Details for: TRBV4 2

Gene ID: 28616

Symbol: TRBV4 2

Ensembl ID: ENSG00000211745

Description: T cell receptor beta variable 4-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3778
    Cell Significance Index: 2.0600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.2445
    Cell Significance Index: 2.2000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1900
    Cell Significance Index: 1.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0660
    Cell Significance Index: 0.9100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.0517
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0101
    Cell Significance Index: -2.0200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0162
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0306
    Cell Significance Index: -0.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0417
    Cell Significance Index: -1.1200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0430
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0432
    Cell Significance Index: -0.3500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0452
    Cell Significance Index: -0.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0479
    Cell Significance Index: -0.7000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0480
    Cell Significance Index: -0.3300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0716
    Cell Significance Index: -1.8300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0768
    Cell Significance Index: -0.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0804
    Cell Significance Index: -3.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0853
    Cell Significance Index: -0.8200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0878
    Cell Significance Index: -0.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0883
    Cell Significance Index: -2.2500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0919
    Cell Significance Index: -0.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0956
    Cell Significance Index: -0.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0961
    Cell Significance Index: -2.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0993
    Cell Significance Index: -1.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1016
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1050
    Cell Significance Index: -1.8100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1151
    Cell Significance Index: -1.4900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1169
    Cell Significance Index: -1.2400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1195
    Cell Significance Index: -1.3400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1197
    Cell Significance Index: -2.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1212
    Cell Significance Index: -2.3700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1218
    Cell Significance Index: -1.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1243
    Cell Significance Index: -1.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1260
    Cell Significance Index: -1.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1277
    Cell Significance Index: -2.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1281
    Cell Significance Index: -1.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1286
    Cell Significance Index: -2.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1319
    Cell Significance Index: -1.5300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1340
    Cell Significance Index: -1.1200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1343
    Cell Significance Index: -1.1500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1370
    Cell Significance Index: -1.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1379
    Cell Significance Index: -1.7400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1398
    Cell Significance Index: -1.1800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1404
    Cell Significance Index: -1.5100
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1411
    Cell Significance Index: -0.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1422
    Cell Significance Index: -2.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1445
    Cell Significance Index: -2.3400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1463
    Cell Significance Index: -1.6000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1480
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1481
    Cell Significance Index: -1.7600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1482
    Cell Significance Index: -1.9500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1487
    Cell Significance Index: -1.7500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1505
    Cell Significance Index: -1.5600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1523
    Cell Significance Index: -1.7400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1529
    Cell Significance Index: -1.7500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1565
    Cell Significance Index: -1.3500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1568
    Cell Significance Index: -1.5900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1573
    Cell Significance Index: -1.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1590
    Cell Significance Index: -2.6600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1593
    Cell Significance Index: -1.9900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1593
    Cell Significance Index: -1.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1594
    Cell Significance Index: -1.2400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1611
    Cell Significance Index: -1.9600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1617
    Cell Significance Index: -1.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1625
    Cell Significance Index: -1.7700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1625
    Cell Significance Index: -1.7700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1626
    Cell Significance Index: -1.7000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1648
    Cell Significance Index: -1.7500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1649
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1652
    Cell Significance Index: -2.0300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1656
    Cell Significance Index: -1.5300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1656
    Cell Significance Index: -1.7100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1670
    Cell Significance Index: -1.8000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1685
    Cell Significance Index: -2.0200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1734
    Cell Significance Index: -1.8800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1735
    Cell Significance Index: -1.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1758
    Cell Significance Index: -2.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1768
    Cell Significance Index: -2.3200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1773
    Cell Significance Index: -1.8000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1774
    Cell Significance Index: -1.8700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1798
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1801
    Cell Significance Index: -1.9000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1810
    Cell Significance Index: -2.0400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1815
    Cell Significance Index: -2.3700
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1816
    Cell Significance Index: -1.8000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1822
    Cell Significance Index: -2.3400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1825
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1834
    Cell Significance Index: -2.0400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1836
    Cell Significance Index: -2.1700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1836
    Cell Significance Index: -2.4400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1850
    Cell Significance Index: -1.8100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1870
    Cell Significance Index: -2.2200
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1879
    Cell Significance Index: -1.8400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1886
    Cell Significance Index: -2.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1886
    Cell Significance Index: -2.6800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1887
    Cell Significance Index: -2.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV4-2 is a beta-chain variable region gene, which is essential for the formation of the TCR complex. The TCR complex is composed of alpha and beta chains, which together recognize specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells. TRBV4-2 is specifically expressed in a subset of alpha-beta T cells, including effector CD8-positive T cells, central memory CD4-positive T cells, and early T lineage precursors. The gene is also expressed in other cell types, such as granulocytes, monocytes, and megakaryocytes, highlighting its broader role in the immune system. **Pathways and Functions:** TRBV4-2 is involved in the adaptive immune response, specifically in the recognition and elimination of pathogens. The TCR complex recognizes antigens presented by MHC molecules, triggering a signaling cascade that activates T cells. This cascade involves the activation of various kinases, including ZAP-70, LCK, and LAT, which phosphorylate and activate downstream signaling molecules. TRBV4-2 is also involved in the regulation of T cell activation, proliferation, and differentiation. The gene is transcriptionally regulated by the TCR signaling pathway, which involves the activation of transcription factors such as NFAT and NF-κB. **Clinical Significance:** Impaired function or altered expression of TRBV4-2 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. These disorders are characterized by the dysregulation of the adaptive immune response, leading to the production of autoantibodies and the destruction of self-antigens. Additionally, TRBV4-2 has been associated with cancer, particularly in the context of T cell-mediated immunity. Altered expression of TRBV4-2 has been observed in various types of cancer, including leukemia, lymphoma, and melanoma. Furthermore, TRBV4-2 has been implicated in the pathogenesis of infectious diseases, such as HIV and tuberculosis, where impaired T cell function contributes to disease progression. In conclusion, TRBV4-2 is a critical component of the adaptive immune system, playing a key role in the recognition and elimination of pathogens. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of understanding the function and regulation of TRBV4-2 in the context of human disease. Further research is needed to elucidate the mechanisms underlying TRBV4-2 function and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.