Details for: TRBV21 1

Gene ID: 28566

Symbol: TRBV21 1

Ensembl ID: ENSG00000251578

Description: T cell receptor beta variable 21-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4059
    Cell Significance Index: 4.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.3342
    Cell Significance Index: 4.5900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3219
    Cell Significance Index: 1.7600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2487
    Cell Significance Index: 2.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0093
    Cell Significance Index: -1.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0133
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0341
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0345
    Cell Significance Index: -1.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0392
    Cell Significance Index: -0.9500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0411
    Cell Significance Index: -0.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0432
    Cell Significance Index: -1.1600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0483
    Cell Significance Index: -0.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0550
    Cell Significance Index: -1.5000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0551
    Cell Significance Index: -0.6500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0573
    Cell Significance Index: -0.7800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0583
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0663
    Cell Significance Index: -0.8000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0727
    Cell Significance Index: -1.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0744
    Cell Significance Index: -1.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0784
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0789
    Cell Significance Index: -1.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0790
    Cell Significance Index: -1.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0793
    Cell Significance Index: -2.0200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0829
    Cell Significance Index: -1.0500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0833
    Cell Significance Index: -0.7100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0841
    Cell Significance Index: -1.0400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0846
    Cell Significance Index: -1.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0856
    Cell Significance Index: -1.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0881
    Cell Significance Index: -1.8700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0919
    Cell Significance Index: -0.8600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0932
    Cell Significance Index: -1.1300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0964
    Cell Significance Index: -1.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0997
    Cell Significance Index: -1.2600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1050
    Cell Significance Index: -0.8700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1052
    Cell Significance Index: -1.1200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1061
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1068
    Cell Significance Index: -1.3500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1079
    Cell Significance Index: -1.0900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1084
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1142
    Cell Significance Index: -2.1100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1144
    Cell Significance Index: -1.4800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1175
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1186
    Cell Significance Index: -1.1400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1193
    Cell Significance Index: -1.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1199
    Cell Significance Index: -2.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1208
    Cell Significance Index: -1.6800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1228
    Cell Significance Index: -1.3200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1238
    Cell Significance Index: -1.4700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1252
    Cell Significance Index: -1.0800
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1276
    Cell Significance Index: -1.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1282
    Cell Significance Index: -1.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1294
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1338
    Cell Significance Index: -1.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1351
    Cell Significance Index: -1.5900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1394
    Cell Significance Index: -1.4100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1401
    Cell Significance Index: -1.8000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1406
    Cell Significance Index: -1.8500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1413
    Cell Significance Index: -1.9800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1427
    Cell Significance Index: -1.6600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1434
    Cell Significance Index: -1.3600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1463
    Cell Significance Index: -1.9200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1486
    Cell Significance Index: -1.9400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1486
    Cell Significance Index: -1.7100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1488
    Cell Significance Index: -1.2800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1488
    Cell Significance Index: -1.7500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1521
    Cell Significance Index: -1.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1537
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1537
    Cell Significance Index: -1.2100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1555
    Cell Significance Index: -1.7900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1582
    Cell Significance Index: -1.8700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1584
    Cell Significance Index: -1.4500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1590
    Cell Significance Index: -2.1200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1609
    Cell Significance Index: -1.1200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1615
    Cell Significance Index: -1.8200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1620
    Cell Significance Index: -1.8400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1623
    Cell Significance Index: -2.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1625
    Cell Significance Index: -2.1600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1635
    Cell Significance Index: -1.3800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1638
    Cell Significance Index: -2.1100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1645
    Cell Significance Index: -1.4800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1646
    Cell Significance Index: -1.8000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1670
    Cell Significance Index: -1.9400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1674
    Cell Significance Index: -1.7000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1685
    Cell Significance Index: -1.8000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1688
    Cell Significance Index: -1.8200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1692
    Cell Significance Index: -2.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1697
    Cell Significance Index: -1.8400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1701
    Cell Significance Index: -2.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1724
    Cell Significance Index: -2.0800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1726
    Cell Significance Index: -1.9000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1729
    Cell Significance Index: -1.4000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1733
    Cell Significance Index: -1.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1753
    Cell Significance Index: -1.7500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1753
    Cell Significance Index: -1.7800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1759
    Cell Significance Index: -1.8300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1767
    Cell Significance Index: -1.8300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1772
    Cell Significance Index: -1.6400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1783
    Cell Significance Index: -1.8200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1790
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression profile:** TRBV21-1 is expressed in a wide range of hematopoietic cell types, including granulocyte-monocyte progenitor cells, early T lineage precursors, precursor B cells, neutrophil progenitors, neutrophils, common myeloid progenitors, megakaryocyte-erythroid progenitor cells, pro-B cells, and fraction A pre-pro B cells. 2. **Pseudogene status:** TRBV21-1 is classified as a pseudogene, meaning it lacks a functional coding sequence and does not produce a protein. 3. **Cellular specificity:** The expression of TRBV21-1 is highly specific to hematopoietic cells, suggesting a role in the development and regulation of the immune system. **Pathways and Functions:** 1. **T cell receptor signaling:** Although TRBV21-1 is a pseudogene, it may influence T cell receptor signaling through the modulation of T cell development and function. 2. **Hematopoiesis:** The expression of TRBV21-1 in early hematopoietic cells may play a role in regulating the development of various immune cell types. 3. **Immune tolerance:** TRBV21-1 may contribute to immune tolerance by influencing the development and function of regulatory T cells. **Clinical Significance:** 1. **Immunodeficiency disorders:** The expression of TRBV21-1 in precursor B cells and pro-B cells suggests a potential role in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia. 2. **Cancer:** The expression of TRBV21-1 in various hematopoietic cell types may be associated with cancer development and progression, particularly in leukemias and lymphomas. 3. **Autoimmune diseases:** The involvement of TRBV21-1 in immune tolerance mechanisms may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, the TRBV21-1 gene, despite its pseudogene status, holds significant promise for understanding the intricacies of T cell receptor beta variable regions and their role in the development and regulation of the immune system. Further research is necessary to elucidate the functional significance of TRBV21-1 and its implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.