Details for: IGHV1 24

Gene ID: 28467

Symbol: IGHV1 24

Ensembl ID: ENSG00000211950

Description: immunoglobulin heavy variable 1-24

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6412
    Cell Significance Index: 9.9200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.3487
    Cell Significance Index: 4.1400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.3331
    Cell Significance Index: 2.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0141
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0195
    Cell Significance Index: -3.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0254
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0320
    Cell Significance Index: -3.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0446
    Cell Significance Index: -4.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0579
    Cell Significance Index: -1.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0636
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0657
    Cell Significance Index: -8.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0864
    Cell Significance Index: -2.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1143
    Cell Significance Index: -8.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1194
    Cell Significance Index: -3.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1487
    Cell Significance Index: -3.9100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1589
    Cell Significance Index: -1.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1604
    Cell Significance Index: -7.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1626
    Cell Significance Index: -5.9700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1635
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1637
    Cell Significance Index: -1.8600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1646
    Cell Significance Index: -2.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1761
    Cell Significance Index: -4.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1765
    Cell Significance Index: -2.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1823
    Cell Significance Index: -1.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2041
    Cell Significance Index: -5.2000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2121
    Cell Significance Index: -2.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2131
    Cell Significance Index: -3.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2151
    Cell Significance Index: -4.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2170
    Cell Significance Index: -4.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2286
    Cell Significance Index: -10.6600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2372
    Cell Significance Index: -2.6500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2399
    Cell Significance Index: -4.1000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2488
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2540
    Cell Significance Index: -29.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2542
    Cell Significance Index: -4.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2551
    Cell Significance Index: -3.4700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2613
    Cell Significance Index: -2.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2654
    Cell Significance Index: -3.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2791
    Cell Significance Index: -8.0000
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.2847
    Cell Significance Index: -2.1900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2947
    Cell Significance Index: -4.3100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2958
    Cell Significance Index: -3.4800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3008
    Cell Significance Index: -3.5600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3009
    Cell Significance Index: -2.5700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3014
    Cell Significance Index: -3.9000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3043
    Cell Significance Index: -3.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3250
    Cell Significance Index: -3.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3277
    Cell Significance Index: -7.5700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3370
    Cell Significance Index: -4.0700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3423
    Cell Significance Index: -3.6900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3455
    Cell Significance Index: -4.3400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3514
    Cell Significance Index: -3.9600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3610
    Cell Significance Index: -3.9800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3648
    Cell Significance Index: -4.1300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3664
    Cell Significance Index: -2.4400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3697
    Cell Significance Index: -4.0500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3719
    Cell Significance Index: -3.5400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3730
    Cell Significance Index: -4.6600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3754
    Cell Significance Index: -4.3200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3780
    Cell Significance Index: -3.9800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3848
    Cell Significance Index: -4.1100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3859
    Cell Significance Index: -4.2700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3902
    Cell Significance Index: -4.3400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3940
    Cell Significance Index: -4.3100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3969
    Cell Significance Index: -3.8100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3990
    Cell Significance Index: -4.2900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3995
    Cell Significance Index: -4.1100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.3997
    Cell Significance Index: -4.4400
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.3999
    Cell Significance Index: -4.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4033
    Cell Significance Index: -4.1600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4038
    Cell Significance Index: -4.1000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.4046
    Cell Significance Index: -4.1300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4062
    Cell Significance Index: -4.3400
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4065
    Cell Significance Index: -4.0100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4095
    Cell Significance Index: -4.3500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.4159
    Cell Significance Index: -4.3100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4184
    Cell Significance Index: -5.4900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4209
    Cell Significance Index: -4.8900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4230
    Cell Significance Index: -4.1300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.4263
    Cell Significance Index: -4.8900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4274
    Cell Significance Index: -5.0800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4278
    Cell Significance Index: -3.9700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4287
    Cell Significance Index: -4.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4299
    Cell Significance Index: -5.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4339
    Cell Significance Index: -4.1700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4359
    Cell Significance Index: -4.1300
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4392
    Cell Significance Index: -3.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4399
    Cell Significance Index: -4.1300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.4399
    Cell Significance Index: -4.3400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4418
    Cell Significance Index: -4.7000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4422
    Cell Significance Index: -4.3100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4465
    Cell Significance Index: -4.1600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4471
    Cell Significance Index: -4.5600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4491
    Cell Significance Index: -5.9100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.4503
    Cell Significance Index: -4.1600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4535
    Cell Significance Index: -4.1200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4543
    Cell Significance Index: -4.9500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4544
    Cell Significance Index: -4.9000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4584
    Cell Significance Index: -4.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Chain:** The IGHV1-24 gene is part of the heavy chain of immunoglobulins, which is composed of four polypeptide chains: alpha (α), delta (δ), epsilon (ε), and gamma (γ). The heavy chain is responsible for the binding of antigens to the antibody. 2. **Variable Region:** The IGHV1-24 gene encodes for the variable region of the heavy chain, which is responsible for the recognition of specific antigens. 3. **Diversity:** The IGHV1-24 gene is part of the diverse region of the heavy chain, which allows for the generation of a vast repertoire of antibodies with unique specificities. 4. **Expression:** The IGHV1-24 gene is significantly expressed in various cell types, including double-negative thymocytes, granulocyte-monocyte progenitor cells, and goblet cells. **Pathways and Functions:** 1. **Antigen Binding:** The IGHV1-24 gene plays a critical role in the binding of antigens to antibodies, which is essential for the recognition and neutralization of pathogens. 2. **Immunoglobulin Complex Formation:** The IGHV1-24 gene is involved in the formation of immunoglobulin complexes, which are essential for the activation of immune cells and the production of antibodies. 3. **Immunoglobulin Mediated Immune Response:** The IGHV1-24 gene is involved in the immunoglobulin-mediated immune response, which is essential for the recognition and neutralization of pathogens. 4. **Plasma Membrane:** The IGHV1-24 gene is localized on the plasma membrane, where it plays a critical role in the recognition and binding of antigens. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGHV1-24 gene can lead to immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), which is characterized by a deficiency in antibody production. 2. **Cancer:** The IGHV1-24 gene is overexpressed in certain types of cancer, such as follicular lymphoma, where it contributes to the development and progression of the disease. 3. **Autoimmune Diseases:** The IGHV1-24 gene is involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, where it contributes to the production of autoantibodies. 4. **Vaccine Development:** The IGHV1-24 gene is an important target for vaccine development, as it can be used to generate antibodies against specific pathogens. In conclusion, the IGHV1-24 gene is a critical component of the human immune system, and its dysregulation can lead to various immunodeficiency disorders, cancers, and autoimmune diseases. Further research is necessary to fully understand the role of the IGHV1-24 gene in the immune system and its potential applications in vaccine development and immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.