Details for: TRBJ2 1

Gene ID: 28629

Symbol: TRBJ2 1

Ensembl ID: ENSG00000211764

Description: T cell receptor beta joining 2-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4804
    Cell Significance Index: 35.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4707
    Cell Significance Index: 6.8600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2311
    Cell Significance Index: 1.2600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2130
    Cell Significance Index: 2.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1339
    Cell Significance Index: 1.4400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0645
    Cell Significance Index: 0.7000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0540
    Cell Significance Index: 0.7400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0501
    Cell Significance Index: 0.6300
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: 0.0020
    Cell Significance Index: 0.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0147
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0164
    Cell Significance Index: -0.2200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0168
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0173
    Cell Significance Index: -0.1600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0181
    Cell Significance Index: -0.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0216
    Cell Significance Index: -0.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0217
    Cell Significance Index: -0.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0259
    Cell Significance Index: -0.6600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0372
    Cell Significance Index: -0.4600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0380
    Cell Significance Index: -0.4800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0389
    Cell Significance Index: -0.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0396
    Cell Significance Index: -0.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0435
    Cell Significance Index: -0.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0449
    Cell Significance Index: -0.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0461
    Cell Significance Index: -0.5200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0532
    Cell Significance Index: -0.7000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0536
    Cell Significance Index: -0.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0543
    Cell Significance Index: -0.6900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0552
    Cell Significance Index: -0.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0585
    Cell Significance Index: -0.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0587
    Cell Significance Index: -0.7800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0591
    Cell Significance Index: -0.5100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0600
    Cell Significance Index: -0.6900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0604
    Cell Significance Index: -0.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0626
    Cell Significance Index: -0.7400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0643
    Cell Significance Index: -0.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0677
    Cell Significance Index: -0.8700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0681
    Cell Significance Index: -0.7500
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.0699
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0702
    Cell Significance Index: -0.7400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0705
    Cell Significance Index: -0.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0707
    Cell Significance Index: -0.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0713
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0718
    Cell Significance Index: -0.6900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0731
    Cell Significance Index: -0.6000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0734
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0742
    Cell Significance Index: -0.7500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0747
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0748
    Cell Significance Index: -0.9200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0771
    Cell Significance Index: -0.7000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0774
    Cell Significance Index: -0.7800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0777
    Cell Significance Index: -0.8600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0779
    Cell Significance Index: -0.7900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0791
    Cell Significance Index: -0.8400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0798
    Cell Significance Index: -0.8100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0802
    Cell Significance Index: -0.9300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0808
    Cell Significance Index: -0.8600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0823
    Cell Significance Index: -0.9200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0826
    Cell Significance Index: -0.7100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0830
    Cell Significance Index: -0.8600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0830
    Cell Significance Index: -0.8600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0861
    Cell Significance Index: -0.6700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0862
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0863
    Cell Significance Index: -0.8100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0865
    Cell Significance Index: -0.8000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0872
    Cell Significance Index: -0.8500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0887
    Cell Significance Index: -0.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0927
    Cell Significance Index: -1.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0929
    Cell Significance Index: -0.9900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0940
    Cell Significance Index: -0.9900
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0946
    Cell Significance Index: -0.9300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0967
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0976
    Cell Significance Index: -0.7900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0993
    Cell Significance Index: -0.8300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1012
    Cell Significance Index: -0.8900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1030
    Cell Significance Index: -0.9300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1054
    Cell Significance Index: -0.9400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1055
    Cell Significance Index: -0.8600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1067
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1072
    Cell Significance Index: -0.9900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1097
    Cell Significance Index: -0.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1098
    Cell Significance Index: -0.9600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1105
    Cell Significance Index: -0.7600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1123
    Cell Significance Index: -1.0000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1142
    Cell Significance Index: -0.8500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1159
    Cell Significance Index: -0.7400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1189
    Cell Significance Index: -0.9500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1317
    Cell Significance Index: -0.9100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1606
    Cell Significance Index: -0.8600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2428
    Cell Significance Index: -0.7400
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: -0.2459
    Cell Significance Index: -1.0100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.2755
    Cell Significance Index: -0.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ2 is a gene that codes for a protein involved in the assembly and function of the TCR complex. The TCR complex is composed of two chains: the alpha chain (TRAJ) and the beta chain (TRBJ). The beta chain is further divided into two exons, β1 and β2, which are joined by a joining region (TRBJ2). The TRBJ2 gene is expressed in various cell types, including those involved in the adaptive immune response. The expression of TRBJ2 is tightly regulated, and its dysregulation has been implicated in several immune-related disorders. **Pathways and Functions:** TRBJ2 plays a critical role in the adaptive immune response through its involvement in the TCR complex. The TCR complex recognizes specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon recognition, the TCR complex triggers a signaling cascade that activates T cells, leading to their proliferation, differentiation, and effector function. TRBJ2 is also involved in the regulation of immune responses, including the suppression of excessive immune reactions and the promotion of tolerance to self-antigens. Moreover, TRBJ2 has been implicated in the development of immune-related disorders, such as autoimmune diseases and cancer. **Clinical Significance:** The dysregulation of TRBJ2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases:** Dysregulation of TRBJ2 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the immune system mistakenly targets self-antigens. 2. **Cancer:** TRBJ2 has been implicated in the development of certain types of cancer, such as leukemia and lymphoma, where the immune system is compromised. 3. **Transplant rejection:** TRBJ2 has been shown to play a role in the rejection of transplanted organs, where the immune system recognizes the transplanted tissue as foreign. 4. **Immune tolerance:** TRBJ2 has been implicated in the regulation of immune tolerance, where the immune system learns to distinguish between self-antigens and non-self antigens. In conclusion, TRBJ2 is a critical gene involved in the adaptive immune response, and its dysregulation has significant implications for human health. Further research is needed to fully understand the role of TRBJ2 in immune regulation and its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.