Details for: TRBV7 7

Gene ID: 28591

Symbol: TRBV7 7

Ensembl ID: ENSG00000253291

Description: T cell receptor beta variable 7-7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,809
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,574
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,725
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.39
    Marker Score: 326
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.23
    Marker Score: 250
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.19
    Marker Score: 318
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.17
    Marker Score: 186
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 198
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.08
    Marker Score: 145
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.08
    Marker Score: 67
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 140
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 138
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 99
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.02
    Marker Score: 104
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 720
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 147
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.01
    Marker Score: 111
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 11

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV7-7 is a member of the TRBV family, which consists of over 40 genes that encode for the beta variable region of T cell receptors. The TRBV7-7 gene is characterized by its ability to generate a diverse repertoire of T cell receptors, which is essential for the recognition of a wide range of antigens. The gene is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, highlighting its broad tissue distribution. **Pathways and Functions:** TRBV7-7 is embedded within the T cell receptor complex, where it interacts with other components of the complex to form a functional T cell receptor (TCR). The TCR recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon binding, the TCR triggers a cascade of signaling events that lead to the activation of T cells, proliferation, and differentiation into effector cells. The TRBV7-7 gene is part of the adaptive immune response, which is a highly specific and targeted response to pathogens. The adaptive immune response involves the activation of T cells, which recognize and eliminate infected cells or produce cytokines that recruit immune cells to sites of infection. **Clinical Significance:** TRBV7-7 has significant implications in various clinical contexts, including: 1. **Inflammatory bowel disease (IBD):** The expression of TRBV7-7 in intestinal epithelial cells has been linked to the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. The gene's role in the recognition of commensal bacteria and the initiation of an adaptive immune response may contribute to the development of IBD. 2. **Cancer:** The expression of TRBV7-7 has been observed in various types of cancer, including colon, breast, and lung cancer. The gene's role in the recognition of tumor antigens and the activation of immune cells may contribute to the development of cancer. 3. **Autoimmune diseases:** The TRBV7-7 gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. The gene's role in the recognition of self-antigens and the activation of immune cells may contribute to the development of autoimmune diseases. In conclusion, the TRBV7-7 gene is a vital component of the adaptive immune system, playing a crucial role in the recognition and response to pathogens. Its expression in various cell types and its involvement in various clinical contexts highlight its significance in understanding immune responses and developing novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms by which TRBV7-7 contributes to immune responses and to identify its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.