Details for: IGHJ4

Gene ID: 28477

Symbol: IGHJ4

Ensembl ID: ENSG00000240041

Description: immunoglobulin heavy joining 4

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leukocyte (CL0000738)
    Fold Change: 4.78
    Marker Score: 2,742
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,963
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,675
  • Cell Name: Unknown (CL0000003)
    Fold Change: 1.08
    Marker Score: 3,351
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.03
    Marker Score: 448
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 1
    Marker Score: 5,701
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,379
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,566
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,730
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,277
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.83
    Marker Score: 230
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 550
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.35
    Marker Score: 298
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.28
    Marker Score: 254
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.14
    Marker Score: 183
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 130
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.08
    Marker Score: 127
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 146
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 98
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ4 is a member of the immunoglobulin heavy chain family, which plays a crucial role in the adaptive immune response. The gene's unique expression profile, with significant presence in leukocytes and intestinal epithelial cells, suggests a specialized function that transcends traditional antibody production. Notably, IGHJ4's expression is also observed in stem cells and neoplastic cells, hinting at its involvement in cellular proliferation and differentiation. **Pathways and Functions:** The molecular mechanisms underlying IGHJ4's functions remain poorly understood. However, several signaling pathways are likely to be involved: 1. **Notch signaling:** The Notch pathway, crucial for cell fate determination and differentiation, may interact with IGHJ4 to regulate the development and maintenance of immune cells. 2. **Wnt/β-catenin signaling:** This pathway, involved in cell proliferation and differentiation, could also be influenced by IGHJ4, particularly in intestinal epithelial cells. 3. **JAK/STAT signaling:** The JAK/STAT pathway, critical for cytokine signaling and immune response, may be modulated by IGHJ4, influencing the function of immune cells. IGHJ4's functional implications are multifaceted: * **Immune cell development:** IGHJ4 may contribute to the development and maturation of immune cells, such as B cells and T cells. * **Intestinal homeostasis:** The gene's expression in intestinal epithelial cells could play a role in maintaining the delicate balance between the immune system and the gut microbiome. * **Cancer development:** IGHJ4's presence in neoplastic cells suggests a potential role in tumorigenesis, possibly through its influence on cellular proliferation and differentiation. **Clinical Significance:** The clinical relevance of IGHJ4 is an area of active research. While its expression in cancer cells is intriguing, further studies are needed to determine whether IGHJ4 serves as a biomarker for cancer diagnosis or treatment. Additionally, the gene's role in immune-related disorders, such as autoimmune diseases or immunodeficiencies, warrants investigation. In conclusion, IGHJ4 is a gene of great interest, with far-reaching implications for our understanding of the immune system and its role in disease. Further research is necessary to elucidate the molecular mechanisms underlying IGHJ4's functions and to explore its potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.