Details for: GIP

Gene ID: 2695

Symbol: GIP

Ensembl ID: ENSG00000159224

Description: gastric inhibitory polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.81
    Marker Score: 5253.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.25
    Marker Score: 1848
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3165
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.39
    Marker Score: 1257
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.73
    Marker Score: 1937
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1473
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.3
    Marker Score: 542.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.21
    Marker Score: 1512
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.84
    Marker Score: 558.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 485
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2964
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1128
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 322
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.51
    Marker Score: 562
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 689
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.25
    Marker Score: 499
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.22
    Marker Score: 3508
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.22
    Marker Score: 213
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 90
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 198
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 250
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 178
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 188
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 101
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 69
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.07
    Marker Score: 119.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.07
    Marker Score: 326
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.06
    Marker Score: 33

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Other Information

**Key characteristics:** - The gene is located on chromosome 17p13.1. - It is a protein of the glycoprotein family, which are characterized by their ability to interact with G protein-coupled receptors. - GIP is a secreted protein that is primarily produced in the stomach. - It is a key regulator of gastric acid and mucosal secretions by binding to G protein-coupled receptors on epithelial cells. - It also plays a role in regulating the release of hormones from endocrine cells. **Pathways and functions:** - GIP binds to G protein-coupled receptors on epithelial cells, which are the main cells that secrete gastric acid and mucosal secretions. - This binding triggers a signaling cascade that leads to the activation of adenylate cyclase, which is an enzyme that converts adenosine diphosphate (ADP) into cyclic GMP (cGMP). - cGMP acts on G protein-coupled receptors, which are also expressed on epithelial cells, to inhibit their activity. - This inhibition of epithelial cell activity reduces gastric acid and mucosal secretions. **Clinical significance:** - Mutations in the GIP gene have been linked to several gastrointestinal disorders, including gastroesophageal reflux disease (GERD), gastric ulcers, and colorectal cancer. - GIP is a potential therapeutic target for these disorders, as it can be used to inhibit gastric acid and mucosal secretions and reduce the risk of gastrointestinal complications. **Additional notes:** - GIP is a pleiotropic protein that can have both pro- and anti-inflammatory effects. - It is also involved in the regulation of metabolism, growth, and differentiation.

Genular Protein ID: 3598465070

Symbol: GIP_HUMAN

Name: Gastric inhibitory polypeptide

UniProtKB Accession Codes:

P09681 Q4VB42 Q6NTD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2890159

Title: Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.

PubMed ID: 2890159

DOI: 10.1073/pnas.84.20.7005

PubMed ID: 2739653

Title: Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.

PubMed ID: 2739653

DOI: 10.1210/mend-3-6-1014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6745415

Title: The isolation and sequencing of human gastric inhibitory peptide (GIP).

PubMed ID: 6745415

DOI: 10.1016/0014-5793(84)81114-x

PubMed ID: 15522230

Title: NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide.

PubMed ID: 15522230

DOI: 10.1016/j.bbrc.2004.10.033

Sequence Information:

  • Length: 153
  • Mass: 17108
  • Checksum: 51F5FC388A8897EC
  • Sequence:
    • MVATKTFALL LLSLFLAVGL GEKKEGHFSA LPSLPVGSHA KVSSPQPRGP RYAEGTFISD 
YSIAMDKIHQ QDFVNWLLAQ KGKKNDWKHN ITQREARALE LASQANRKEE EAVEPQSSPA 
KNPSDEDLLR DLLIQELLAC LLDQTNLCRL RSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.