suggesting its potential as a biomarker for cancer diagnosis and prognosis. 2. Neurodegenerative disorders: RNU5B1 has been linked to neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, where its dysregulation may contribute to the development of these diseases. 3. Immune-mediated diseases: RNU5B1 may also play a role in the regulation of immune responses, with its dysregulation contributing to the development of autoimmune diseases. In conclusion, RNU5B1 is a critical component of the spliceosomal machinery that plays a multifaceted role in RNA processing, quality control, and regulation of gene expression. Its dysregulation has been implicated in various disease states, highlighting its potential as a biomarker and therapeutic target. Further research is necessary to fully elucidate the functions of RNU5B1 and its role in maintaining cellular homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.