Details for: BMP10

Gene ID: 27302

Symbol: BMP10

Ensembl ID: ENSG00000163217

Description: bone morphogenetic protein 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3841
    Cell Significance Index: 5.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2333
    Cell Significance Index: 3.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1336
    Cell Significance Index: 1.6000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0659
    Cell Significance Index: 0.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0499
    Cell Significance Index: 0.7100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0458
    Cell Significance Index: 0.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0377
    Cell Significance Index: 0.5400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0234
    Cell Significance Index: 0.5900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0133
    Cell Significance Index: 0.1800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0107
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0025
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0039
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0040
    Cell Significance Index: -1.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0059
    Cell Significance Index: -0.8600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0089
    Cell Significance Index: -1.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0251
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0269
    Cell Significance Index: -1.8100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0313
    Cell Significance Index: -0.3100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0401
    Cell Significance Index: -0.4800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0443
    Cell Significance Index: -0.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0451
    Cell Significance Index: -0.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0504
    Cell Significance Index: -2.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0512
    Cell Significance Index: -1.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0634
    Cell Significance Index: -1.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0634
    Cell Significance Index: -1.8100
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0657
    Cell Significance Index: -0.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0663
    Cell Significance Index: -1.7700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0674
    Cell Significance Index: -0.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0710
    Cell Significance Index: -1.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0731
    Cell Significance Index: -1.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0734
    Cell Significance Index: -1.8300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0749
    Cell Significance Index: -0.7900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0788
    Cell Significance Index: -1.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0800
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0803
    Cell Significance Index: -2.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0808
    Cell Significance Index: -2.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0817
    Cell Significance Index: -1.7900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0866
    Cell Significance Index: -0.9200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0887
    Cell Significance Index: -1.2300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0916
    Cell Significance Index: -1.7900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0963
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1043
    Cell Significance Index: -0.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1059
    Cell Significance Index: -1.8100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1083
    Cell Significance Index: -1.3600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1136
    Cell Significance Index: -1.5600
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1142
    Cell Significance Index: -1.3900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1146
    Cell Significance Index: -1.4500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1159
    Cell Significance Index: -0.9900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1172
    Cell Significance Index: -1.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1176
    Cell Significance Index: -1.1000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1191
    Cell Significance Index: -1.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1196
    Cell Significance Index: -1.7700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1200
    Cell Significance Index: -1.4000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1204
    Cell Significance Index: -1.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1252
    Cell Significance Index: -3.5900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1309
    Cell Significance Index: -1.3900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1349
    Cell Significance Index: -1.6400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1370
    Cell Significance Index: -1.7600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1380
    Cell Significance Index: -1.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1383
    Cell Significance Index: -1.8200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1406
    Cell Significance Index: -1.3200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1431
    Cell Significance Index: -2.8300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1444
    Cell Significance Index: -1.5900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1448
    Cell Significance Index: -1.7600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1451
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1456
    Cell Significance Index: -1.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1459
    Cell Significance Index: -1.5900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1463
    Cell Significance Index: -1.9100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1464
    Cell Significance Index: -1.5700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1466
    Cell Significance Index: -0.8700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1486
    Cell Significance Index: -1.6600
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.1490
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1514
    Cell Significance Index: -1.8000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1523
    Cell Significance Index: -1.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1537
    Cell Significance Index: -1.5700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1543
    Cell Significance Index: -1.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1557
    Cell Significance Index: -1.5800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1573
    Cell Significance Index: -1.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1588
    Cell Significance Index: -2.2800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1599
    Cell Significance Index: -2.5900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1607
    Cell Significance Index: -1.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1614
    Cell Significance Index: -2.7900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1617
    Cell Significance Index: -1.7900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1625
    Cell Significance Index: -1.9200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1646
    Cell Significance Index: -1.8700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1651
    Cell Significance Index: -1.9000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1696
    Cell Significance Index: -1.5300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1697
    Cell Significance Index: -1.6600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1704
    Cell Significance Index: -1.2400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1709
    Cell Significance Index: -1.7700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1740
    Cell Significance Index: -1.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BMP10 is a secreted protein that belongs to the transforming growth factor-beta (TGF-β) superfamily. It is primarily expressed in the heart and other tissues, including the kidney and cartilage. BMP10 has a unique structure, consisting of 10 conserved cysteine residues and a propeptide domain. Its expression is highly regulated during embryonic development and is involved in the specification and differentiation of cardiac cells. **Pathways and Functions:** BMP10 plays a critical role in cardiac development and function through several signaling pathways, including: 1. **Activin Receptor Signaling Pathway:** BMP10 binds to the activin receptor type II (ACTR2) and type I (ACTR1) to activate the Smad-dependent signaling pathway, which regulates cardiac cell proliferation and differentiation. 2. **BMP Signaling Pathway:** BMP10 interacts with the BMP receptor complex to activate the BMP-specific Smad pathway, which regulates cardiac muscle cell hypertrophy and organization. 3. **Cardiac Muscle Cell Proliferation:** BMP10 promotes the proliferation of cardiac muscle cells by regulating the expression of cell cycle-related genes and inhibiting apoptosis. 4. **Negative Regulation of Cardiac Muscle Hypertrophy:** BMP10 also plays a role in regulating cardiac muscle hypertrophy by inhibiting the activity of pro-hypertrophic factors, such as TGF-β. **Clinical Significance:** Dysregulation of BMP10 has been implicated in various cardiac diseases, including: 1. **Cardiac Hypertrophy:** Mutations in the BMP10 gene have been associated with familial hypertrophic cardiomyopathy, a condition characterized by abnormal cardiac muscle cell growth and hypertrophy. 2. **Cardiac Developmental Dysplasia:** BMP10 is essential for the proper development of the heart and other tissues. Mutations in the BMP10 gene can lead to cardiac developmental dysplasia, a condition characterized by abnormal heart development and function. 3. **Atrial Fibrillation:** BMP10 has been implicated in the regulation of atrial cardiac muscle cell proliferation and organization, which is critical for maintaining normal cardiac rhythm. Dysregulation of BMP10 has been associated with atrial fibrillation, a common cardiac arrhythmia. In conclusion, BMP10 plays a critical role in cardiac development and function, and its dysregulation has been implicated in various cardiac diseases. Further research is needed to fully understand the mechanisms by which BMP10 regulates cardiac cell proliferation, differentiation, and hypertrophy, as well as its clinical significance in cardiac disease. **References:** * [Insert relevant references] Note: This article is a comprehensive review of the gene BMP10, its characteristics, pathways, and functions, and its clinical significance in cardiac diseases. The references provided are fictional and for demonstration purposes only.

Genular Protein ID: 848554461

Symbol: BMP10_HUMAN

Name: Bone morphogenetic protein 10

UniProtKB Accession Codes:

O95393 Q53R17 Q6NTE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16049014

Title: Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses.

PubMed ID: 16049014

DOI: 10.1074/jbc.m504629200

PubMed ID: 17068149

Title: Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.

PubMed ID: 17068149

DOI: 10.1182/blood-2006-07-034124

PubMed ID: 18339631

Title: Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

PubMed ID: 18339631

DOI: 10.1074/jbc.m707820200

PubMed ID: 21737454

Title: Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

PubMed ID: 21737454

DOI: 10.1074/jbc.m111.260133

PubMed ID: 20608934

Title: Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer.

PubMed ID: 20608934

DOI: 10.1111/j.1349-7006.2010.01648.x

Sequence Information:

  • Length: 424
  • Mass: 48047
  • Checksum: 3FDB3B7221BB2254
  • Sequence:
    • MGSLVLTLCA LFCLAAYLVS GSPIMNLEQS PLEEDMSLFG DVFSEQDGVD FNTLLQSMKD 
EFLKTLNLSD IPTQDSAKVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVSF 
NGLRKYPLLF NVSIPHHEEV IMAELRLYTL VQRDRMIYDG VDRKITIFEV LESKGDNEGE 
RNMLVLVSGE IYGTNSEWET FDVTDAIRRW QKSGSSTHQL EVHIESKHDE AEDASSGRLE 
IDTSAQNKHN PLLIVFSDDQ SSDKERKEEL NEMISHEQLP ELDNLGLDSF SSGPGEEALL 
QMRSNIIYDS TARIRRNAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL 
AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE 
CGCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.