Details for: GNGT2

Gene ID: 2793

Symbol: GNGT2

Ensembl ID: ENSG00000167083

Description: G protein subunit gamma transducin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.36
    Marker Score: 2568
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2307
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5307
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 551
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12480
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.75
    Marker Score: 2073
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.7
    Marker Score: 776
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.69
    Marker Score: 246
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.6
    Marker Score: 1167
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.55
    Marker Score: 1571
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.48
    Marker Score: 227
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.47
    Marker Score: 579
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.46
    Marker Score: 336
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.45
    Marker Score: 1309
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.43
    Marker Score: 426
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.42
    Marker Score: 423
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.41
    Marker Score: 993
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.4
    Marker Score: 1035
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.39
    Marker Score: 10107
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.35
    Marker Score: 4109
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.34
    Marker Score: 3407
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.32
    Marker Score: 130
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 209
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.32
    Marker Score: 342
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.31
    Marker Score: 910
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.31
    Marker Score: 176
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.29
    Marker Score: 95
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.29
    Marker Score: 131
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.29
    Marker Score: 360
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.29
    Marker Score: 806
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.29
    Marker Score: 710
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.27
    Marker Score: 348
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.27
    Marker Score: 153
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.26
    Marker Score: 57
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.25
    Marker Score: 710
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.24
    Marker Score: 175
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.24
    Marker Score: 1523
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.24
    Marker Score: 316
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.24
    Marker Score: 83
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 76
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.23
    Marker Score: 342
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1527.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.22
    Marker Score: 707
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.22
    Marker Score: 188
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.22
    Marker Score: 402
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.22
    Marker Score: 166
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 127
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 190
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.21
    Marker Score: 187
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.2
    Marker Score: 1199
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.2
    Marker Score: 343
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.19
    Marker Score: 97
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.19
    Marker Score: 161
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.19
    Marker Score: 168
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.19
    Marker Score: 152
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.18
    Marker Score: 360
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.18
    Marker Score: 139
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.18
    Marker Score: 120
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 102.5
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.18
    Marker Score: 116
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.18
    Marker Score: 205
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.18
    Marker Score: 126
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.18
    Marker Score: 137
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.17
    Marker Score: 176
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 165
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.17
    Marker Score: 710
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 222
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.17
    Marker Score: 38

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Other Information

**Key characteristics:** * GNGT2 is a G protein subunit that is involved in the regulation of water and electrolyte transport. * It is expressed in a variety of cell types, including cardiac endothelial cells, immature innate lymphoid cells, and cerebral cortex GABAergic interneurons. * GNGT2 is a transmembrane protein that is responsible for the regulation of water and electrolyte transport. * It is involved in the regulation of blood volume, blood pressure, and cardiac function. * It is also involved in the regulation of inflammation and cell signaling. **Pathways and functions:** * GNGT2 is involved in the regulation of water and electrolyte transport in the body. * It is involved in the regulation of blood volume, blood pressure, and cardiac function. * It is also involved in the regulation of inflammation and cell signaling. **Clinical significance:** * Mutations in GNGT2 have been linked to a variety of human diseases, including congestive heart failure, hypertension, and cerebral ischemia. * GNGT2 is a potential target for the treatment of these diseases. **Additional information:** * GNGT2 is a member of the G protein-coupled receptor family. * It is a ubiquitin-dependent protein that is regulated by the ubiquitin-proteasome pathway. * It is a highly conserved protein that is found in organisms from yeast to humans.

Genular Protein ID: 2415845683

Symbol: GBGT2_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

UniProtKB Accession Codes:

O14610 B2R746 D3DTW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 5 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 27 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9286705

Title: Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2).

PubMed ID: 9286705

DOI: 10.1006/geno.1997.4814

PubMed ID: 11714923

Title: Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms.

PubMed ID: 11714923

DOI: 10.1110/ps.ps.26401

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 69
  • Mass: 7747
  • Checksum: 7ABD417F097F719B
  • Sequence:
    • MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL KGIPEDKNPF 
KEKGGCLIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.