Details for: RNU4 2

Gene ID: 26834

Symbol: RNU4 2

Ensembl ID: ENSG00000202538

Description: RNA, U4 small nuclear 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.0318
    Cell Significance Index: 12.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0253
    Cell Significance Index: 29.5400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.9219
    Cell Significance Index: 9.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7490
    Cell Significance Index: 33.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6912
    Cell Significance Index: 7.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2820
    Cell Significance Index: 13.1500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2396
    Cell Significance Index: 2.7600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2214
    Cell Significance Index: 2.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1542
    Cell Significance Index: 3.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1215
    Cell Significance Index: 4.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0808
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0759
    Cell Significance Index: 12.9600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0707
    Cell Significance Index: 0.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0191
    Cell Significance Index: -0.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0200
    Cell Significance Index: -1.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0269
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0375
    Cell Significance Index: -4.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0568
    Cell Significance Index: -0.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0713
    Cell Significance Index: -1.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0844
    Cell Significance Index: -5.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0925
    Cell Significance Index: -9.6400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1100
    Cell Significance Index: -1.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1358
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1509
    Cell Significance Index: -1.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1736
    Cell Significance Index: -5.5600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1836
    Cell Significance Index: -1.7900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1967
    Cell Significance Index: -2.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2193
    Cell Significance Index: -4.5500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2285
    Cell Significance Index: -4.6500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2344
    Cell Significance Index: -2.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2408
    Cell Significance Index: -3.8200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2413
    Cell Significance Index: -2.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2431
    Cell Significance Index: -7.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2441
    Cell Significance Index: -8.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2545
    Cell Significance Index: -8.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2553
    Cell Significance Index: -7.5200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2584
    Cell Significance Index: -3.4500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2660
    Cell Significance Index: -3.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2683
    Cell Significance Index: -5.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2939
    Cell Significance Index: -10.7900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2947
    Cell Significance Index: -2.6600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2956
    Cell Significance Index: -3.7400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3095
    Cell Significance Index: -7.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3105
    Cell Significance Index: -9.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3109
    Cell Significance Index: -7.9200
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.3123
    Cell Significance Index: -3.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3139
    Cell Significance Index: -5.2800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3308
    Cell Significance Index: -2.0800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3336
    Cell Significance Index: -4.9900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3438
    Cell Significance Index: -4.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3568
    Cell Significance Index: -8.9000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3765
    Cell Significance Index: -4.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3914
    Cell Significance Index: -7.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4138
    Cell Significance Index: -8.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4170
    Cell Significance Index: -8.8500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4182
    Cell Significance Index: -5.4000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4242
    Cell Significance Index: -3.5800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4350
    Cell Significance Index: -4.5800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4382
    Cell Significance Index: -9.1500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4398
    Cell Significance Index: -8.8300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4417
    Cell Significance Index: -4.7000
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.4421
    Cell Significance Index: -3.8900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4475
    Cell Significance Index: -7.6500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4522
    Cell Significance Index: -7.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4563
    Cell Significance Index: -9.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4569
    Cell Significance Index: -7.9000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4593
    Cell Significance Index: -9.0400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4614
    Cell Significance Index: -6.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4791
    Cell Significance Index: -8.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4828
    Cell Significance Index: -5.0400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.4835
    Cell Significance Index: -5.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4855
    Cell Significance Index: -10.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5043
    Cell Significance Index: -4.7800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.5113
    Cell Significance Index: -7.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5208
    Cell Significance Index: -6.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5328
    Cell Significance Index: -9.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5351
    Cell Significance Index: -6.0300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.5355
    Cell Significance Index: -6.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5416
    Cell Significance Index: -7.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5480
    Cell Significance Index: -8.0900
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.5522
    Cell Significance Index: -6.8000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.5548
    Cell Significance Index: -7.0100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5549
    Cell Significance Index: -10.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.5736
    Cell Significance Index: -5.8200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5738
    Cell Significance Index: -5.4500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5845
    Cell Significance Index: -7.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5847
    Cell Significance Index: -8.0300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5976
    Cell Significance Index: -5.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6003
    Cell Significance Index: -8.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU4-2 is a small nuclear RNA (snRNA) that belongs to the U4 family of snRNAs. It is composed of 128 nucleotides and is highly conserved across species. The gene is expressed in a wide range of cell types, including those involved in the immune system, such as immature innate lymphoid cells and intestinal epithelial cells. RNU4-2 is also expressed in neoplastic cells and cardiac muscle myoblasts, suggesting its involvement in the pathogenesis of various diseases. **Pathways and Functions:** RNU4-2 plays a critical role in the formation and function of the spliceosomal machinery, which is responsible for the precise splicing of pre-mRNA. The spliceosome is a complex assembly of snRNPs that recognizes and cleaves the pre-mRNA, resulting in the formation of mature mRNA. RNU4-2 is involved in the assembly of the spliceosomal tri-snRNP complex, which is composed of U4, U6, and U5 snRNAs. This complex is essential for the recognition and cleavage of the pre-mRNA, ensuring accurate gene expression. In addition to its role in splicing, RNU4-2 has been implicated in various cellular processes, including the regulation of cell growth and differentiation. It has been shown to interact with other proteins and RNAs, modulating the activity of the spliceosome and influencing the expression of specific genes. **Clinical Significance:** The dysregulation of RNU4-2 has been implicated in various diseases, including cancer and cardiovascular disease. In cancer, aberrant expression of RNU4-2 has been linked to the development and progression of tumors, suggesting its potential role as a diagnostic biomarker. In cardiovascular disease, RNU4-2 has been shown to play a critical role in the regulation of cardiac cell growth and differentiation, highlighting its potential as a therapeutic target. Furthermore, RNU4-2 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The dysregulation of RNU4-2 has been shown to contribute to the development of autoimmunity, suggesting its potential as a therapeutic target for the treatment of these diseases. In conclusion, RNU4-2 is a crucial component of the spliceosomal machinery, playing a pivotal role in the precise splicing of pre-mRNA and the regulation of cellular processes. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and autoimmune disorders. Further research is needed to fully elucidate the mechanisms underlying the functions of RNU4-2 and to explore its potential as a therapeutic target for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.