Details for: IGHJ6

Gene ID: 28475

Symbol: IGHJ6

Ensembl ID: ENSG00000211900

Description: immunoglobulin heavy joining 6

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9813
    Cell Significance Index: 23.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2641
    Cell Significance Index: 3.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2553
    Cell Significance Index: 3.3500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0251
    Cell Significance Index: -0.6400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0269
    Cell Significance Index: -0.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0270
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0336
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0354
    Cell Significance Index: -0.4700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0395
    Cell Significance Index: -0.3900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0498
    Cell Significance Index: -0.5100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0521
    Cell Significance Index: -0.4300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0529
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0530
    Cell Significance Index: -0.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0568
    Cell Significance Index: -1.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0586
    Cell Significance Index: -0.6600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0587
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0599
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0627
    Cell Significance Index: -0.6800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0644
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0654
    Cell Significance Index: -1.7800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0682
    Cell Significance Index: -0.8900
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0690
    Cell Significance Index: -0.7100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0722
    Cell Significance Index: -0.7600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0726
    Cell Significance Index: -0.7400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0737
    Cell Significance Index: -0.9700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0747
    Cell Significance Index: -0.9000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0767
    Cell Significance Index: -0.6300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0799
    Cell Significance Index: -0.9200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0810
    Cell Significance Index: -1.0300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0811
    Cell Significance Index: -0.8600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0817
    Cell Significance Index: -0.8900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0821
    Cell Significance Index: -0.9700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0840
    Cell Significance Index: -0.7100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0853
    Cell Significance Index: -0.9900
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0859
    Cell Significance Index: -0.7400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0875
    Cell Significance Index: -0.8000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0880
    Cell Significance Index: -1.0400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0881
    Cell Significance Index: -0.8000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0900
    Cell Significance Index: -0.9200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0901
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0907
    Cell Significance Index: -0.9200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0909
    Cell Significance Index: -1.1500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0921
    Cell Significance Index: -0.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0930
    Cell Significance Index: -1.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0931
    Cell Significance Index: -1.0800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0933
    Cell Significance Index: -0.9200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0948
    Cell Significance Index: -1.0500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0970
    Cell Significance Index: -0.9000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0975
    Cell Significance Index: -1.0800
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.0988
    Cell Significance Index: -0.9200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0992
    Cell Significance Index: -0.9900
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0992
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0993
    Cell Significance Index: -1.2200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1004
    Cell Significance Index: -1.0400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1018
    Cell Significance Index: -1.0400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1043
    Cell Significance Index: -1.0700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1062
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1089
    Cell Significance Index: -1.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1099
    Cell Significance Index: -1.1100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1104
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1107
    Cell Significance Index: -1.0500
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1110
    Cell Significance Index: -1.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1124
    Cell Significance Index: -1.3300
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1125
    Cell Significance Index: -0.9900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1148
    Cell Significance Index: -0.9300
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1151
    Cell Significance Index: -1.3200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1151
    Cell Significance Index: -1.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1157
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1160
    Cell Significance Index: -1.1200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1164
    Cell Significance Index: -1.0400
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1166
    Cell Significance Index: -1.0400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1170
    Cell Significance Index: -2.9200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1176
    Cell Significance Index: -1.0600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1183
    Cell Significance Index: -0.9200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1192
    Cell Significance Index: -1.0500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1200
    Cell Significance Index: -1.0500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1215
    Cell Significance Index: -1.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1225
    Cell Significance Index: -1.1500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1237
    Cell Significance Index: -1.3000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1238
    Cell Significance Index: -1.0500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1245
    Cell Significance Index: -1.0300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1250
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1261
    Cell Significance Index: -1.3300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1272
    Cell Significance Index: -1.2400
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1276
    Cell Significance Index: -0.9800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1286
    Cell Significance Index: -1.1100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1326
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1381
    Cell Significance Index: -1.5700
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.1386
    Cell Significance Index: -1.0500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1427
    Cell Significance Index: -1.0300
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.1441
    Cell Significance Index: -1.2200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1512
    Cell Significance Index: -1.8700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1531
    Cell Significance Index: -0.9500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1628
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Joining Gene:** IGHJ6 belongs to the immunoglobulin heavy joining gene family, which plays a crucial role in the assembly and diversity of the antibody repertoire. 2. **Widespread Tissue Expression:** IGHJ6 is significantly expressed in various cell types, including leukocytes, hematopoietic cells, and intestinal epithelial cells, indicating its involvement in multiple physiological processes. 3. **Cell Type-Specific Expression:** The expression of IGHJ6 is observed in specific cell types, such as IgG plasmablasts, goblet cells, absorptive cells, intestinal crypt stem cells, and transit amplifying cells, suggesting a cell-type-specific function. **Pathways and Functions:** 1. **Immunoglobulin Assembly and Diversity:** IGHJ6 likely participates in the assembly of the immunoglobulin heavy chain, contributing to the diversity of the antibody repertoire and the immune response. 2. **Intestinal Homeostasis:** The expression of IGHJ6 in intestinal epithelial cells and goblet cells suggests a role in maintaining intestinal homeostasis, including the regulation of immune responses and the protection against pathogens. 3. **Cell Signaling and Regulation:** IGHJ6 may also be involved in cell signaling and regulation, influencing the behavior of immune cells and epithelial cells in response to environmental cues. **Clinical Significance:** 1. **Immune System Dysregulation:** Abnormal expression or function of IGHJ6 may contribute to immune system dysregulation, leading to autoimmune diseases, allergies, or cancer. 2. **Intestinal Disorders:** The expression of IGHJ6 in intestinal epithelial cells and goblet cells suggests a link between IGHJ6 and intestinal disorders, such as inflammatory bowel disease (IBD) or celiac disease. 3. **Cancer Association:** The presence of IGHJ6 in various cell types, including hematopoietic cells and intestinal epithelial cells, raises the possibility of its involvement in cancer development and progression. In conclusion, IGHJ6 is a novel immunoglobulin heavy joining gene with significant implications for our understanding of the immune system and its regulation. Further research is necessary to elucidate the precise functions of IGHJ6 and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.