Details for: TRDV3

Gene ID: 28516

Symbol: TRDV3

Ensembl ID: ENSG00000256590

Description: T cell receptor delta variable 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,089
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 7.6
    Marker Score: 48,979
  • Cell Name: macrophage (CL0000235)
    Fold Change: 7.53
    Marker Score: 8,373
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,281
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,847
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,179
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,062
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 294
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.3
    Marker Score: 202
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 140
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.16
    Marker Score: 216
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.15
    Marker Score: 224
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.13
    Marker Score: 412
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.12
    Marker Score: 133
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.12
    Marker Score: 101
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.12
    Marker Score: 284
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.12
    Marker Score: 102
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 257
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 128
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 132
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.06
    Marker Score: 88
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 108
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 35
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 489
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 106
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.01
    Marker Score: 38
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.01
    Marker Score: 10

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDV3 is a single-copy gene with a relatively low expression level, but its impact on the immune system is significant. The gene is part of the TCR complex, which is composed of multiple subunits that interact to form a functional receptor. TRDV3 is specifically involved in the assembly and maturation of the TCR complex, particularly in the early stages of T cell development. Its expression is restricted to a subset of immune cells, including T cells, macrophages, and microglial cells, which are key players in the innate and adaptive immune responses. **Pathways and Functions:** TRDV3 is involved in several key pathways, including: 1. **Adaptive Immune Response:** TRDV3 plays a crucial role in the assembly and maturation of the TCR complex, which is essential for recognizing and responding to antigens. 2. **Innate Immune Response:** TRDV3 is also expressed in innate immune cells, such as macrophages and microglial cells, which are critical for the initial defense against pathogens. 3. **Immunoglobulin Production:** TRDV3 is involved in the regulation of immunoglobulin production, which is essential for the elimination of pathogens. 4. **Cell Signaling:** TRDV3 is a key component of the TCR signaling pathway, which is essential for the activation of T cells. **Clinical Significance:** TRDV3 mutations or variations have been associated with several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes (T1D). These diseases are characterized by an imbalanced immune response, which can lead to tissue damage and dysfunction. Understanding the role of TRDV3 in the immune system can provide valuable insights into the pathogenesis of these diseases and may lead to the development of novel therapeutic strategies. Furthermore, TRDV3 has been implicated in the regulation of the blood-brain barrier, which is critical for maintaining the integrity of the central nervous system. Alterations in TRDV3 expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRDV3 is a crucial gene that plays a significant role in the adaptive and innate immune responses. Its dysregulation has been implicated in several autoimmune diseases and neurodegenerative disorders, highlighting the need for further research into the mechanisms underlying its function and the development of novel therapeutic strategies. **Recommendations:** 1. Further research is needed to fully understand the mechanisms underlying TRDV3 function and its role in autoimmune diseases and neurodegenerative disorders. 2. The development of novel therapeutic strategies targeting TRDV3 may provide new avenues for the treatment of autoimmune diseases and neurodegenerative disorders. 3. The study of TRDV3 expression in various cell types and tissues may provide insights into its role in maintaining tissue homeostasis and preventing disease. By continuing to explore the role of TRDV3 in the immune system, we may uncover new insights into the mechanisms underlying autoimmune diseases and neurodegenerative disorders, ultimately leading to the development of more effective therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.