Details for: TRAV40

Gene ID: 28641

Symbol: TRAV40

Ensembl ID: ENSG00000211819

Description: T cell receptor alpha variable 40

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 8.55
    Marker Score: 9,506
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 4.13
    Marker Score: 2,744
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.13
    Marker Score: 1,077
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 877
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 803
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,472
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 482
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 522
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.65
    Marker Score: 393
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.55
    Marker Score: 714
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 482
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 221
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.36
    Marker Score: 712
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.34
    Marker Score: 235
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 482
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.21
    Marker Score: 232
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.19
    Marker Score: 157
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.17
    Marker Score: 131
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.17
    Marker Score: 277
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 161
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.14
    Marker Score: 246
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.13
    Marker Score: 288
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.12
    Marker Score: 127
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 138
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 79
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.06
    Marker Score: 556
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.06
    Marker Score: 170
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.05
    Marker Score: 87
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.04
    Marker Score: 43
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.04
    Marker Score: 53
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.04
    Marker Score: 30
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 34
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.02
    Marker Score: 81
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 719
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 99
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0
    Marker Score: 28
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV40 is a single-copy gene, with a relatively small transcript size of approximately 1.3 kb. It is predominantly expressed in hematopoietic cells, including lymphocytes, macrophages, and granulocytes. The gene's expression is tightly regulated, with a high degree of specificity, ensuring that TRAV40 is only expressed in cells that require TCR function. Notably, TRAV40 is also expressed in non-hematopoietic cells, such as goblet cells and intestinal crypt stem cells, suggesting a broader role in tissue homeostasis and immune surveillance. **Pathways and Functions:** TRAV40 is integral to the adaptive immune response, specifically to T cell receptor-mediated signaling. The TCR alpha chain, comprising TRAV40 and TRAV1-9, recognizes and binds to specific peptide-MHC complexes on antigen-presenting cells. Upon binding, the TCR alpha chain undergoes conformational changes, triggering a cascade of signaling events that activate T cells. TRAV40 is essential for this process, as it provides the variable region of the TCR alpha chain that recognizes and binds to antigens. The signaling pathways involving TRAV40 are complex and involve multiple molecules, including TCR zeta chains, CD4 and CD8 co-receptors, and intracellular signaling proteins like ZAP-70 and LCK. These interactions ultimately lead to the activation, proliferation, and differentiation of T cells, which are critical for mounting an effective immune response. **Clinical Significance:** Dysregulation of TRAV40 expression has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For instance, aberrant expression of TRAV40 has been observed in patients with multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, suggesting a potential link between TRAV40 dysregulation and disease pathogenesis. Furthermore, TRAV40 has been identified as a tumor suppressor gene in certain types of cancer, such as lymphoma and leukemia. The loss of TRAV40 expression has been correlated with tumor progression and poor prognosis, highlighting the potential of TRAV40 as a therapeutic target. In conclusion, the TRAV40 gene plays a vital role in the adaptive immune response, and its dysregulation has significant clinical implications. Further research is needed to fully elucidate the mechanisms underlying TRAV40 expression and its impact on immune function and disease. **Significantly expressed cells:** - Macrophage - Hematopoietic cell - Lymphocyte - Granulocyte monocyte progenitor cell - Goblet cell - Early T lineage precursor - Absorptive cell - Intestinal crypt stem cell of colon - Transit amplifying cell - Abnormal cell

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.