Details for: TRAV27

Gene ID: 28655

Symbol: TRAV27

Ensembl ID: ENSG00000211809

Description: T cell receptor alpha variable 27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.8423
    Cell Significance Index: 25.7000
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0617
    Cell Significance Index: 0.7400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0376
    Cell Significance Index: 0.4200
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0395
    Cell Significance Index: -0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0631
    Cell Significance Index: -3.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0662
    Cell Significance Index: -3.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0776
    Cell Significance Index: -1.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0802
    Cell Significance Index: -1.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1275
    Cell Significance Index: -3.4100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1397
    Cell Significance Index: -1.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1411
    Cell Significance Index: -3.5200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1430
    Cell Significance Index: -0.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1431
    Cell Significance Index: -2.4100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1454
    Cell Significance Index: -1.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1501
    Cell Significance Index: -3.7500
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1511
    Cell Significance Index: -1.4800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1556
    Cell Significance Index: -1.6400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1688
    Cell Significance Index: -2.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1721
    Cell Significance Index: -2.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1727
    Cell Significance Index: -4.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1732
    Cell Significance Index: -2.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1849
    Cell Significance Index: -3.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1854
    Cell Significance Index: -5.0500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1855
    Cell Significance Index: -1.8600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1973
    Cell Significance Index: -1.4200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2148
    Cell Significance Index: -2.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2169
    Cell Significance Index: -4.2400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2177
    Cell Significance Index: -3.5000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2385
    Cell Significance Index: -4.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2386
    Cell Significance Index: -4.4100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2425
    Cell Significance Index: -3.3300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2498
    Cell Significance Index: -1.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2559
    Cell Significance Index: -3.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2574
    Cell Significance Index: -3.9100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2594
    Cell Significance Index: -2.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2623
    Cell Significance Index: -2.7200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2624
    Cell Significance Index: -2.4000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2670
    Cell Significance Index: -3.4300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2672
    Cell Significance Index: -3.3100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2779
    Cell Significance Index: -2.3900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2786
    Cell Significance Index: -3.9100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2801
    Cell Significance Index: -3.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2804
    Cell Significance Index: -3.3100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2829
    Cell Significance Index: -3.8800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2829
    Cell Significance Index: -3.6600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2865
    Cell Significance Index: -2.7500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2894
    Cell Significance Index: -3.4200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2897
    Cell Significance Index: -3.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2941
    Cell Significance Index: -3.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2972
    Cell Significance Index: -3.9000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2983
    Cell Significance Index: -3.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2984
    Cell Significance Index: -4.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3014
    Cell Significance Index: -2.8300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3059
    Cell Significance Index: -3.0900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3093
    Cell Significance Index: -4.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3100
    Cell Significance Index: -3.9800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3114
    Cell Significance Index: -3.1600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3133
    Cell Significance Index: -2.4700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3171
    Cell Significance Index: -3.2000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3173
    Cell Significance Index: -5.4700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3180
    Cell Significance Index: -3.4600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.3184
    Cell Significance Index: -2.1900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3242
    Cell Significance Index: -3.1600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3245
    Cell Significance Index: -2.8000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3258
    Cell Significance Index: -3.9600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3273
    Cell Significance Index: -3.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3287
    Cell Significance Index: -4.0400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3291
    Cell Significance Index: -3.1200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3370
    Cell Significance Index: -4.0100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.3383
    Cell Significance Index: -3.5000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3424
    Cell Significance Index: -3.5500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3432
    Cell Significance Index: -4.0800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3445
    Cell Significance Index: -4.0500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3454
    Cell Significance Index: -4.1000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3493
    Cell Significance Index: -4.0200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3501
    Cell Significance Index: -4.5700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3501
    Cell Significance Index: -3.2800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3502
    Cell Significance Index: -4.0300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3539
    Cell Significance Index: -4.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3543
    Cell Significance Index: -4.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3569
    Cell Significance Index: -3.4300
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.3585
    Cell Significance Index: -3.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3590
    Cell Significance Index: -5.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3593
    Cell Significance Index: -3.9800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3593
    Cell Significance Index: -3.9200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.3627
    Cell Significance Index: -3.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3636
    Cell Significance Index: -3.9200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3649
    Cell Significance Index: -3.0500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3693
    Cell Significance Index: -4.0400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3707
    Cell Significance Index: -4.5100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3715
    Cell Significance Index: -4.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3723
    Cell Significance Index: -4.4000
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.3746
    Cell Significance Index: -3.5100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3786
    Cell Significance Index: -3.8700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.3804
    Cell Significance Index: -3.0800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3807
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3813
    Cell Significance Index: -4.2400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3833
    Cell Significance Index: -3.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3887
    Cell Significance Index: -4.1000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3908
    Cell Significance Index: -3.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAV27 is a member of the TRAV gene family, which consists of 29 genes that encode for the variable regions of the T cell receptor alpha chain. The TRAV27 gene is characterized by its ability to generate diversity in the T cell receptor, allowing for the recognition of a wide range of antigens. The gene is also notable for its expression in various cell types, including goblet cells, hematopoietic cells, and granulocytes, which suggests its role in immune responses and tissue homeostasis. **Pathways and Functions** The TRAV27 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: TRAV27 is essential for the development of alpha-beta T cells, which play a central role in cell-mediated immunity against pathogens. 2. **Alpha-Beta T Cell Receptor Complex**: TRAV27 is part of the T cell receptor complex, which recognizes and binds to antigens presented by major histocompatibility complex (MHC) molecules. 3. **Defense Response to Gram-Positive Bacterium**: TRAV27 is involved in the recognition and elimination of gram-positive bacteria, which are a common cause of infections in humans. 4. **Immune Response**: TRAV27 is part of the immune response, which involves the activation of immune cells, such as T cells and B cells, to recognize and eliminate pathogens. 5. **Protein Binding**: TRAV27 is involved in protein binding, which is essential for the maturation and function of T cell receptors. **Clinical Significance** The TRAV27 gene has significant clinical implications, particularly in the context of immune-mediated diseases. Abnormalities in TRAV27 expression have been associated with various diseases, including: 1. **Autoimmune Disorders**: TRAV27 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, where the immune system attacks the body's own tissues. 2. **Infectious Diseases**: TRAV27 is involved in the defense against gram-positive bacteria, and abnormalities in TRAV27 expression may contribute to the development of bacterial infections. 3. **Cancer**: TRAV27 has been identified in various types of cancer, including leukemia and lymphoma, where it may play a role in tumor development and progression. In conclusion, the TRAV27 gene is a critical component of the adaptive immune system, and its dysregulation has significant clinical implications. Further research is needed to fully understand the role of TRAV27 in immune responses and disease, and to develop effective therapeutic strategies to modulate its expression and function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.