Details for: GCLC

Gene ID: 2729

Symbol: GCLC

Ensembl ID: ENSG00000001084

Description: glutamate-cysteine ligase catalytic subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.09
    Marker Score: 3085
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.05
    Marker Score: 7048
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.77
    Marker Score: 15346
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.54
    Marker Score: 32901
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5
    Marker Score: 1330
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168183
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.43
    Marker Score: 3379
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.41
    Marker Score: 945
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.41
    Marker Score: 14553.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8964
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50251
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.34
    Marker Score: 2547
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.28
    Marker Score: 1010
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.27
    Marker Score: 5500.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.26
    Marker Score: 1424
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.26
    Marker Score: 8007
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2513
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10244
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Marker Score: 2927
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.19
    Marker Score: 4832
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18346
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.15
    Marker Score: 6190.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10909
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.13
    Marker Score: 3697
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.12
    Marker Score: 8321
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 360
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4554.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.09
    Marker Score: 1258
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.09
    Marker Score: 638
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.08
    Marker Score: 1662
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.08
    Marker Score: 730
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.07
    Marker Score: 65531
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.06
    Marker Score: 1056
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.03
    Marker Score: 255
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.03
    Marker Score: 2455
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.02
    Marker Score: 501
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71735
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.97
    Marker Score: 676
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2401
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 462
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 984
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.92
    Marker Score: 438
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.92
    Marker Score: 2238.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.9
    Marker Score: 8446
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.9
    Marker Score: 1634
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.89
    Marker Score: 3455
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.89
    Marker Score: 278
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.88
    Marker Score: 515
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.88
    Marker Score: 765
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.87
    Marker Score: 33208
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4954
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.87
    Marker Score: 253
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.85
    Marker Score: 513
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.85
    Marker Score: 319
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1378
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.81
    Marker Score: 295
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.8
    Marker Score: 548
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.8
    Marker Score: 546
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.8
    Marker Score: 490
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6107.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.79
    Marker Score: 14070.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.78
    Marker Score: 1012
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.77
    Marker Score: 11563
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.77
    Marker Score: 431
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4580
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.76
    Marker Score: 220
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.75
    Marker Score: 652
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3136.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.75
    Marker Score: 14872.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.74
    Marker Score: 490
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.72
    Marker Score: 184
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.72
    Marker Score: 270
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.71
    Marker Score: 1613.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 337
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.7
    Marker Score: 192
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.7
    Marker Score: 328
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.7
    Marker Score: 178.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 339
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.7
    Marker Score: 416
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.68
    Marker Score: 732
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.68
    Marker Score: 15241
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.68
    Marker Score: 397
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.67
    Marker Score: 349
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 235
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 613
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.66
    Marker Score: 278
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2354
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.66
    Marker Score: 729
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.65
    Marker Score: 2998

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Other Information

**Key characteristics:** * GCLC is a protein with a molecular weight of approximately 125 kDa. * It is expressed in a variety of cell types, including immune cells, hepatocytes, and epithelial cells. * GCLC is a key enzyme in the cellular response to stress and injury. * It is involved in the Keap1-nfe2l2 pathway, a major antioxidant defense mechanism. **Pathways and functions:** * GCLC is involved in the biosynthesis of glutathione from glutamate and cysteine. * It is also involved in the degradation of damaged proteins and organelles. * It plays a role in the regulation of cell death and inflammation. * It is involved in the maintenance of redox balance and cellular homeostasis. **Clinical significance:** * Mutations in the GCLC gene have been linked to several human diseases, including haggsd, a genetic disorder characterized by the accumulation of abnormal disulfide bonds in skin and blood proteins. * GCLC inhibitors are being investigated as potential therapeutic agents for these diseases. * Dysregulation of GCLC has been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. **Conclusion:** The GCLC gene is a critical regulator of cellular health and is involved in various cellular processes, including stress response, antioxidant defense, and metabolism. Mutations in the GCLC gene have significant implications for human health, and GCLC inhibitors are a promising area of research for the treatment of various diseases.

Genular Protein ID: 4172073708

Symbol: GSH1_HUMAN

Name: GCS heavy chain

UniProtKB Accession Codes:

P48506 Q14399

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1350904

Title: Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase.

PubMed ID: 1350904

DOI: 10.1016/s0006-291x(05)80950-7

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7726839

Title: Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene.

PubMed ID: 7726839

DOI: 10.1006/bbrc.1995.1493

PubMed ID: 10515893

Title: The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency.

PubMed ID: 10515893

PubMed ID: 9675072

Title: Expression and purification of human gamma-glutamylcysteine synthetase.

PubMed ID: 9675072

DOI: 10.1006/prep.1998.0897

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10733484

Title: A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia.

PubMed ID: 10733484

PubMed ID: 12663448

Title: A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.

PubMed ID: 12663448

DOI: 10.1182/blood-2002-11-3622

Sequence Information:

  • Length: 637
  • Mass: 72766
  • Checksum: 511F33F106A15504
  • Sequence:
    • MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 
ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 
EANMRKRRKE ATSILEENQA LCTITSFPRL GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI 
NKHPRFSTLT RNIRHRRGEK VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA 
MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 
SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLQ 
EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 
GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL 
QGMFYFRKDI CKGGNAVVDG CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS 
YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS 
LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN

Genular Protein ID: 3090199357

Symbol: E1CEI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E1CEI4 H0Y9I7

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SUPFAM 1 UCSC 2 UniPathway 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 599
  • Mass: 68630
  • Checksum: FFAA66F69EAF2271
  • Sequence:
    • MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH 
ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 
EANMRKRRKE ATSILEENQA LCTITSFPST LTRNIRHRRG EKVVINVPIF KDKNTPSPFI 
ETFTEDDEAS RASKPDHIYM DAMGFGMGNC CLQVTFQACS ISEARYLYDQ LATICPIVMA 
LSAASPFYRG YVSDIDCRWG VISASVDDRT REERGLEPLK NNNYRISKSR YDSIDSYLSK 
CGEKYNDIDL TIDKEIYEQL LQEGIDHLLA QHVAHLFIRD PLTLFEEKIH LDDANESDHF 
ENIQSTNWQT MRFKPPPPNS DIGWRVEFRP MEVQLTDFEN SAYVVFVVLL TRVILSYKLD 
FLIPLSKVDE NMKVAQKRDA VLQGMFYFRK DICKGGNAVV DGCGKAQNST ELAAEEYTLM 
SIDTIINGKE GVFPGLIPIL NSYLENMEVD VDTRCSILNY LKLIKKRASG ELMTVARWMR 
EFIANHPDYK QDSVITDEMN YSLILKCNQI ANELCECPEL LGSAFRKVKY SGSKTDSSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.