Details for: MRGPRG AS1

Gene ID: 283303

Symbol: MRGPRG AS1

Ensembl ID: ENSG00000236301

Description: MRGPRG antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.3206
    Cell Significance Index: 2.3100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0935
    Cell Significance Index: 1.2200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0876
    Cell Significance Index: 1.0700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0758
    Cell Significance Index: 0.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0587
    Cell Significance Index: 0.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0535
    Cell Significance Index: 0.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0419
    Cell Significance Index: 0.6000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.0399
    Cell Significance Index: 0.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0371
    Cell Significance Index: 0.4700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0222
    Cell Significance Index: 0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0121
    Cell Significance Index: 0.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0117
    Cell Significance Index: 0.1600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0114
    Cell Significance Index: 0.1400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0097
    Cell Significance Index: 0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0078
    Cell Significance Index: 0.0900
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.0005
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0009
    Cell Significance Index: -0.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0020
    Cell Significance Index: -0.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0027
    Cell Significance Index: -0.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0035
    Cell Significance Index: -0.1700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0053
    Cell Significance Index: -0.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0068
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0073
    Cell Significance Index: -0.0700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0099
    Cell Significance Index: -0.1600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0106
    Cell Significance Index: -0.1200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0107
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0114
    Cell Significance Index: -0.2200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0121
    Cell Significance Index: -0.1600
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0121
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0122
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0123
    Cell Significance Index: -0.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0129
    Cell Significance Index: -0.3400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0130
    Cell Significance Index: -0.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0130
    Cell Significance Index: -0.1400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0130
    Cell Significance Index: -0.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0131
    Cell Significance Index: -0.1300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0132
    Cell Significance Index: -0.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0141
    Cell Significance Index: -0.1100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0142
    Cell Significance Index: -0.1500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0153
    Cell Significance Index: -0.1600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0155
    Cell Significance Index: -0.1900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0161
    Cell Significance Index: -0.2700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0162
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0164
    Cell Significance Index: -0.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0170
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0173
    Cell Significance Index: -0.1600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0180
    Cell Significance Index: -0.1200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0180
    Cell Significance Index: -0.1400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0188
    Cell Significance Index: -0.1400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0194
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0200
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0205
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0209
    Cell Significance Index: -0.2400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0212
    Cell Significance Index: -0.2300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0220
    Cell Significance Index: -0.2500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0228
    Cell Significance Index: -0.3000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0231
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0250
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRGPRG AS1 is a non-coding RNA antisense to the MRGPRG gene, which is located on chromosome 2q37.1. The gene is primarily expressed in cells of the nervous system, including oligodendrocyte precursor cells, progenitor cells, neuronal receptor cells, microglial cells, and smooth muscle myoblasts. Its expression is also notable in blood vessel endothelial cells, erythrocytes, squamous epithelial cells, and lymphoid lineage-restricted progenitor cells. The widespread expression of MRGPRG AS1 across these cell types suggests a critical role in regulating cellular processes, including development, differentiation, and immune responses. **Pathways and Functions:** The molecular mechanisms underlying the functions of MRGPRG AS1 are not yet fully elucidated. However, several key pathways have been implicated in its regulation. These include: 1. **Notch signaling pathway**: MRGPRG AS1 has been shown to interact with the Notch signaling pathway, a critical regulator of cell fate decisions and differentiation. 2. **Wnt/β-catenin pathway**: MRGPRG AS1 has also been implicated in the regulation of the Wnt/β-catenin pathway, which plays a key role in cell proliferation, differentiation, and survival. 3. **MicroRNA-mediated regulation**: MRGPRG AS1 may also function as a regulator of microRNA expression, influencing the post-transcriptional regulation of target genes. The functions of MRGPRG AS1 are likely multifaceted, involving regulation of cellular processes such as: 1. **Neuronal development and differentiation**: MRGPRG AS1 may play a critical role in regulating the development and differentiation of neurons, particularly in the context of neurological disorders. 2. **Immune cell function**: MRGPRG AS1 may influence the function and development of immune cells, including microglial cells and lymphoid lineage-restricted progenitor cells. 3. **Vascular development and maintenance**: MRGPRG AS1 may also be involved in the regulation of vascular development and maintenance, particularly in the context of cardiovascular diseases. **Clinical Significance:** The clinical significance of MRGPRG AS1 is an active area of research. Emerging evidence suggests that dysregulation of MRGPRG AS1 may contribute to a range of diseases, including: 1. **Neurological disorders**: MRGPRG AS1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immune-related disorders**: MRGPRG AS1 may also play a role in the development of immune-related disorders, including autoimmune diseases and cancer. 3. **Cardiovascular diseases**: MRGPRG AS1 may influence the development and progression of cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. In conclusion, the MRGPRG AS1 gene is a complex and multifaceted component of the human genome, with significant implications for our understanding of cellular development, differentiation, and immune function. Further research is needed to fully elucidate the mechanisms of action of MRGPRG AS1 and its clinical significance, but the current evidence suggests that it is a critical regulator of various biological processes.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.