Details for: TRDV3

Gene ID: 28516

Symbol: TRDV3

Ensembl ID: ENSG00000256590

Description: T cell receptor delta variable 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 2.1169
    Cell Significance Index: -0.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4774
    Cell Significance Index: 5.3400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1692
    Cell Significance Index: 2.0000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1045
    Cell Significance Index: 0.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0777
    Cell Significance Index: 1.0700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0750
    Cell Significance Index: 0.8900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0504
    Cell Significance Index: 0.6300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0129
    Cell Significance Index: 0.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0043
    Cell Significance Index: 0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0019
    Cell Significance Index: 0.1900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -1.0100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0169
    Cell Significance Index: -0.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0190
    Cell Significance Index: -0.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0209
    Cell Significance Index: -0.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0274
    Cell Significance Index: -0.7000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0279
    Cell Significance Index: -0.3000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0308
    Cell Significance Index: -0.9800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0311
    Cell Significance Index: -0.3700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0318
    Cell Significance Index: -0.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0319
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0335
    Cell Significance Index: -0.9600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0352
    Cell Significance Index: -0.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0358
    Cell Significance Index: -0.5100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0361
    Cell Significance Index: -0.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0365
    Cell Significance Index: -0.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0407
    Cell Significance Index: -0.4800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0421
    Cell Significance Index: -0.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0435
    Cell Significance Index: -0.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0446
    Cell Significance Index: -0.8700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0448
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0460
    Cell Significance Index: -0.4300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0463
    Cell Significance Index: -0.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0470
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0481
    Cell Significance Index: -0.9400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0493
    Cell Significance Index: -0.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0494
    Cell Significance Index: -0.7300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0506
    Cell Significance Index: -0.5700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0508
    Cell Significance Index: -0.4800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0510
    Cell Significance Index: -0.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0512
    Cell Significance Index: -0.7100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0512
    Cell Significance Index: -0.6800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0527
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0541
    Cell Significance Index: -1.0000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0554
    Cell Significance Index: -0.7100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0562
    Cell Significance Index: -0.9600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0578
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0579
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0581
    Cell Significance Index: -0.5900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0593
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0594
    Cell Significance Index: -0.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0595
    Cell Significance Index: -0.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0597
    Cell Significance Index: -0.6500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0605
    Cell Significance Index: -0.7300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0607
    Cell Significance Index: -0.7800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0612
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0614
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0626
    Cell Significance Index: -0.6600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0629
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0633
    Cell Significance Index: -0.6000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0633
    Cell Significance Index: -0.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0636
    Cell Significance Index: -0.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0644
    Cell Significance Index: -0.7700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0646
    Cell Significance Index: -0.5500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0650
    Cell Significance Index: -0.7800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0665
    Cell Significance Index: -0.7200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0667
    Cell Significance Index: -0.7300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0668
    Cell Significance Index: -0.7400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0669
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0671
    Cell Significance Index: -0.6300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0672
    Cell Significance Index: -0.7200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0676
    Cell Significance Index: -0.6900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0678
    Cell Significance Index: -0.6100
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0700
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0701
    Cell Significance Index: -0.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0702
    Cell Significance Index: -0.5900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0708
    Cell Significance Index: -0.7300
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0709
    Cell Significance Index: -0.7300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0716
    Cell Significance Index: -0.8300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0716
    Cell Significance Index: -0.7300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0730
    Cell Significance Index: -0.7400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0735
    Cell Significance Index: -0.9600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0736
    Cell Significance Index: -0.9100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0740
    Cell Significance Index: -0.7300
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0744
    Cell Significance Index: -0.6900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0747
    Cell Significance Index: -0.7300
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0750
    Cell Significance Index: -0.5200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0750
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0752
    Cell Significance Index: -0.7800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0753
    Cell Significance Index: -0.8900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0763
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0774
    Cell Significance Index: -0.9200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0782
    Cell Significance Index: -0.9000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0782
    Cell Significance Index: -0.8200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0787
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRDV3 is a single-copy gene with a relatively low expression level, but its impact on the immune system is significant. The gene is part of the TCR complex, which is composed of multiple subunits that interact to form a functional receptor. TRDV3 is specifically involved in the assembly and maturation of the TCR complex, particularly in the early stages of T cell development. Its expression is restricted to a subset of immune cells, including T cells, macrophages, and microglial cells, which are key players in the innate and adaptive immune responses. **Pathways and Functions:** TRDV3 is involved in several key pathways, including: 1. **Adaptive Immune Response:** TRDV3 plays a crucial role in the assembly and maturation of the TCR complex, which is essential for recognizing and responding to antigens. 2. **Innate Immune Response:** TRDV3 is also expressed in innate immune cells, such as macrophages and microglial cells, which are critical for the initial defense against pathogens. 3. **Immunoglobulin Production:** TRDV3 is involved in the regulation of immunoglobulin production, which is essential for the elimination of pathogens. 4. **Cell Signaling:** TRDV3 is a key component of the TCR signaling pathway, which is essential for the activation of T cells. **Clinical Significance:** TRDV3 mutations or variations have been associated with several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes (T1D). These diseases are characterized by an imbalanced immune response, which can lead to tissue damage and dysfunction. Understanding the role of TRDV3 in the immune system can provide valuable insights into the pathogenesis of these diseases and may lead to the development of novel therapeutic strategies. Furthermore, TRDV3 has been implicated in the regulation of the blood-brain barrier, which is critical for maintaining the integrity of the central nervous system. Alterations in TRDV3 expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, TRDV3 is a crucial gene that plays a significant role in the adaptive and innate immune responses. Its dysregulation has been implicated in several autoimmune diseases and neurodegenerative disorders, highlighting the need for further research into the mechanisms underlying its function and the development of novel therapeutic strategies. **Recommendations:** 1. Further research is needed to fully understand the mechanisms underlying TRDV3 function and its role in autoimmune diseases and neurodegenerative disorders. 2. The development of novel therapeutic strategies targeting TRDV3 may provide new avenues for the treatment of autoimmune diseases and neurodegenerative disorders. 3. The study of TRDV3 expression in various cell types and tissues may provide insights into its role in maintaining tissue homeostasis and preventing disease. By continuing to explore the role of TRDV3 in the immune system, we may uncover new insights into the mechanisms underlying autoimmune diseases and neurodegenerative disorders, ultimately leading to the development of more effective therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.