Details for: TRBV7 7

Gene ID: 28591

Symbol: TRBV7 7

Ensembl ID: ENSG00000253291

Description: T cell receptor beta variable 7-7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1900
    Cell Significance Index: 2.7700
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: 0.0040
    Cell Significance Index: 0.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0018
    Cell Significance Index: -0.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0039
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0141
    Cell Significance Index: -0.3000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0211
    Cell Significance Index: -0.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0235
    Cell Significance Index: -0.2000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0253
    Cell Significance Index: -0.3300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0377
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0450
    Cell Significance Index: -0.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0450
    Cell Significance Index: -0.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0471
    Cell Significance Index: -1.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0485
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0518
    Cell Significance Index: -1.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0521
    Cell Significance Index: -0.5500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0531
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0599
    Cell Significance Index: -0.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0606
    Cell Significance Index: -1.1900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0636
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0644
    Cell Significance Index: -1.1900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0649
    Cell Significance Index: -0.7700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0653
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0692
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0696
    Cell Significance Index: -1.1900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0696
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0700
    Cell Significance Index: -0.7100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0737
    Cell Significance Index: -0.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0742
    Cell Significance Index: -0.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0745
    Cell Significance Index: -0.9400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0754
    Cell Significance Index: -0.9400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0772
    Cell Significance Index: -0.8700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0778
    Cell Significance Index: -0.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0784
    Cell Significance Index: -0.7900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0829
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0831
    Cell Significance Index: -0.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0838
    Cell Significance Index: -0.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0846
    Cell Significance Index: -0.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0851
    Cell Significance Index: -1.0200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0857
    Cell Significance Index: -1.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0859
    Cell Significance Index: -1.0900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0878
    Cell Significance Index: -1.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0883
    Cell Significance Index: -1.1600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0905
    Cell Significance Index: -0.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0910
    Cell Significance Index: -0.8800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0912
    Cell Significance Index: -0.9500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0931
    Cell Significance Index: -0.9500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0934
    Cell Significance Index: -0.9100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0942
    Cell Significance Index: -0.9400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0945
    Cell Significance Index: -0.7900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0949
    Cell Significance Index: -1.1500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0950
    Cell Significance Index: -1.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0959
    Cell Significance Index: -1.0200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0973
    Cell Significance Index: -0.9000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0978
    Cell Significance Index: -1.1800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0991
    Cell Significance Index: -0.9000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1000
    Cell Significance Index: -0.8800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1008
    Cell Significance Index: -1.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1015
    Cell Significance Index: -1.2000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1015
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1024
    Cell Significance Index: -0.9800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1025
    Cell Significance Index: -0.8300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1039
    Cell Significance Index: -1.1200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1052
    Cell Significance Index: -1.1700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1056
    Cell Significance Index: -1.1700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1064
    Cell Significance Index: -0.9200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1067
    Cell Significance Index: -0.8300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1090
    Cell Significance Index: -1.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1101
    Cell Significance Index: -1.2000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1102
    Cell Significance Index: -1.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1109
    Cell Significance Index: -0.9200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1112
    Cell Significance Index: -1.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1114
    Cell Significance Index: -1.1300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1130
    Cell Significance Index: -1.2000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1136
    Cell Significance Index: -0.9400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1137
    Cell Significance Index: -1.1700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1150
    Cell Significance Index: -0.9800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1153
    Cell Significance Index: -1.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1160
    Cell Significance Index: -0.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1178
    Cell Significance Index: -1.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1206
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1207
    Cell Significance Index: -0.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1222
    Cell Significance Index: -0.9400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1228
    Cell Significance Index: -1.2000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1232
    Cell Significance Index: -1.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1235
    Cell Significance Index: -1.1500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1241
    Cell Significance Index: -1.1200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1242
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1245
    Cell Significance Index: -1.1500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1252
    Cell Significance Index: -1.1200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1271
    Cell Significance Index: -1.1200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1282
    Cell Significance Index: -1.1900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1284
    Cell Significance Index: -0.9600
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1288
    Cell Significance Index: -1.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV7-7 is a member of the TRBV family, which consists of over 40 genes that encode for the beta variable region of T cell receptors. The TRBV7-7 gene is characterized by its ability to generate a diverse repertoire of T cell receptors, which is essential for the recognition of a wide range of antigens. The gene is expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, highlighting its broad tissue distribution. **Pathways and Functions:** TRBV7-7 is embedded within the T cell receptor complex, where it interacts with other components of the complex to form a functional T cell receptor (TCR). The TCR recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon binding, the TCR triggers a cascade of signaling events that lead to the activation of T cells, proliferation, and differentiation into effector cells. The TRBV7-7 gene is part of the adaptive immune response, which is a highly specific and targeted response to pathogens. The adaptive immune response involves the activation of T cells, which recognize and eliminate infected cells or produce cytokines that recruit immune cells to sites of infection. **Clinical Significance:** TRBV7-7 has significant implications in various clinical contexts, including: 1. **Inflammatory bowel disease (IBD):** The expression of TRBV7-7 in intestinal epithelial cells has been linked to the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. The gene's role in the recognition of commensal bacteria and the initiation of an adaptive immune response may contribute to the development of IBD. 2. **Cancer:** The expression of TRBV7-7 has been observed in various types of cancer, including colon, breast, and lung cancer. The gene's role in the recognition of tumor antigens and the activation of immune cells may contribute to the development of cancer. 3. **Autoimmune diseases:** The TRBV7-7 gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. The gene's role in the recognition of self-antigens and the activation of immune cells may contribute to the development of autoimmune diseases. In conclusion, the TRBV7-7 gene is a vital component of the adaptive immune system, playing a crucial role in the recognition and response to pathogens. Its expression in various cell types and its involvement in various clinical contexts highlight its significance in understanding immune responses and developing novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms by which TRBV7-7 contributes to immune responses and to identify its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.