Details for: TRBV6 6

Gene ID: 28601

Symbol: TRBV6 6

Ensembl ID: ENSG00000211724

Description: T cell receptor beta variable 6-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4456
    Cell Significance Index: 2.4300
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.4211
    Cell Significance Index: 3.4900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2350
    Cell Significance Index: 3.4300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.1103
    Cell Significance Index: 1.3100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.0756
    Cell Significance Index: 0.6800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0107
    Cell Significance Index: 0.1200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0157
    Cell Significance Index: -3.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0224
    Cell Significance Index: -0.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0272
    Cell Significance Index: -0.6600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0285
    Cell Significance Index: -0.3600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0305
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0327
    Cell Significance Index: -0.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0333
    Cell Significance Index: -0.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0369
    Cell Significance Index: -0.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0462
    Cell Significance Index: -1.1800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0476
    Cell Significance Index: -0.1500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0477
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0502
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0568
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0585
    Cell Significance Index: -0.5600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0658
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0664
    Cell Significance Index: -0.9100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0695
    Cell Significance Index: -0.8600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0698
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0718
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0777
    Cell Significance Index: -1.3400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0814
    Cell Significance Index: -0.5600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0817
    Cell Significance Index: -0.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0846
    Cell Significance Index: -2.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0868
    Cell Significance Index: -0.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0905
    Cell Significance Index: -0.9900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0960
    Cell Significance Index: -1.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0969
    Cell Significance Index: -1.5700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0973
    Cell Significance Index: -1.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0974
    Cell Significance Index: -1.0100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0974
    Cell Significance Index: -1.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0974
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1001
    Cell Significance Index: -1.1900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1029
    Cell Significance Index: -1.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1040
    Cell Significance Index: -1.0600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1057
    Cell Significance Index: -1.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1069
    Cell Significance Index: -2.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1082
    Cell Significance Index: -1.4200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1082
    Cell Significance Index: -1.3300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1085
    Cell Significance Index: -1.1500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1125
    Cell Significance Index: -1.4800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1168
    Cell Significance Index: -1.3600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1169
    Cell Significance Index: -0.8700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1175
    Cell Significance Index: -1.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1179
    Cell Significance Index: -1.7400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1191
    Cell Significance Index: -1.2000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1195
    Cell Significance Index: -1.0100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1203
    Cell Significance Index: -1.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1207
    Cell Significance Index: -2.2300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1233
    Cell Significance Index: -1.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1261
    Cell Significance Index: -1.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1293
    Cell Significance Index: -1.2600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1300
    Cell Significance Index: -1.0000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1301
    Cell Significance Index: -1.1900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1305
    Cell Significance Index: -1.4500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1334
    Cell Significance Index: -1.2300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1341
    Cell Significance Index: -1.2400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1359
    Cell Significance Index: -1.3300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1361
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1416
    Cell Significance Index: -2.4200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1460
    Cell Significance Index: -1.4800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1460
    Cell Significance Index: -1.6000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1475
    Cell Significance Index: -1.9000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1489
    Cell Significance Index: -1.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1498
    Cell Significance Index: -1.5800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1513
    Cell Significance Index: -1.7800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1517
    Cell Significance Index: -1.7500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1523
    Cell Significance Index: -1.7700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1526
    Cell Significance Index: -1.3300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1531
    Cell Significance Index: -1.1700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1533
    Cell Significance Index: -1.5300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1537
    Cell Significance Index: -1.8700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1538
    Cell Significance Index: -1.7700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1540
    Cell Significance Index: -2.0100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1557
    Cell Significance Index: -1.8400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1583
    Cell Significance Index: -1.6400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1607
    Cell Significance Index: -1.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1626
    Cell Significance Index: -1.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1642
    Cell Significance Index: -1.8500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1674
    Cell Significance Index: -1.8700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1679
    Cell Significance Index: -1.8600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1681
    Cell Significance Index: -1.0400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1693
    Cell Significance Index: -1.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1719
    Cell Significance Index: -2.4100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1728
    Cell Significance Index: -1.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1736
    Cell Significance Index: -1.6300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1744
    Cell Significance Index: -1.8800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1755
    Cell Significance Index: -1.9000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1766
    Cell Significance Index: -1.4900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1785
    Cell Significance Index: -2.1400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1793
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRBV6-6 is predominantly expressed in various immune cells, including granulocyte monocyte progenitor cells, early T lineage precursors, effector CD8-positive T cells, central memory CD4-positive T cells, and precursor B cells. 2. **Cell Type Specificity:** The expression of TRBV6-6 is cell-type specific, indicating its unique role in differentiating between various immune cells. 3. **Variable Region:** TRBV6-6 belongs to the variable region of the TCR, which is responsible for recognizing and binding to specific antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV6-6 plays a critical role in the adaptive immune response by recognizing and binding to specific antigens, leading to the activation of T cells. 2. **Cell Surface Receptor Signaling Pathway:** The TCR complex, which includes TRBV6-6, initiates signaling pathways that activate various downstream effectors, including transcription factors and kinases. 3. **Plasma Membrane and T Cell Receptor Complex:** TRBV6-6 is embedded in the plasma membrane and is part of the TCR complex, which is crucial for the recognition and binding to antigens. 4. **T Cell Receptor Complex:** The TCR complex, which includes TRBV6-6, is essential for the recognition and binding to specific antigens, leading to T cell activation and proliferation. **Clinical Significance:** The understanding of TRBV6-6's role in the immune system has significant implications for the development of immunotherapies and vaccine strategies. Dysregulation or aberrant expression of TRBV6-6 has been implicated in various autoimmune and inflammatory disorders, such as multiple sclerosis and rheumatoid arthritis. Furthermore, the study of TRBV6-6's role in the adaptive immune response may provide insights into the development of novel immunotherapies and cancer therapies. In conclusion, TRBV6-6 is a critical component of the adaptive immune system, playing a pivotal role in recognizing and binding to specific antigens. Its unique expression pattern, cell-type specificity, and involvement in various signaling pathways underscore its importance in the immune system. Elucidating the functional significance of TRBV6-6 will provide valuable insights into the development of novel immunotherapies and vaccine strategies, ultimately improving our understanding of the immune system and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.