IGHJ4 | ENSG00000240041 | NCBI 28477

Details for: IGHJ4

Gene ID: 28477

Symbol: IGHJ4

Ensembl ID: ENSG00000240041

Description: immunoglobulin heavy joining 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.3677
Cell Significance Index: 5.3600
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.0149
Cell Significance Index: 0.1200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0097
Cell Significance Index: -0.4500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0109
Cell Significance Index: -0.1900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0220
Cell Significance Index: -0.4300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0223
Cell Significance Index: -0.5400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0265
Cell Significance Index: -0.7200
Cell Name: ionocyte (CL0005006)
Fold Change: -0.0406
Cell Significance Index: -0.4200
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.0412
Cell Significance Index: -0.3400
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0424
Cell Significance Index: -0.5800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0485
Cell Significance Index: -1.2400
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0510
Cell Significance Index: -0.5700
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0644
Cell Significance Index: -0.8500
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0700
Cell Significance Index: -1.7500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0725
Cell Significance Index: -1.3400
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.0764
Cell Significance Index: -0.8700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0826
Cell Significance Index: -1.0800
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0834
Cell Significance Index: -1.3500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0856
Cell Significance Index: -0.5700
Cell Name: secretory cell (CL0000151)
Fold Change: -0.0886
Cell Significance Index: -0.6100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0906
Cell Significance Index: -1.5500
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.0951
Cell Significance Index: -0.9900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0993
Cell Significance Index: -1.3200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0994
Cell Significance Index: -1.2600
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.1005
Cell Significance Index: -1.3000
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.1016
Cell Significance Index: -1.0300
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1034
Cell Significance Index: -1.3500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.1045
Cell Significance Index: -1.1000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1047
Cell Significance Index: -1.1900
Cell Name: mast cell (CL0000097)
Fold Change: -0.1052
Cell Significance Index: -1.3900
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1056
Cell Significance Index: -1.2000
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.1060
Cell Significance Index: -1.2000
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.1065
Cell Significance Index: -1.1500
Cell Name: B cell (CL0000236)
Fold Change: -0.1066
Cell Significance Index: -1.2600
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1090
Cell Significance Index: -1.4000
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.1122
Cell Significance Index: -1.2000
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1125
Cell Significance Index: -1.2100
Cell Name: memory B cell (CL0000787)
Fold Change: -0.1133
Cell Significance Index: -1.2100
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1155
Cell Significance Index: -1.3400
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.1157
Cell Significance Index: -1.1800
Cell Name: fibroblast (CL0000057)
Fold Change: -0.1161
Cell Significance Index: -1.0900
Cell Name: platelet (CL0000233)
Fold Change: -0.1171
Cell Significance Index: -1.2100
Cell Name: monocyte (CL0000576)
Fold Change: -0.1173
Cell Significance Index: -1.3500
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1181
Cell Significance Index: -1.0800
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1186
Cell Significance Index: -1.0100
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.1219
Cell Significance Index: -1.3500
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1219
Cell Significance Index: -1.4400
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1237
Cell Significance Index: -1.5200
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1242
Cell Significance Index: -1.3100
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.1249
Cell Significance Index: -1.4500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.1271
Cell Significance Index: -1.3500
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.1278
Cell Significance Index: -1.4200
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1292
Cell Significance Index: -1.3400
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.1293
Cell Significance Index: -1.3400
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1295
Cell Significance Index: -1.2500
Cell Name: plasmablast (CL0000980)
Fold Change: -0.1304
Cell Significance Index: -1.2100
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.1304
Cell Significance Index: -0.8100
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.1312
Cell Significance Index: -1.5100
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: -0.1313
Cell Significance Index: -1.2200
Cell Name: naive T cell (CL0000898)
Fold Change: -0.1321
Cell Significance Index: -1.2000
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1321
Cell Significance Index: -1.3500
Cell Name: macrophage (CL0000235)
Fold Change: -0.1322
Cell Significance Index: -1.3500
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.1340
Cell Significance Index: -1.3500
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.1353
Cell Significance Index: -1.3500
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.1360
Cell Significance Index: -1.3800
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.1363
Cell Significance Index: -1.4500
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.1368
Cell Significance Index: -1.3500
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.1368
Cell Significance Index: -1.2000
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1386
Cell Significance Index: -1.4000
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: -0.1399
Cell Significance Index: -1.4400
Cell Name: immature B cell (CL0000816)
Fold Change: -0.1406
Cell Significance Index: -1.3300
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1421
Cell Significance Index: -1.5100
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.1424
Cell Significance Index: -1.3500
Cell Name: myelocyte (CL0002193)
Fold Change: -0.1425
Cell Significance Index: -1.5200
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1450
Cell Significance Index: -1.3500
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.1480
Cell Significance Index: -1.3200
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.1489
Cell Significance Index: -1.3300
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.1505
Cell Significance Index: -1.2200
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.1513
Cell Significance Index: -1.4000
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.1516
Cell Significance Index: -1.3500
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: -0.1532
Cell Significance Index: -1.2500
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.1539
Cell Significance Index: -1.4400
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1555
Cell Significance Index: -1.3700
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: -0.1564
Cell Significance Index: -1.3200
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.1565
Cell Significance Index: -1.3500
Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.1595
Cell Significance Index: -1.3000
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.1633
Cell Significance Index: -1.3400
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.1723
Cell Significance Index: -1.5700
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.1735
Cell Significance Index: -1.3500
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.1744
Cell Significance Index: -1.4700
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.1751
Cell Significance Index: -1.4800
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1753
Cell Significance Index: -1.5800
Cell Name: IgM plasma cell (CL0000986)
Fold Change: -0.1758
Cell Significance Index: -1.3500
Cell Name: T cell (CL0000084)
Fold Change: -0.1760
Cell Significance Index: -2.0800
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.1815
Cell Significance Index: -1.3500
Cell Name: pericyte (CL0000669)
Fold Change: -0.1854
Cell Significance Index: -2.2200
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1862
Cell Significance Index: -2.3300
Cell Name: enterocyte (CL0000584)
Fold Change: -0.2055
Cell Significance Index: -1.2800
Cell Name: mature B cell (CL0000785)
Fold Change: -0.2059
Cell Significance Index: -1.3400
Cell Name: malignant cell (CL0001064)
Fold Change: -0.2064
Cell Significance Index: -1.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** IGHJ4 is a member of the immunoglobulin heavy chain family, which plays a crucial role in the adaptive immune response. The gene's unique expression profile, with significant presence in leukocytes and intestinal epithelial cells, suggests a specialized function that transcends traditional antibody production. Notably, IGHJ4's expression is also observed in stem cells and neoplastic cells, hinting at its involvement in cellular proliferation and differentiation. **Pathways and Functions:** The molecular mechanisms underlying IGHJ4's functions remain poorly understood. However, several signaling pathways are likely to be involved: 1. **Notch signaling:** The Notch pathway, crucial for cell fate determination and differentiation, may interact with IGHJ4 to regulate the development and maintenance of immune cells. 2. **Wnt/β-catenin signaling:** This pathway, involved in cell proliferation and differentiation, could also be influenced by IGHJ4, particularly in intestinal epithelial cells. 3. **JAK/STAT signaling:** The JAK/STAT pathway, critical for cytokine signaling and immune response, may be modulated by IGHJ4, influencing the function of immune cells. IGHJ4's functional implications are multifaceted: * **Immune cell development:** IGHJ4 may contribute to the development and maturation of immune cells, such as B cells and T cells. * **Intestinal homeostasis:** The gene's expression in intestinal epithelial cells could play a role in maintaining the delicate balance between the immune system and the gut microbiome. * **Cancer development:** IGHJ4's presence in neoplastic cells suggests a potential role in tumorigenesis, possibly through its influence on cellular proliferation and differentiation. **Clinical Significance:** The clinical relevance of IGHJ4 is an area of active research. While its expression in cancer cells is intriguing, further studies are needed to determine whether IGHJ4 serves as a biomarker for cancer diagnosis or treatment. Additionally, the gene's role in immune-related disorders, such as autoimmune diseases or immunodeficiencies, warrants investigation. In conclusion, IGHJ4 is a gene of great interest, with far-reaching implications for our understanding of the immune system and its role in disease. Further research is necessary to elucidate the molecular mechanisms underlying IGHJ4's functions and to explore its potential clinical applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.