Details for: IGHV3 43

Gene ID: 28426

Symbol: IGHV3 43

Ensembl ID: ENSG00000232216

Description: immunoglobulin heavy variable 3-43

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6196
    Cell Significance Index: 6.9300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3529
    Cell Significance Index: 5.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1698
    Cell Significance Index: 2.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0056
    Cell Significance Index: -4.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0105
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0405
    Cell Significance Index: -4.1400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0481
    Cell Significance Index: -0.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0607
    Cell Significance Index: -3.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0657
    Cell Significance Index: -8.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0669
    Cell Significance Index: -1.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1000
    Cell Significance Index: -2.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1090
    Cell Significance Index: -2.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1135
    Cell Significance Index: -8.4600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1507
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1537
    Cell Significance Index: -26.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1555
    Cell Significance Index: -4.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1730
    Cell Significance Index: -4.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1744
    Cell Significance Index: -4.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1968
    Cell Significance Index: -5.2600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1969
    Cell Significance Index: -2.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2148
    Cell Significance Index: -4.2000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2290
    Cell Significance Index: -2.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2316
    Cell Significance Index: -5.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2396
    Cell Significance Index: -3.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2404
    Cell Significance Index: -4.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2435
    Cell Significance Index: -4.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2450
    Cell Significance Index: -4.1000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2623
    Cell Significance Index: -3.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2801
    Cell Significance Index: -8.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2822
    Cell Significance Index: -3.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2862
    Cell Significance Index: -13.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2910
    Cell Significance Index: -3.9900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2916
    Cell Significance Index: -2.9600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2969
    Cell Significance Index: -1.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3012
    Cell Significance Index: -3.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3114
    Cell Significance Index: -4.0300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3276
    Cell Significance Index: -3.6600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3281
    Cell Significance Index: -3.8600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3392
    Cell Significance Index: -2.8000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3521
    Cell Significance Index: -3.7400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3521
    Cell Significance Index: -4.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3522
    Cell Significance Index: -4.4500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3551
    Cell Significance Index: -3.8900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3598
    Cell Significance Index: -3.9500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3659
    Cell Significance Index: -4.2100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3709
    Cell Significance Index: -2.3000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3742
    Cell Significance Index: -4.7000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3775
    Cell Significance Index: -4.0700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3801
    Cell Significance Index: -3.2400
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3864
    Cell Significance Index: -4.2200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3866
    Cell Significance Index: -4.0700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3903
    Cell Significance Index: -4.0200
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.3907
    Cell Significance Index: -3.1400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3962
    Cell Significance Index: -4.9500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3965
    Cell Significance Index: -4.3900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3965
    Cell Significance Index: -4.8200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4058
    Cell Significance Index: -4.6700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4065
    Cell Significance Index: -2.9200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.4115
    Cell Significance Index: -4.4700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.4138
    Cell Significance Index: -4.4200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4141
    Cell Significance Index: -4.5300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4157
    Cell Significance Index: -3.9900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4162
    Cell Significance Index: -4.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4162
    Cell Significance Index: -5.5300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4175
    Cell Significance Index: -3.8900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.4179
    Cell Significance Index: -4.4700
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4187
    Cell Significance Index: -4.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4211
    Cell Significance Index: -4.4800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4222
    Cell Significance Index: -4.7000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4230
    Cell Significance Index: -4.5200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4238
    Cell Significance Index: -4.0100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.4242
    Cell Significance Index: -4.1900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.4243
    Cell Significance Index: -3.9200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4255
    Cell Significance Index: -4.5800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4256
    Cell Significance Index: -3.9500
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4268
    Cell Significance Index: -3.8400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4273
    Cell Significance Index: -4.1700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4282
    Cell Significance Index: -5.0600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4285
    Cell Significance Index: -4.3500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.4373
    Cell Significance Index: -4.5300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4414
    Cell Significance Index: -4.1100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.4427
    Cell Significance Index: -4.2400
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4465
    Cell Significance Index: -4.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4521
    Cell Significance Index: -4.3500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4555
    Cell Significance Index: -5.2900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4556
    Cell Significance Index: -3.9900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4569
    Cell Significance Index: -5.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4588
    Cell Significance Index: -4.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4610
    Cell Significance Index: -7.8300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4619
    Cell Significance Index: -4.1200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.4632
    Cell Significance Index: -4.8000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4659
    Cell Significance Index: -4.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4663
    Cell Significance Index: -5.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4667
    Cell Significance Index: -5.5100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4694
    Cell Significance Index: -4.9200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.4699
    Cell Significance Index: -4.8000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4708
    Cell Significance Index: -5.0000
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.4712
    Cell Significance Index: -4.0600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4718
    Cell Significance Index: -4.2000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4726
    Cell Significance Index: -4.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The IGHV3-43 gene is located on chromosome 14q32.33, a region known for encoding immunoglobulin genes. 2. **Expression:** This gene is significantly expressed in various cell types, including granulocyte monocyte progenitor cells, goblet cells, and intestinal epithelial cells. 3. **Function:** IGHV3-43 encodes the variable region of the heavy chain of immunoglobulins, which is essential for antigen recognition and binding. 4. **Structure:** The IGHV3-43 gene is a single copy gene, with a single exon encoding the variable region of the heavy chain. **Pathways and Functions:** 1. **Antigen Binding:** The IGHV3-43 gene plays a crucial role in the production of antibodies that recognize and bind to specific antigens, triggering an immune response. 2. **Immunoglobulin Complex Formation:** The variable region encoded by IGHV3-43 forms a complex with the constant region of the heavy chain and the light chain, resulting in the formation of a mature immunoglobulin molecule. 3. **Immunoglobulin-Mediated Immune Response:** The IGHV3-43 gene is involved in the activation of B cells and the production of antibodies, which are essential for the immune response against pathogens. 4. **Extracellular Region:** The IGHV3-43 gene is part of the extracellular region of immunoglobulins, which interacts with antigens and other immune molecules. **Clinical Significance:** 1. **Autoimmune Diseases:** Abnormalities in the IGHV3-43 gene have been implicated in various autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** Mutations in the IGHV3-43 gene have been associated with certain types of cancer, including lymphoma and leukemia. 3. **Immunodeficiency Disorders:** Defects in the IGHV3-43 gene can lead to immunodeficiency disorders, such as agammaglobulinemia and X-linked agammaglobulinemia. 4. **Transplantation Rejection:** The IGHV3-43 gene plays a crucial role in the recognition of foreign antigens, making it a target for immunosuppressive therapies in organ transplantation. In conclusion, the IGHV3-43 gene is a vital component of the immune system, playing a crucial role in the production of antibodies that recognize and bind to specific antigens. Abnormalities in this gene have been implicated in various autoimmune diseases, cancer, immunodeficiency disorders, and transplantation rejection. Further research is necessary to fully understand the clinical significance of the IGHV3-43 gene and its role in the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.