Details for: TRBV6 6

Gene ID: 28601

Symbol: TRBV6 6

Ensembl ID: ENSG00000211724

Description: T cell receptor beta variable 6-6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.94
    Marker Score: 793
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.92
    Marker Score: 998
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 498
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 385
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 210
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.32
    Marker Score: 279
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.25
    Marker Score: 347
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.25
    Marker Score: 769
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.24
    Marker Score: 420
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.24
    Marker Score: 430
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.17
    Marker Score: 133
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.16
    Marker Score: 133
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.12
    Marker Score: 131
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.11
    Marker Score: 152
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.09
    Marker Score: 383
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.09
    Marker Score: 4,559
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.08
    Marker Score: 99
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.07
    Marker Score: 145
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 132
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.06
    Marker Score: 156
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.06
    Marker Score: 253
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 671
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.05
    Marker Score: 510
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.05
    Marker Score: 108
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 66
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.02
    Marker Score: 70
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 37
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 160
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0
    Marker Score: 20
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 14

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRBV6-6 is predominantly expressed in various immune cells, including granulocyte monocyte progenitor cells, early T lineage precursors, effector CD8-positive T cells, central memory CD4-positive T cells, and precursor B cells. 2. **Cell Type Specificity:** The expression of TRBV6-6 is cell-type specific, indicating its unique role in differentiating between various immune cells. 3. **Variable Region:** TRBV6-6 belongs to the variable region of the TCR, which is responsible for recognizing and binding to specific antigens. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV6-6 plays a critical role in the adaptive immune response by recognizing and binding to specific antigens, leading to the activation of T cells. 2. **Cell Surface Receptor Signaling Pathway:** The TCR complex, which includes TRBV6-6, initiates signaling pathways that activate various downstream effectors, including transcription factors and kinases. 3. **Plasma Membrane and T Cell Receptor Complex:** TRBV6-6 is embedded in the plasma membrane and is part of the TCR complex, which is crucial for the recognition and binding to antigens. 4. **T Cell Receptor Complex:** The TCR complex, which includes TRBV6-6, is essential for the recognition and binding to specific antigens, leading to T cell activation and proliferation. **Clinical Significance:** The understanding of TRBV6-6's role in the immune system has significant implications for the development of immunotherapies and vaccine strategies. Dysregulation or aberrant expression of TRBV6-6 has been implicated in various autoimmune and inflammatory disorders, such as multiple sclerosis and rheumatoid arthritis. Furthermore, the study of TRBV6-6's role in the adaptive immune response may provide insights into the development of novel immunotherapies and cancer therapies. In conclusion, TRBV6-6 is a critical component of the adaptive immune system, playing a pivotal role in recognizing and binding to specific antigens. Its unique expression pattern, cell-type specificity, and involvement in various signaling pathways underscore its importance in the immune system. Elucidating the functional significance of TRBV6-6 will provide valuable insights into the development of novel immunotherapies and vaccine strategies, ultimately improving our understanding of the immune system and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.