Details for: TRBJ2 1

Gene ID: 28629

Symbol: TRBJ2 1

Ensembl ID: ENSG00000211764

Description: T cell receptor beta joining 2-1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1,513
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.69
    Marker Score: 1,610
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.1
    Marker Score: 1,427
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 209
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.22
    Marker Score: 187
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.18
    Marker Score: 293
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.16
    Marker Score: 282
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.14
    Marker Score: 156
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.13
    Marker Score: 118
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.12
    Marker Score: 363
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1
    Marker Score: 5,421
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 275
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 113
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.06
    Marker Score: 132
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.06
    Marker Score: 111
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 90
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.02
    Marker Score: 205
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 78
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ2 is a gene that codes for a protein involved in the assembly and function of the TCR complex. The TCR complex is composed of two chains: the alpha chain (TRAJ) and the beta chain (TRBJ). The beta chain is further divided into two exons, β1 and β2, which are joined by a joining region (TRBJ2). The TRBJ2 gene is expressed in various cell types, including those involved in the adaptive immune response. The expression of TRBJ2 is tightly regulated, and its dysregulation has been implicated in several immune-related disorders. **Pathways and Functions:** TRBJ2 plays a critical role in the adaptive immune response through its involvement in the TCR complex. The TCR complex recognizes specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). Upon recognition, the TCR complex triggers a signaling cascade that activates T cells, leading to their proliferation, differentiation, and effector function. TRBJ2 is also involved in the regulation of immune responses, including the suppression of excessive immune reactions and the promotion of tolerance to self-antigens. Moreover, TRBJ2 has been implicated in the development of immune-related disorders, such as autoimmune diseases and cancer. **Clinical Significance:** The dysregulation of TRBJ2 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases:** Dysregulation of TRBJ2 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the immune system mistakenly targets self-antigens. 2. **Cancer:** TRBJ2 has been implicated in the development of certain types of cancer, such as leukemia and lymphoma, where the immune system is compromised. 3. **Transplant rejection:** TRBJ2 has been shown to play a role in the rejection of transplanted organs, where the immune system recognizes the transplanted tissue as foreign. 4. **Immune tolerance:** TRBJ2 has been implicated in the regulation of immune tolerance, where the immune system learns to distinguish between self-antigens and non-self antigens. In conclusion, TRBJ2 is a critical gene involved in the adaptive immune response, and its dysregulation has significant implications for human health. Further research is needed to fully understand the role of TRBJ2 in immune regulation and its potential as a therapeutic target for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.