Details for: TRAV40

Gene ID: 28641

Symbol: TRAV40

Ensembl ID: ENSG00000211819

Description: T cell receptor alpha variable 40

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1632
    Cell Significance Index: 28.1800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.1251
    Cell Significance Index: 0.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0422
    Cell Significance Index: 0.2300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.0187
    Cell Significance Index: 0.1000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0170
    Cell Significance Index: 0.1900
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0006
    Cell Significance Index: -0.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0038
    Cell Significance Index: -0.1700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0055
    Cell Significance Index: -0.0800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0065
    Cell Significance Index: -0.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0078
    Cell Significance Index: -0.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0128
    Cell Significance Index: -0.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0131
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0148
    Cell Significance Index: -0.2400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0155
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0203
    Cell Significance Index: -0.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0206
    Cell Significance Index: -0.2800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0218
    Cell Significance Index: -0.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0229
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0230
    Cell Significance Index: -0.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0245
    Cell Significance Index: -0.3100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0263
    Cell Significance Index: -0.3100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0267
    Cell Significance Index: -0.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0282
    Cell Significance Index: -0.3800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0286
    Cell Significance Index: -0.2800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0288
    Cell Significance Index: -0.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0289
    Cell Significance Index: -0.3800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0301
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0303
    Cell Significance Index: -0.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0308
    Cell Significance Index: -0.3900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0310
    Cell Significance Index: -0.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0317
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0323
    Cell Significance Index: -0.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0329
    Cell Significance Index: -0.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0332
    Cell Significance Index: -0.4300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0336
    Cell Significance Index: -0.2900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0337
    Cell Significance Index: -0.2900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0339
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0342
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0357
    Cell Significance Index: -0.4900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0359
    Cell Significance Index: -0.3000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0362
    Cell Significance Index: -0.4200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0362
    Cell Significance Index: -0.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0375
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0385
    Cell Significance Index: -0.4100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0387
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0390
    Cell Significance Index: -0.4400
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0391
    Cell Significance Index: -0.3500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0392
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0392
    Cell Significance Index: -0.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0394
    Cell Significance Index: -0.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0400
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0403
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0404
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0406
    Cell Significance Index: -0.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0411
    Cell Significance Index: -0.3500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0414
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0415
    Cell Significance Index: -0.3900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0415
    Cell Significance Index: -0.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0415
    Cell Significance Index: -0.5900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0416
    Cell Significance Index: -0.4500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0416
    Cell Significance Index: -0.5000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0417
    Cell Significance Index: -0.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0427
    Cell Significance Index: -0.4300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0431
    Cell Significance Index: -0.4600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0433
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0437
    Cell Significance Index: -0.4500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0442
    Cell Significance Index: -0.4900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0445
    Cell Significance Index: -0.4800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0446
    Cell Significance Index: -0.3900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0451
    Cell Significance Index: -0.4500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0454
    Cell Significance Index: -0.4200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0460
    Cell Significance Index: -0.5600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0461
    Cell Significance Index: -0.5100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0473
    Cell Significance Index: -0.4800
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0481
    Cell Significance Index: -0.4700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0484
    Cell Significance Index: -0.4400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0487
    Cell Significance Index: -0.5100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0487
    Cell Significance Index: -0.4400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0493
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0494
    Cell Significance Index: -0.5200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0496
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0500
    Cell Significance Index: -0.4700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0503
    Cell Significance Index: -0.5800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0506
    Cell Significance Index: -0.4600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0533
    Cell Significance Index: -0.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV40 is a single-copy gene, with a relatively small transcript size of approximately 1.3 kb. It is predominantly expressed in hematopoietic cells, including lymphocytes, macrophages, and granulocytes. The gene's expression is tightly regulated, with a high degree of specificity, ensuring that TRAV40 is only expressed in cells that require TCR function. Notably, TRAV40 is also expressed in non-hematopoietic cells, such as goblet cells and intestinal crypt stem cells, suggesting a broader role in tissue homeostasis and immune surveillance. **Pathways and Functions:** TRAV40 is integral to the adaptive immune response, specifically to T cell receptor-mediated signaling. The TCR alpha chain, comprising TRAV40 and TRAV1-9, recognizes and binds to specific peptide-MHC complexes on antigen-presenting cells. Upon binding, the TCR alpha chain undergoes conformational changes, triggering a cascade of signaling events that activate T cells. TRAV40 is essential for this process, as it provides the variable region of the TCR alpha chain that recognizes and binds to antigens. The signaling pathways involving TRAV40 are complex and involve multiple molecules, including TCR zeta chains, CD4 and CD8 co-receptors, and intracellular signaling proteins like ZAP-70 and LCK. These interactions ultimately lead to the activation, proliferation, and differentiation of T cells, which are critical for mounting an effective immune response. **Clinical Significance:** Dysregulation of TRAV40 expression has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For instance, aberrant expression of TRAV40 has been observed in patients with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, suggesting a potential link between TRAV40 dysregulation and disease pathogenesis. Furthermore, TRAV40 has been identified as a tumor suppressor gene in certain types of cancer, such as lymphoma and leukemia. The loss of TRAV40 expression has been correlated with tumor progression and poor prognosis, highlighting the potential of TRAV40 as a therapeutic target. In conclusion, the TRAV40 gene plays a vital role in the adaptive immune response, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the mechanisms underlying TRAV40 expression and its impact on immune function and disease. **Significantly expressed cells:** - Macrophage - Hematopoietic cell - Lymphocyte - Granulocyte monocyte progenitor cell - Goblet cell - Early T lineage precursor - Absorptive cell - Intestinal crypt stem cell of colon - Transit amplifying cell - Abnormal cell

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.