Details for: TRBV13

Gene ID: 28574

Symbol: TRBV13

Ensembl ID: ENSG00000276405

Description: T cell receptor beta variable 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0899
    Cell Significance Index: 0.4900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.0507
    Cell Significance Index: 0.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0354
    Cell Significance Index: 0.4200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0246
    Cell Significance Index: 0.2800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.0060
    Cell Significance Index: 0.0400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0111
    Cell Significance Index: -0.0900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0250
    Cell Significance Index: -0.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0251
    Cell Significance Index: -0.4200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0271
    Cell Significance Index: -0.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0291
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0311
    Cell Significance Index: -0.9900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0320
    Cell Significance Index: -0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0337
    Cell Significance Index: -0.4000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0360
    Cell Significance Index: -0.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0366
    Cell Significance Index: -0.9800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0385
    Cell Significance Index: -0.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0395
    Cell Significance Index: -0.4300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0414
    Cell Significance Index: -0.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0415
    Cell Significance Index: -1.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0447
    Cell Significance Index: -0.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0450
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0452
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0455
    Cell Significance Index: -0.4600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0485
    Cell Significance Index: -0.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0509
    Cell Significance Index: -1.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0528
    Cell Significance Index: -1.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0532
    Cell Significance Index: -0.5400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0567
    Cell Significance Index: -0.5100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0570
    Cell Significance Index: -0.7200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0574
    Cell Significance Index: -0.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0585
    Cell Significance Index: -1.4900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0602
    Cell Significance Index: -0.7400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0605
    Cell Significance Index: -0.9800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0615
    Cell Significance Index: -0.6200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0616
    Cell Significance Index: -0.5300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0618
    Cell Significance Index: -0.4300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0629
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0656
    Cell Significance Index: -0.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0656
    Cell Significance Index: -0.8500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0672
    Cell Significance Index: -0.6100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0712
    Cell Significance Index: -0.8900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0713
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0716
    Cell Significance Index: -0.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0724
    Cell Significance Index: -1.4200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0727
    Cell Significance Index: -1.0600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0745
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0756
    Cell Significance Index: -1.1500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0760
    Cell Significance Index: -0.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0760
    Cell Significance Index: -1.2200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0774
    Cell Significance Index: -1.4300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0789
    Cell Significance Index: -0.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0802
    Cell Significance Index: -1.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0813
    Cell Significance Index: -0.6500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0819
    Cell Significance Index: -0.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0828
    Cell Significance Index: -1.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0837
    Cell Significance Index: -1.4300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0844
    Cell Significance Index: -0.7100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0851
    Cell Significance Index: -0.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0858
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0872
    Cell Significance Index: -0.9200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0872
    Cell Significance Index: -1.1400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0880
    Cell Significance Index: -1.0700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0892
    Cell Significance Index: -0.7700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0901
    Cell Significance Index: -1.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0926
    Cell Significance Index: -1.1100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0932
    Cell Significance Index: -1.0500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0933
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0944
    Cell Significance Index: -1.1400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0954
    Cell Significance Index: -1.1000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0991
    Cell Significance Index: -1.1400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0994
    Cell Significance Index: -0.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0999
    Cell Significance Index: -1.3700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1003
    Cell Significance Index: -0.7800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1006
    Cell Significance Index: -0.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1007
    Cell Significance Index: -1.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1011
    Cell Significance Index: -1.1300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1019
    Cell Significance Index: -1.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1029
    Cell Significance Index: -1.0500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1037
    Cell Significance Index: -1.1000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1044
    Cell Significance Index: -1.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1044
    Cell Significance Index: -0.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1052
    Cell Significance Index: -0.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1053
    Cell Significance Index: -1.0100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1054
    Cell Significance Index: -1.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1056
    Cell Significance Index: -1.1500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1059
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1061
    Cell Significance Index: -1.1800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1065
    Cell Significance Index: -1.0500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1082
    Cell Significance Index: -1.3900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1084
    Cell Significance Index: -0.9600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1092
    Cell Significance Index: -1.0900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1097
    Cell Significance Index: -1.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV13 is a member of the TCR beta variable region, which is responsible for recognizing and binding to specific antigens. The variable regions of the TCR are generated through somatic recombination during T cell development, resulting in a diverse repertoire of TCRs. TRBV13 is one of the 30 TCR beta variable regions, and its unique sequence is thought to contribute to the specificity and diversity of the TCR repertoire. The expression of TRBV13 is restricted to specific cell types, including alpha-beta T cells, effector CD8-positive T cells, and certain subsets of macrophages and granulocytes. **Pathways and Functions:** TRBV13 is part of the TCR complex, which is a crucial component of the adaptive immune response. The TCR complex interacts with major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs), allowing T cells to recognize and respond to specific antigens. The interaction between the TCR and MHC molecules triggers a signaling cascade that activates various downstream pathways, including the activation of transcription factors, such as NF-κB and AP-1. These pathways ultimately lead to the transcription of genes involved in T cell activation, proliferation, and differentiation. TRBV13 has been shown to play a role in modulating the immune response, particularly in the context of cancer and autoimmune diseases. The expression of TRBV13 has been found to be altered in various types of cancer, including colorectal cancer and multiple myeloma. This suggests that TRBV13 may contribute to the development and progression of these diseases. Additionally, TRBV13 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the TCR complex plays a key role in the immune response. **Clinical Significance:** The clinical significance of TRBV13 lies in its potential role in the development and progression of various diseases, including cancer and autoimmune disorders. Further research is needed to fully understand the mechanisms by which TRBV13 contributes to disease pathogenesis and to identify potential therapeutic targets. The expression of TRBV13 in specific cell types may also provide insights into the development of novel diagnostic biomarkers and therapeutic strategies. In conclusion, TRBV13 is a critical component of the TCR complex, which plays a central role in the adaptive immune response. The expression of TRBV13 is significantly restricted to specific cell types, and its unique sequence is thought to contribute to the specificity and diversity of the TCR repertoire. Further research is needed to elucidate the mechanisms by which TRBV13 modulates the immune response and to identify potential therapeutic targets for the treatment of various diseases. **Recommendations:** 1. Further research is needed to fully understand the mechanisms by which TRBV13 contributes to disease pathogenesis. 2. The expression of TRBV13 in specific cell types may provide insights into the development of novel diagnostic biomarkers and therapeutic strategies. 3. The TCR complex, including TRBV13, may serve as a target for the development of novel immunotherapies for the treatment of cancer and autoimmune disorders. **Future Directions:** 1. Investigate the expression of TRBV13 in various diseases, including cancer and autoimmune disorders. 2. Elucidate the mechanisms by which TRBV13 modulates the immune response. 3. Develop novel therapeutic strategies targeting the TCR complex, including TRBV13, for the treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.