Details for: TRAV27

Gene ID: 28655

Symbol: TRAV27

Ensembl ID: ENSG00000211809

Description: T cell receptor alpha variable 27

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10,802
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.48
    Marker Score: 983
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,567
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,648
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,718
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,317
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.77
    Marker Score: 444
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.42
    Marker Score: 372
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.41
    Marker Score: 364
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.38
    Marker Score: 323
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 214
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.3
    Marker Score: 514
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.29
    Marker Score: 888
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.25
    Marker Score: 114
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.24
    Marker Score: 203
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.21
    Marker Score: 166
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.18
    Marker Score: 198
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.18
    Marker Score: 325
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.17
    Marker Score: 135
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.15
    Marker Score: 160
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.14
    Marker Score: 274
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.14
    Marker Score: 586
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.12
    Marker Score: 295
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.12
    Marker Score: 6,138
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.11
    Marker Score: 79
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.09
    Marker Score: 124
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.08
    Marker Score: 964
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.07
    Marker Score: 203
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 87
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.06
    Marker Score: 142
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.06
    Marker Score: 102
  • Cell Name: T-helper 2 cell (CL0000546)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.06
    Marker Score: 574
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 64
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 77
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.04
    Marker Score: 57
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 161
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.03
    Marker Score: 84
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 30
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 21

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAV27 is a member of the TRAV gene family, which consists of 29 genes that encode for the variable regions of the T cell receptor alpha chain. The TRAV27 gene is characterized by its ability to generate diversity in the T cell receptor, allowing for the recognition of a wide range of antigens. The gene is also notable for its expression in various cell types, including goblet cells, hematopoietic cells, and granulocytes, which suggests its role in immune responses and tissue homeostasis. **Pathways and Functions** The TRAV27 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: TRAV27 is essential for the development of alpha-beta T cells, which play a central role in cell-mediated immunity against pathogens. 2. **Alpha-Beta T Cell Receptor Complex**: TRAV27 is part of the T cell receptor complex, which recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules. 3. **Defense Response to Gram-Positive Bacterium**: TRAV27 is involved in the recognition and elimination of gram-positive bacteria, which are a common cause of infections in humans. 4. **Immune Response**: TRAV27 is part of the immune response, which involves the activation of immune cells, such as T cells and B cells, to recognize and eliminate pathogens. 5. **Protein Binding**: TRAV27 is involved in protein binding, which is essential for the maturation and function of T cell receptors. **Clinical Significance** The TRAV27 gene has significant clinical implications, particularly in the context of immune-mediated diseases. Abnormalities in TRAV27 expression have been associated with various diseases, including: 1. **Autoimmune Disorders**: TRAV27 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where the immune system attacks the body's own tissues. 2. **Infectious Diseases**: TRAV27 is involved in the defense against gram-positive bacteria, and abnormalities in TRAV27 expression may contribute to the development of bacterial infections. 3. **Cancer**: TRAV27 has been identified in various types of cancer, including leukemia and lymphoma, where it may play a role in tumor development and progression. In conclusion, the TRAV27 gene is a critical component of the adaptive immune system, and its dysregulation has significant clinical implications. Further research is needed to fully understand the role of TRAV27 in immune responses and disease, and to develop effective therapeutic strategies to modulate its expression and function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.