Details for: IGHV6 1

Gene ID: 28385

Symbol: IGHV6 1

Ensembl ID: ENSG00000211933

Description: immunoglobulin heavy variable 6-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.6603
    Cell Significance Index: -2.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.6213
    Cell Significance Index: 9.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4453
    Cell Significance Index: 6.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0405
    Cell Significance Index: -2.6200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0954
    Cell Significance Index: -1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1190
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1370
    Cell Significance Index: -6.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1716
    Cell Significance Index: -2.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2013
    Cell Significance Index: -5.0300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2174
    Cell Significance Index: -2.4300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2274
    Cell Significance Index: -1.9100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2447
    Cell Significance Index: -2.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2525
    Cell Significance Index: -9.2700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2572
    Cell Significance Index: -3.0400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2669
    Cell Significance Index: -6.4700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2903
    Cell Significance Index: -3.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2910
    Cell Significance Index: -4.8700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2926
    Cell Significance Index: -2.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3107
    Cell Significance Index: -4.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3109
    Cell Significance Index: -7.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3130
    Cell Significance Index: -6.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3160
    Cell Significance Index: -5.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3303
    Cell Significance Index: -15.4000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3352
    Cell Significance Index: -5.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3417
    Cell Significance Index: -5.5400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3587
    Cell Significance Index: -4.2200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3670
    Cell Significance Index: -4.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4003
    Cell Significance Index: -5.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4206
    Cell Significance Index: -5.5000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4231
    Cell Significance Index: -3.4000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.4340
    Cell Significance Index: -4.4900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4526
    Cell Significance Index: -4.2000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.4664
    Cell Significance Index: -5.2800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4671
    Cell Significance Index: -5.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4767
    Cell Significance Index: -5.9600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4770
    Cell Significance Index: -6.2600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4817
    Cell Significance Index: -3.2100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4822
    Cell Significance Index: -8.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4832
    Cell Significance Index: -5.5300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4898
    Cell Significance Index: -4.1800
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.4949
    Cell Significance Index: -5.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4950
    Cell Significance Index: -25.7200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.5009
    Cell Significance Index: -5.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5071
    Cell Significance Index: -6.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5102
    Cell Significance Index: -5.7000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5130
    Cell Significance Index: -5.6200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5221
    Cell Significance Index: -4.9400
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.5221
    Cell Significance Index: -5.3000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5234
    Cell Significance Index: -5.5600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5283
    Cell Significance Index: -6.2400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.5306
    Cell Significance Index: -5.6700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5310
    Cell Significance Index: -6.4600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5311
    Cell Significance Index: -5.8800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5357
    Cell Significance Index: -5.7600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.5411
    Cell Significance Index: -5.8500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.5414
    Cell Significance Index: -5.5700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.5414
    Cell Significance Index: -5.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5475
    Cell Significance Index: -5.1900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.5530
    Cell Significance Index: -5.0400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.5545
    Cell Significance Index: -5.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5617
    Cell Significance Index: -6.5200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5628
    Cell Significance Index: -6.6900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.5647
    Cell Significance Index: -5.5700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.5718
    Cell Significance Index: -5.1000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5730
    Cell Significance Index: -5.5000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5744
    Cell Significance Index: -6.5300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5746
    Cell Significance Index: -6.3900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5763
    Cell Significance Index: -6.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5773
    Cell Significance Index: -6.2900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5792
    Cell Significance Index: -6.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5799
    Cell Significance Index: -6.5400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.5823
    Cell Significance Index: -5.5700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.5850
    Cell Significance Index: -6.3900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5865
    Cell Significance Index: -6.2400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.5927
    Cell Significance Index: -5.3500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5929
    Cell Significance Index: -7.7400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5940
    Cell Significance Index: -6.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5956
    Cell Significance Index: -7.9200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.5965
    Cell Significance Index: -7.2000
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5971
    Cell Significance Index: -5.8300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.5981
    Cell Significance Index: -6.3900
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.5998
    Cell Significance Index: -6.2200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.6012
    Cell Significance Index: -6.3300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.6023
    Cell Significance Index: -6.5300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6049
    Cell Significance Index: -6.7000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.6089
    Cell Significance Index: -5.4400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.6092
    Cell Significance Index: -6.4600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.6093
    Cell Significance Index: -5.4000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.6098
    Cell Significance Index: -6.3500
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.6121
    Cell Significance Index: -5.6800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.6136
    Cell Significance Index: -8.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6190
    Cell Significance Index: -6.5300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.6200
    Cell Significance Index: -5.6700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6240
    Cell Significance Index: -5.8100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6245
    Cell Significance Index: -6.3700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.6253
    Cell Significance Index: -5.6800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.6270
    Cell Significance Index: -5.9600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.6273
    Cell Significance Index: -6.1200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.6278
    Cell Significance Index: -5.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV6-1 is a member of the immunoglobulin heavy chain family, which is responsible for the specificity and diversity of the immune response. The IGHV6-1 gene is composed of a variable (V) region, a diversity (D) region, and a joining (J) region, which are critical for the generation of antigen-specific antibodies. The expression of IGHV6-1 is restricted to specific cell types, including CD16-positive natural killer cells, which are involved in innate immunity. The gene's expression is also observed in neoplastic cells, suggesting its potential role in cancer development and progression. **Pathways and Functions:** IGHV6-1 is involved in several key pathways, including: 1. **Antigen Binding**: IGHV6-1 encodes for the heavy chain of immunoglobulins, which bind to specific antigens, triggering an immune response. 2. **Immunoglobulin Complex Formation**: IGHV6-1 interacts with other immunoglobulin chains to form a complete immunoglobulin molecule, which is essential for the recognition and neutralization of pathogens. 3. **Immunoglobulin-Mediated Immune Response**: IGHV6-1 plays a critical role in the activation of B cells and the production of antibody-mediated immune responses. 4. **Plasma Membrane Signaling**: IGHV6-1 is also involved in signaling pathways that regulate cell growth, differentiation, and survival. **Clinical Significance:** The expression of IGHV6-1 has significant clinical implications, including: 1. **Innate Immunity**: The expression of IGHV6-1 in natural killer cells highlights the importance of innate immunity in the early stages of infection. 2. **Cancer Development**: The expression of IGHV6-1 in neoplastic cells suggests its potential role in cancer development and progression. 3. **Immunoglobulin-Related Disorders**: Abnormalities in IGHV6-1 expression may contribute to the development of immunoglobulin-related disorders, such as autoimmune diseases and cancer. 4. **Vaccine Development**: The understanding of IGHV6-1's role in antigen binding and immunoglobulin complex formation may inform the development of novel vaccines. In conclusion, the IGHV6-1 gene plays a critical role in the human immune system, particularly in the recognition and neutralization of pathogens. Further research is necessary to fully elucidate the functions and clinical significance of IGHV6-1, which may have significant implications for the development of novel therapeutic strategies and vaccine formulations.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.